Ergodicity of certain cocycles over certain interval exchanges

We show that for odd-valued piecewise-constant skew products over a certain two parameter family of interval exchanges, the skew product is ergodic for a full-measure choice of parameters

Организация и ведение поисково и аварийно-спасательных работ на водоемах

Проведение поисковых и аварийно-спасательных работ на воде с применением спасательных судов при возникновении чрезвычайных ситуаций является одной из основных задач Единой государственной системы предупреждения и ликвидации чрезвычайных ситуаций (РСЧС), позволяющих уменьшить жертвы и сохранить здоровье людей. Спасение терпящих бедствие на воде должно быть организовано своевременно, оперативно и комплексно, то есть в полном объеме по всём необходимым в конкретной обстановке видам работ по спасению пострадавших.Conducting search and rescue operations on the water with the use of rescue vessels in the event of emergencies is one of the main tasks of the Unified State System for the Prevention and Elimination of Emergencies (RSES), which makes it possible to reduce casualties and preserve people's health. Salvation of those in distress on the water must be organized in a timely manner, promptly and in a comprehensive manner, that is, in full volume for all kinds of rescue work for the victims

Ergodic infinite group extensions of geodesic flows on translation surfaces

We show that generic infinite group extensions of geodesic flows on square tiled translation surfaces are ergodic in almost every direction, subject to certain natural constraints. Recently K. Fr\c{a}czek and C. Ulcigrai have shown that certain concrete staircases, covers of square-tiled surfaces, are not ergodic in almost every direction. In contrast we show the almost sure ergodicity of other concrete staircases. An appendix provides a combinatorial approach for the study of square-tiled surfaces

Geometry, topology and dynamics of geodesic flows on noncompact polygonal surfaces

We establish the background for the study of geodesics on noncompact polygonal surfaces. For illustration, we study the recurrence of geodesics on $Z$-periodic polygonal surfaces. We prove, in particular, that almost all geodesics on a topologically typical $Z$-periodic surface with boundary are recurrent.Comment: 34 pages, 13 figures. To be published in V. V. Kozlov's Festschrif

Non-stationary compositions of Anosov diffeomorphisms

Motivated by non-equilibrium phenomena in nature, we study dynamical systems whose time-evolution is determined by non-stationary compositions of chaotic maps. The constituent maps are topologically transitive Anosov diffeomorphisms on a 2-dimensional compact Riemannian manifold, which are allowed to change with time - slowly, but in a rather arbitrary fashion. In particular, such systems admit no invariant measure. By constructing a coupling, we prove that any two sufficiently regular distributions of the initial state converge exponentially with time. Thus, a system of the kind loses memory of its statistical history rapidly

Effects of mesenchymal stromal cells versus serum on tendon healing in a controlled experimental trial in an equine model

Abstract Background Mesenchymal stromal cells (MSC) have shown promising results in the treatment of tendinopathy in equine medicine, making this therapeutic approach seem favorable for translation to human medicine. Having demonstrated that MSC engraft within the tendon lesions after local injection in an equine model, we hypothesized that they would improve tendon healing superior to serum injection alone. Methods Quadrilateral tendon lesions were induced in six horses by mechanical tissue disruption combined with collagenase application 3 weeks before treatment. Adipose-derived MSC suspended in serum or serum alone were then injected intralesionally. Clinical examinations, ultrasound and magnetic resonance imaging were performed over 24 weeks. Tendon biopsies for histological assessment were taken from the hindlimbs 3 weeks after treatment. Horses were sacrificed after 24 weeks and forelimb tendons were subjected to macroscopic and histological examination as well as analysis of musculoskeletal marker expression. Results Tendons injected with MSC showed a transient increase in inflammation and lesion size, as indicated by clinical and imaging parameters between week 3 and 6 (p < 0.05). Thereafter, symptoms decreased in both groups and, except that in MSC-treated tendons, mean lesion signal intensity as seen in T2w magnetic resonance imaging and cellularity as seen in the histology (p < 0.05) were lower, no major differences could be found at week 24. Conclusions These data suggest that MSC have influenced the inflammatory reaction in a way not described in tendinopathy studies before. However, at the endpoint of the current study, 24 weeks after treatment, no distinct improvement was observed in MSC-treated tendons compared to the serum-injected controls. Future studies are necessary to elucidate whether and under which conditions MSC are beneficial for tendon healing before translation into human medicine

Across the tree of life, radiation resistance is governed by antioxidant Mn2+, gauged by paramagnetic resonance

Despite concerted functional genomic efforts to understand the complex phenotype of ionizing radiation (IR) resistance, a genome sequence cannot predict whether a cell is IR-resistant or not. Instead, we report that absorption-display electron paramagnetic resonance (EPR) spectroscopy of nonirradiated cells is highly diagnostic of IR survival and repair efficiency of DNA double-strand breaks (DSBs) caused by exposure to gamma radiation across archaea, bacteria, and eukaryotes, including fungi and human cells. IR-resistant cells, which are efficient at DSB repair, contain a high cellular content of manganous ions (Mn2+) in high-symmetry (H) antioxidant complexes with small metabolites (e.g., orthophosphate, peptides), which exhibit narrow EPR signals (small zero-field splitting). In contrast, Mn2+ ions in IR-sensitive cells, which are inefficient at DSB repair, exist largely as low-symmetry (L) complexes with substantially broadened spectra seen with enzymes and strongly chelating ligands. The fraction of cellular Mn2+ present as H-complexes (H-Mn2+), as measured by EPR of live, nonirradiated Mn-replete cells, is now the strongest known gauge of biological IR resistance between and within organisms representing all three domains of life: Antioxidant H-Mn2+ complexes, not antioxidant enzymes (e.g., Mn superoxide dismutase), govern IR survival. As the pool of intracellular metabolites needed to form H-Mn2+ complexes depends on the nutritional status of the cell, we conclude that IR resistance is predominantly a metabolic phenomenon. In a cross-kingdom analysis, the vast differences in taxonomic classification, genome size, and radioresistance between cell types studied here support that IR resistance is not controlled by the repertoire of DNA repair and antioxidant enzymes

Non-Canonical NF-κB Activation and Abnormal B Cell Accumulation in Mice Expressing Ubiquitin Protein Ligase-Inactive c-IAP2

Loss of c-IAP2 ubiquitin ligase activity, which occurs in the lymphoma-causing c-IAP2/MALT1 fusion protein, activates non-canonical NF-κB signaling and results in B cell abnormalities characteristic of MALT lymphoma