Frequency-Rank Correlations of Rhodopsin Mutations with Tuned Hydropathic Roughness Based on Self-Organized Criticality

The behavior of disease-linked mutations of membrane proteins is especially simple in rhodopsin, where they are well-studied, as they are responsible for retinitis pigmentosa, RP (retinal degeneration). Here we show that the frequency of occurrence of single RP mutations is strongly influenced by their posttranslational survival rates, and that this survival correlates well (82%) with a long-range, non-local hydropathic measure of the roughness of the water interfaces of ex-membrane rhodopsin based on self-organized criticality (SOC). It is speculated that this concept may be generally useful in studying survival rates of many mutated proteins

Polarized inclusive leptoproduction, ℓN→hX\ell N \to hX, and the hadron helicity density matrix, ρ(h)\rho(h): possible measurements and predictions

We discuss the production of hadrons in polarized lepton nucleon interactions and in the current jet fragmentation region; using the QCD hard scattering formalism we compute the helicity density matrix of the hadron and show how its elements, when measurable, can give information on the spin structure of the nucleon and the spin dependence of the quark fragmentation process. The cases of $\rho$ vector mesons and $\Lambda$ baryons are considered in more details and, within simplifying assumptions, some estimates are given.Comment: 17 pages + 4 figures, plain LATeX, figures appended as uuencoded, compressed postscript fil

Ethyl 2-[(carbamothioyl­amino)­imino]­propano­ate

The title compound, C6H11N3O2S, consists of a roughly planar mol­ecule (r.m.s deviation from planarity = 0.077 Å for the non-H atoms) and has the S atom in an anti position to the imine N atom. This N atom is the acceptor of a strongly bent inter­nal N—H⋯N hydrogen bond donated by the amino group. In the crystal, mol­ecules are arranged in undulating layers parallel to (010). The mol­ecules are linked via inter­molecular amino–carboxyl N—H⋯O hydrogen bonds, forming chains parallel to [001]. The chains are cross-linked by Ncarbazone—H⋯S and C—H⋯S inter­actions, forming infinite sheets

Mixed metal node effect in zeolitic imidazolate frameworks

We synthesized two series of bimetallic (zinc and cobalt) zeolitic imidazolate frameworks (ZIF-62) under different solvothermal conditions. It is found that the structure of the derived ZIF crystals is highly sensitive to synthesis conditions. One series possesses the standard ZIF-62 structure, whereas the other has a mixed structure composed of both the standard structure and an unknown one. The standard series exhibits a slight negative deviation from linearity of melting temperature (T(m)) and glass transition temperature (T(g)) with the substitution of Co for Zn. In contrast, the new series displays a stronger negative deviation. These negative deviations from linearity indicate the mixed metal node effect in bimetallic ZIF-62 due to the structural mismatch between Co(2+) and Zn(2+) and to the difference in their electronic configurations. The new series involves both cobalt-rich and zinc-rich phases, whereas the standard one shows one homogeneous phase. Density functional theory calculations predict that the substitution of Co for Zn increases the bulk modulus of the ZIF crystals. This work indicates that the structure, melting behaviour, and mechanical properties of ZIFs can be tuned by metal node substitution and by varying the synthetic conditions. Both series of ZIFs have higher glass forming abilities due to their higher T(g)/T(m) ratios (0.77–0.84) compared to most good glass formers

Single spin asymmetries in QCD

Measurements of single transverse spin asymmetries in high energy inclusive processes have always shown unexpected and challenging results. Several cases are considered and discussed within a QCD approach which couples perturbative dynamics to new non perturbative partonic information; the aim is that of developing a consistent phenomenological description of these unusual single spin phenomena, based on a generalized QCD factorization scheme.Comment: 14 pages, lectures delivered at School on "Symmetries and Spin", Praha-SPIN-2001, Prague, July 15 - July 28, 200