53 research outputs found

    A multi-disciplinary perspective on climate model evaluation for Antarctica

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    A workshop was organized by Antarctic Climate 21 (AntClim21), with the topic 'evaluation of climate models' representation of Antarctic climate from the perspective of long-term twenty-first-century climate change.' The suggested approach for evaluating whether climate models over- or underestimate the effects of ozone depletion is to diagnose simulated historical trends in lower-stratospheric temperature and compare these to observational estimates. With regard to more regional changes over Antarctica, such as West Antarctic warming, the simulation of teleconnection patterns to the tropical Pacific was highlighted. To improve the evaluation of low-frequency variability and trends in climate models, the use and development of approaches to emulate ice-core proxies in models was recommended. It is recommended that effort be put into improving datasets of ice thickness, motion, and composition to allow for a more complete evaluation of sea ice in climate models. One process that was highlighted in particular is the representation of Antarctic clouds and resulting precipitation. It is recommended that increased effort be put into observations of clouds over Antarctica, such as the use of instruments that can detect cloud-base height or the use of remote sensing resources

    Back to the future : using long-term observational and paleo-proxy reconstructions to improve model projections of Antarctic climate

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    Quantitative estimates of future Antarctic climate change are derived from numerical global climate models. Evaluation of the reliability of climate model projections involves many lines of evidence on past performance combined with knowledge of the processes that need to be represented. Routine model evaluation is mainly based on the modern observational period, which started with the establishment of a network of Antarctic weather stations in 1957/58. This period is too short to evaluate many fundamental aspects of the Antarctic and Southern Ocean climate system, such as decadal-to-century time-scale climate variability and trends. To help address this gap, we present a new evaluation of potential ways in which long-term observational and paleo-proxy reconstructions may be used, with a particular focus on improving projections. A wide range of data sources and time periods is included, ranging from ship observations of the early 20th century to ice core records spanning hundreds to hundreds of thousands of years to sediment records dating back 34 million years. We conclude that paleo-proxy records and long-term observational datasets are an underused resource in terms of strategies for improving Antarctic climate projections for the 21st century and beyond. We identify priorities and suggest next steps to addressing this

    Human influence on extratropical Southern Hemisphere precipitation

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    Observations of extratropical Southern Hemisphere austral summer precipitation over recent decades show mid-latitude drying and high-latitude moistening. Here we show that the observed precipitation trends in two datasets are inconsistent with simulated internal variability, but are closely consistent with trends simulated in response to historical changes in anthropogenic and natural forcings. Simulations with individual anthropogenic and natural forcings suggest that the observed pattern of precipitation change is substantially forced by anthropogenic greenhouse gas and ozone changes, with an opposing influence from aerosols. Our results demonstrate that human influence had a significant impact on precipitation across the mid and high latitudes of the Southern Hemisphere, changes which are expected to have a profound impact on Southern Ocean stratification and hence on ocean-atmosphere heat and carbon fluxes

    Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D-3

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    Steroid hormones are central regulators of a variety of biological processes. According to the free hormone hypothesis, steroids enter target cells by passive diffusion. However, recently we demonstrated that 25(OH) vitamin D3 complexed to its plasma carrier, the vitamin D-binding protein, enters renal proximal tubules by receptor-mediated endocytosis. Knockout mice lacking the endocytic receptor megalin lose 25(OH) vitamin D3 in the urine and develop bone disease. Here, we report that cubilin, a membrane-associated protein colocalizing with megalin, facilitates the endocytic process by sequestering steroid-carrier complexes on the cellular surface before megalin-mediated internalization of the cubilin-bound ligand. Dogs with an inherited disorder affecting cubilin biosynthesis exhibit abnormal vitamin D metabolism. Similarly, human patients with mutations causing cubilin dysfunction exhibit urinary excretion of 25(OH) vitamin D3. This observation identifies spontaneous mutations in an endocytic receptor pathway affecting cellular uptake and metabolism of a steroid hormone
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