Air temperature changes in Toruń (central Poland) from 1871 to 2010

The article presents a detailed analysis of changes in air temperature in Toruń in the period 1871–2010 on the basis of homogenised monthly, seasonal and annual air temperature series which have been newly constructed (i.e. extended by the 50 years of 1871–1920). Over the 140-year study period, a sizeable and statistically significant increase of 0.1 °C per decade was found in the air temperature in Toruń. The greatest increases occurred for spring and winter, at 0.12 and 0.11 °C, respectively. A lesser warming, meanwhile, was recorded for autumn (0.10 °C/10 years), and particularly for summer (0.07 °C/10 years). The air temperature trends are statistically significant for all seasons. Air temperature differences between the monthly averages of three analysed subperiods (1871–1900, 1901–1950 and 1951–2010) and averages for the entire period under review rarely exceeded ± 0.5 °C. In all of these periods, the highest average air temperatures occurred in July and the lowest in January. The period of 1981–2010 had the highest frequency of occurrence of very and extremely warm seasons and years. Meanwhile, the highest frequency of very and extremely cool seasons and years was recorded in the 1940s and in the nineteenth century. In the period of 1871–2010, winters shortened markedly (by 7%) and summers lengthened by 3.8%. All of the presented aspects of air temperature in Toruń, which is representative of the climate of central Poland, are in close agreement with the findings of analogous studies of the same for other areas of Poland and Central Europe

Variations in popliteal fossa venous anatomy: implications for diagnosis of deep-vein thrombosis

Background: To retrospectively review the bilateral venous system within the popliteal fossa to evaluate the types of variations and their frequency seen in venous anatomy.Materials and methods: During routine dissection of formalin-fixed cadavers, a retrospective review of 32 bilateral (64 limbs) lower limbs obtained from adult donors was performed. Deep veins present in the popliteal fossa were evaluated according to predetermined criteria for the presence of duplication of vessels and interindividual variations in venous anatomy.Results: More than one deep venous vessel was seen in the popliteal fossa in 20 (31.3%) of 64 limbs. In 12 (18.7%) cases there was a high (just below the level of the adductor hiatus) origin of the popliteal vein: from 2 tributaries in 10 (15.6%) and 3 tributaries in 2 (3.1%). In 5 (7.8%) cases true duplicated popliteal veins were observed. There were also 3 (4.7%) cases, including one bilateral, of persistent sciatic vein.Conclusions: Variations in popliteal fossa venous anatomy are common and have important implications for the diagnosis of deep vein thrombosis

Reduced level of synapsin I protein in the rat striatum after intraventricular administration of proteasome inhibitors: preliminary studies

Background: We have recently described changes present in nigrostriatal terminals after intraperitoneal administration of MG-132 and changes that occur in the walls of the rat lateral ventricle after intraventricular administration of MG-132, lactacystin and epoxomicin — different classes of proteasome inhibitors. Substances that inhibit ubiquitin-proteasome system (UPS) activity, are intensively studied due to their potential role as novel therapeutic strategies in the treatment of cancer and ischaemia-reperfusion injury in the brain. The aim of this study is to determine the influence of intraventricular administration of MG-132, lactacystin and epoxomicin on the level in the rat striatum synapsin I — one of the most prominent neuron-specific phosphoproteins in the brain. Materials and methods and Results: Two weeks after administration of studied proteasome inhibitors, substantial reduction (up to 80%) of synapsin I was ob­served in the rat striatum. Because neurons, and especially dopaminergic ones, are sensitive to the depletion of proteasome function, we assume that observed synapsin I decrease may reflect changes in population of striatal neurons and/or nigrostriatal terminals. Conclusions: Understanding of cellular mechanisms standing behind our findings needs further studies, and could provide valuable contribution to the discussion on the mechanisms linking UPS inhibition and survival of neurons.