Geostatistical and multi-elemental analysis of soils to interpret land-use history in the Hebrides, Scotland

In the absence of documentary evidence about settlement form and agricultural practice in northwest Scotland before the mid-18th century, a geoarchaeological approach to reconstructing medieval land use and settlement form is presented here. This study applies multielemental analysis to soils previously collected from a settlement site in the Hebrides and highlights the importance of a detailed knowledge of the local soil environment and the cultural context. Geostatistical methods were used to analyze the spatial variability and distribution of a range of soil properties typically associated with geoarchaeological investigations. Semivariograms were produced to determine the spatial dependence of soil properties, and ordinary kriging was undertaken to produce prediction maps of the spatial distribution of these soil properties and enable interpolation over nonsampled locations in an attempt to more fully elucidate former land-use activity and settlement patterns. The importance of identifying the spatial covariance of elements and the need for several lines of physical and chemical evidence is highlighted. For many townships in the Hebrides, whose precise location and layout prior to extensive land reorganization in the late 18th–early 19th century is not recoverable through plans, multi-elemental analysis of soils can offer a valuable prospective and diagnostic tool

Faults and fractures in central West Greenland: onshore expression of continental break-up and sea-floor spreading in the Labrador – Baffin Bay Sea

The complex Ungava fault zone lies in the Davis Strait and separates failed spreading centres in the Labrador Sea and Baffin Bay. This study focuses on coastal exposures east of the fault-bound Sisimiut basin, where the onshore expressions of these fault systems and the influence of pre-existing basement are examined. Regional lineament studies identify five main systems: N–S, NNE–SSW, ENE–WSW, ESE–WNW and NNW–SSE. Field studies reveal that strike-slip movements predominate, and are consistent with a ~NNE–SSW-oriented sinistral wrench system. Extensional faults trending N–S and ENE–WSW (basement-parallel), and compressional faults trending E–W, were also identified. The relative ages of these fault systems have been interpreted using cross-cutting relationships and by correlation with previously identified structures. A two-phase model for fault development fits the development of both the onshore fault systems observed in this study and regional tectonic structures offshore. The conclusions from this study show that the fault patterns and sense of movement on faults onshore reflect the stress fields that govern the opening of the Labrador Sea – Davis Strait – Baffin Bay seaway, and that the wrench couple on the Ungava transform system played a dominant role in the development of the onshore fault patterns

Functional expression of chemokine receptor CXCR4 on human epithelial cells

Chemokines and their receptors play an important role in the process of leucocyte recruitment at sites of inflammation. However, recent evidence suggests that these proteins can also regulate non-leucocyte cell functions such as angiogenesis, migration and proliferation. We have investigated the expression of the CXC chemokine receptor 4 (CXCR4) on primary cultures of type II alveolar epithelial cells, their transformed counterpart, the A549 cell line and also on other epithelial cell lines from various tissues. We found that all epithelial cell types tested express mRNA for CXCR4. Flow cytometric analysis and immunocytochemical staining shows that CXCR4 chemokine receptor is abundantly expressed on the surface of A549 epithelial cells. Furthermore, A549 cells responded to the CXCR4 ligand, stromal-derived factor-1α (SDF-1α) with a rapid and robust calcium mobilization and not to other CXC chemokines, suggesting that CXCR4 is functionally active and is able to couple to G-protein signalling mechanisms. A549 cells did not proliferate in response to either SDF-1α or interleukin-8 (IL-8) CXC chemokines. These findings may have important implications for epithelial physiology and pathology