29 research outputs found
Contrast-Enhanced MR Imaging of Brain Lesions: A Large-Scale Intraindividual Crossover Comparison of Gadobenate Dimeglumine versus Gadodiamide
Adição de óleo de palma na dieta sobre a lipidemia e a qualidade do sêmen de bubalinos (Bubalus bubalis)
Combining Graph and Machine Learning Methods to Analyze Differences in Functional Connectivity Across Sex
Anoxic Injury-Associated Cerebral Hyperperfusion Identified with Arterial Spin-Labeled MR Imaging
Identification of Functional Clusters in the Striatum Using Infinite Relational Modeling
Microstructural correlates of 3D steady-state inhomogeneous magnetization transfer (ihMT) in the human brain white matter assessed by myelin water imaging and diffusion tensor imaging
Purpose: To compare the recently introduced inhomogeneous magnetization transfer ihMT) technique with more established MRI techniques including myelin water imaging (MWI) and diffusion tensor imaging (DTI), and to evaluate the microstructural attributes correlating with this new contrast method in the human brain white matter.Methods: Eight adult healthy volunteers underwent T-1-weighted, ihMT, MWI, and DTI imaging on a 3T human scanner. The ihMT ratio (ihMTR), myelin water fraction (MWF), fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity (AD), and mean diffusivity (MD) values were calculated from different white matter tracts. The angle (theta) between the directions of the principal eigenvector, as measured by DTI, and the main magnetic field was calculated for all voxels from various fiber tracts. The ihMTR was correlated with MWF and DTI metrics.Results: A strong correlation was found between ihMTR and MWF (rho = 0.77, P < 0.0001). This was followed by moderate to weak correlations between ihMTR and DTI metrics: RD (rho = 20.30, P < 0.0001), FA (rho = 0.20, P < 0.0001), MD (rho = 20.19, P < 0.0001), AD (rho = 0.02, P < 0.0001). A strong correlation was found between ihMTR and u (rho = 20.541, P < 0.0001).Conclusion: The strong correlation with myelin water imaging and its low coefficient of variation suggest that ihMT has the potential to become a new structural imaging marker of myelin. The substantial orientational dependence of ihMT should be taken into account when evaluating and quantitatively interpreting ihMT results.Neuro Imaging Researc