Inhibition of Connexin43 hemichannels impairs spatial short-term memory without affecting spatial working memory

Astrocytes are active players in higher brain function as they can release gliotransmitters, which are essential for synaptic plasticity. Various mechanisms have been proposed for gliotransmission, including vesicular mechanisms as well as non-vesicular ones, for example by passive diffusion via connexin hemichannels (HCs). We here investigated whether interfering with connexin43 (Cx43) HCs influenced hippocampal spatial memory. We made use of the peptide Gap19 that blocks HCs but not gap junction channels and is specific for Cx43. To this end, we microinfused transactivator of transcription linked Gap19 (TAT-Gap19) into the brain ventricle of male NMRI mice and assessed spatial memory in a Y maze. We found that the in vivo blockade of Cx43 HCs did not affect the locomotor activity or spatial working memory in a spontaneous alternation Y maze task. Cx43 blockade did however significantly impair the spatial short-term memory in a delayed spontaneous alternation Y maze task. These results indicate that Cx43 HCs play a role in spatial short-term memory

Replicating Lean Six Sigma Green Belt Education

Purpose – This paper describes the intricates and possibilities of replicating a Lean Six Sigma Green Belt (LSSGB) education model from a pilot program to other universities—employing ‘replication as strategy’—based on a validated ‘business model.’ Study design/methodology/approach – This work is grounded in a case study on the ESTIEM LSSGB educational method and draws on the replication literature. Specifically: (1) replication as strategy (Winter and Szulanski, 2001) to replicate stimulating learning environments, and (2) replicating sets of teaching practices (Baden-Fuller and Winter, 2007). These theories are practiced using data obtained from various sources: Participant-observer data, interview data, and secondary case data. Findings – To replicate this educational program, a thorough understanding of the ‘business model’ of the LSSGB course is required. This includes a clear understanding of what is valued in each local environment, what configurations of practices create such value, and what environments contain the inputs that stimulate such value creation. Moreover, the replicating speed is substantially affected by the replicators’ knowledge on recognizing course locations for replication and successfully implementing a new course with a suitable configuration. In conclusion, replication of teaching practices between courses is mediated by predefined high-quality course content. Originality/value – The LSSGB course in ESTIEM shows how blended learning opportunities can be configured to deliver impact on a European scale. Decomposing a course to teaching practices and analyzing their inputs identifies the environmental requirements for a course. Keywords Lean Six Sigma, blended learning, replication, replication as strategy, ESTIEM Paper type Research pape

Intention to Hack? Applying the Theory of Planned Behaviour to Youth Criminal Hacking

Adolescents are currently the most digitally connected generation in history. There is an ever-growing need to understand how typical adolescent risk-taking intersects with the vastly criminogenic potential of digital technology. Criminal hacking in older adolescents (16–19-year-olds) was assessed using an adapted Theory of Planned Behaviour (TPB) model, a cohesive theoretical framework that incorporates cognitive processes and human drivers (informed by psychology, cyberpsychology, and criminology theory). In 2021, a large-scale anonymous online survey was conducted across nine European countries. Criminal hacking was assessed using data from 3985 participants (M = 1895, 47.55%; F = 1968, 49.39%). This study formulated a powerful predictive model of youth hacking intention (accounting for 38.8% of the variance) and behaviour (accounting for 33.6% of the variance). A significant minority, approximately one in six (16.34%), were found to have engaged in hacking, and approximately 2% reported engaging in hacking often or very often. Increased age, being male, and offline deviant behaviour were significant predictors of hacking behaviour. In line with the TPB, intention was the strongest individual predictor of hacking behaviour, which in turn was significantly predicted by cognitive processes accounted for by TPB constructs: subjective norms of family and peers, attitudes towards hacking, and perceived behavioural control. These TPB constructs were found to be significantly associated with human factors of risk-taking, toxic online disinhibition, offline deviant behaviour, and demographic variables of age and gender. Implications for future research, interventions, policy, and practice are discussed

The relationship between dark triad personality traits and sexting behaviors among adolescents and young adults across 11 countries

Background: Sexting is an increasingly common phenomenon among adolescents and young adults. Some studies have investigated the role of personality traits in different sexting behaviors within mainstream personality taxonomies like Big Five and HEXACO. However, very few studies have investigated the role of maladaptive personality factors in sexting. Therefore, the present study investigated the relationship between Dark Triad Personality Traits and experimental (i.e., sharing own sexts), risky (i.e., sexting under substance use and with strangers), and aggravated sexting (i.e., non-consensual sexting and sexting under pressure) across 11 countries. Methods: An online survey was completed by 6093 participants (Mage = 20.35; SDage = 3.63) from 11 different countries which covered four continents (Europe, Asia, Africa, and America). Participants completed the Sexting Behaviors Questionnaire and the 12-item Dark Triad Dirty Dozen scale. Results: Hierarchical regression analyses showed that sharing own sexts was positively predicted by Machiavellianism and Narcissism. Both risky and aggravated sexting were positively predicted by Machiavellianism and Psychopathy. Conclusions: The present study provided empirical evidence that different sexting behaviors were predicted by Dark Triad Personality Traits, showing a relevant role of Machiavellian-ism in all kinds of investigated sexting behaviors. Research, clinical, and education implications for prevention programs are discussed

Major innovation in energy incumbents:a science-based design approach

The need to engage in major (e.g., radical) innovation efforts continues to challenge incumbents in established industries, despite the vast amount of scholarly work available on this subject. In this respect, a clear gap appears to exist between scholarly work and managerial practice. This gap can, at least partially, be attributed to the enormous dispersion of the field of innovation research as well as the descriptive/explanatory research lens prevailing in the field. In this paper, we aim to bridge this gap by adopting a science-based design approach, in order to systematically synthesize the fragmented knowledge base on major innovation into an evidence-based framework of design principles and action propositions. As such, this study serves to develop actionable knowledge for enhancing major innovation success for energy incumbents. We contribute to the literature in two ways. First, by using a research synthesis approach based on CIMO-logic, the study integrates and extends the various understandings of major innovation into a framework that spans organizational themes, functions and levels. Second, the study illustrates how these design principles can inform the development of innovation strategies and solutions in energy incumbents