36 research outputs found
New insights into the genetic etiology of Alzheimer's disease and related dementias.
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele
New insights into the genetic etiology of Alzheimer's disease and related dementias
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele
Conversion chimique des revĂȘtements zinguĂ©s. caractĂ©risation des substrats traitĂ©s et mesure dâadhĂ©rence de systĂšmes peints
La phosphatation de revĂȘtements zinguĂ©s est Ă©tudiĂ©e Ă lâaide de techniques Ă©lectrochimique (mesure du potentiel dâabandon) et Ă©lectrique (impĂ©dancemĂ©trie) permettant de suivre la formation de la couche in situ, et par des techniques de caractĂ©risation de surface (MEB, SDL, LEEIXS) et de mesure dâadhĂ©rence (flexion trois points) avant ou aprĂšs traitement. Lâutilisation de ces techniques, (qui sont complĂ©mentaires) nous a permis de mettre en Ă©vidence lâinfluence des prĂ©traitements (dĂ©graissages, affinage) et de lâaddition de fluorures (dans le bain phosphatant) sur la phosphatation
Influence of metallurgical parameters on hydrogen induced cracking in line pipe steels
17.50; Translated from French (Cah. Inf. Tech./Rev. Metall. 1986 v. 83(12) p. 891-899)Available from British Library Document Supply Centre- DSC:9022.06(BISI-Trans--26682)T / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo