Particulate matter and episodic memory decline mediated by early neuroanatomic biomarkers of Alzheimer's disease

Evidence suggests exposure to particulate matter with aerodynamic diameter <2.5 μm (PM2.5) may increase the risk for Alzheimer's disease and related dementias. Whether PM2.5 alters brain structure and accelerates the preclinical neuropsychological processes remains unknown. Early decline of episodic memory is detectable in preclinical Alzheimer's disease. Therefore, we conducted a longitudinal study to examine whether PM2.5 affects the episodic memory decline, and also explored the potential mediating role of increased neuroanatomic risk of Alzheimer's disease associated with exposure. Participants included older females (n = 998; aged 73-87) enrolled in both the Women's Health Initiative Study of Cognitive Aging and the Women's Health Initiative Memory Study of Magnetic Resonance Imaging, with annual (1999-2010) episodic memory assessment by the California Verbal Learning Test, including measures of immediate free recall/new learning (List A Trials 1-3; List B) and delayed free recall (shortand long-delay), and up to two brain scans (MRI-1: 2005-06; MRI-2: 2009-10). Subjects were assigned Alzheimer's disease pattern similarity scores (a brain-MRI measured neuroanatomical risk for Alzheimer's disease), developed by supervised machine learning and validated with data from the Alzheimer's Disease Neuroimaging Initiative. Based on residential histories and environmental data on air monitoring and simulated atmospheric chemistry, we used a spatiotemporal model to estimate 3-year average PM2.5 exposure preceding MRI-1. In multilevel structural equation models, PM2.5 was associated with greater declines in immediate recall and new learning, but no association was found with decline in delayed-recall or composite scores. For each interquartile increment (2.81 μg/m3) of PM2.5, the annual decline rate was significantly accelerated by 19.3% [95% confidence interval (CI) = 1.9% to 36.2%] for Trials 1-3 and 14.8% (4.4% to 24.9%) for List B performance, adjusting for multiple potential confounders. Long-term PM2.5 exposure was associated with increased Alzheimer's disease pattern similarity scores, which accounted for 22.6% (95% CI: 1% to 68.9%) and 10.7% (95% CI: 1.0% to 30.3%) of the total adverse PM2.5 effects on Trials 1-3 and List B, respectively. The observed associations remained after excluding incident cases of dementia and stroke during the follow-up, or further adjusting for small-vessel ischaemic disease volumes. Our findings illustrate the continuum of PM2.5 neurotoxicity that contributes to early decline of immediate free recall/new learning at the preclinical stage, which is mediated by progressive atrophy of grey matter indicative of increased Alzheimer's disease risk, independent of cerebrovascular damage

Stress corrosion cracking of zirconium in nitric acid

The susceptibility of zirconium and its common alloys to stress corrosion cracking (SCC) in nitric acid was investigated by slow strain-rate and constant deflection techniques. Cracking occurred at 25/sup 0/C over a wide range of acid concentrations and electrochemical potentials. The crack velocity increased slightly with increasing temperature. The failure mode was transgranular and the morphology was similar to SCC failures of zirconium alloys in other environments. The fracture was very orientation-dependent suggesting that it occurs on a single crystallographic plane in the material. The results of the study are not consistent with a hydrogen mechanism for cracking

Abundance and distribution of the endangered loggerhead turtle in Spanish Mediterranean waters and the conservation implications

During 2 years (2001–2003), we performed seasonal aerial surveys in the central Spanish Mediterranean following the transect line methodology in order to determine the abundance and distribution patterns of loggerhead turtles Caretta caretta. We surveyed a total of 16 700 km, accounting for 770 turtle sightings. Loggerhead turtles were present with high abundance all year round. No seasonal differences in abundance were found, except in spring 2001, where the density of turtles was higher than in the other seasons. Our results show that the Western Mediterranean is not a ‘summer’ feeding area as proposed previously, as a high number of turtles are present throughout the year. The average surface density of turtles in the whole study area was 0.21 turtles km 2 [95% confidence interval (CI): 0.17–0.25], and the mean abundance was 6653 turtles (95% CI: 5514–8027). The data relate to the number of turtles on the surface only, as diving turtles escape observation. Correcting our estimations of diving behaviour data in the area, the absolute abundance was 18 954 turtles (95% CI: 6679–53 786). Bearing in mind that around 25 000 loggerheads are caught per year in the Spanish Mediterranean, our results indicate that accidental captures seem to be a significant threat for this species, and conservation measures have to be implemented to avoid a non- sustainable situation.Fil: Gómez de Segura, A.. Cavanilles Institute of Biodiversity and Evolutionary Biology. Marine Zoology Unit; EspañaFil: Tomás, J.. Cavanilles Institute of Biodiversity and Evolutionary Biology. Marine Zoology Unit; España. L’Oceanográfic; EspañaFil: Pedraza, Susana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; ArgentinaFil: Crespo, Enrique Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; ArgentinaFil: Raga, Juan Antonio. Cavanilles Institute of Biodiversity and Evolutionary Biology. Marine Zoology Unit; Españ