Design and characterization of light field and holographic near-eye displays

The light field and holographic displays constitute two important categories of advanced three-dimensional displays that are aimed at delivering all physiological depth cues of the human visual system, such as stereo cues, motion parallax, and focus cues, with sufficient accuracy. As human observers are the end-users of such displays, the delivered spatial information (e.g., perceptual spatial resolution) and view-related image quality factors (e.g., focus cues) are significantly dependent on the characteristics of the human visual system. Retinal image formation models enable rigorous characterization and subsequently efficient design of light field and holographic displays. In this chapter the ray-based near-eye light field and wave-based near-eye holographic displays are reviewed, and the corresponding retinal image formation models are discussed. In particular, most of the discussion is devoted to characterization of the perceptual spatial resolution and focus cues.acceptedVersionPeer reviewe

Thickening agents used for dysphagia management: effect on bioavailability of water, medication and feelings of satiety

Dysphagia is the medical term for difficulty swallowing. Thickened liquids are often used in the management of dysphagia to improve bolus control and to help prevent aspiration. A range of starches and gums has historically been used to thicken liquids. Although thickened liquids improve swallow safety, they appear to have a great potential for unintended physiological consequences. Initial concerns were raised about the impact of thickeners on water binding due to the high prevalence of dehydration amongst individuals with dysphagia. Thankfully, regardless of thickening agent, thickeners do not affect water bioavailability. This effect holds true even for extremely thick fluids. However, bioavailability of medication is impaired with viscous substances. Liquids thickened to as little as 150 mPa.s retards drug release. In addition, feelings of satiety and thirst increase with increasingly viscous fluids. Flavour deteriorates with increasing thickness regardless of thickening agent. Therapeutically clinicians often prescribe small volumes of thickened liquids, consumed often. Yet small volumes of thick substances consumed with a long oral processing time, which is common for individuals with dysphagia, reduces the amount consumed. A combination of poor flavour, and increasing feelings of fullness result in little motivation and poor physiologic drive to consume thickened liquids.This review provides evidence from the dysphagia, pharmaceutical and food technology literature to show unintended side effects of thickened liquids that contribute to dehydration and potential sub-theraputic medication levels for individuals with dysphagia. The physical property of viscosity rather than a particular thickening agent appears to be key. Provision of "spoon-thick" or "extremely thick liquids" is particularly likely to contribute to dehydration and poor bioavailability of solid dose medication. Clinicians are encouraged to prescribe the minimal level of thickness needed for swallowing safety. Consultation with pharmacy and dietetic staff is essential for optimum management of individuals with dysphagia. Given the aged population forecasts for the year 2050, improved dysphagia management should be a high priority