Global Management Effectiveness Study: Integrated Social and Ecological Report for Non-node and Node Sites

The purpose of this study is to provide a critical assessment of the implementation, impact, and performance of Marine Managed Area (MMA) projects to serve as a basis for improved planning and implementation of new MMA projects worldwide. The specific objectives of the study are (1) to determine the socioeconomic, governance and ecological effects of MMAs; (2) to determine the critical factors influencing MMA effects, as well as the impact of the timing of those factors on the effects of the MMA; and (3) to provide tools for predicting MMA effects based on ecological, socioeconomic and governance variable

A comparative study of Mackay-Marg, Durham-Langham and Tonomat tonometry

A comparative study of Mackay-Marg, Durham-Langham and Tonomat tonometr

Piloting a holistic information culture program: The experience of CETYS Universidad system of libraries

This article presents the staff, structure, methods and preliminary results from the pilot of a holistic information literacy program developed in the System of Libraries of CETYS Universidad in Mexico. ‘Information Culture Development’ (ICD) is driven by action research (AR) and the concept of information culture (IC), comprised of information literacy (IL), digital literacy (DL), and research competences. ICD aims at developing these competences and supporting reflection and improvement upon university practices related to curriculum, teaching, and research. ICD’s initiatives and products were divided into four axes: a) curriculum and learning support, b) information and digital literacies development, c) research and scientific communication support, and d) evaluation and communication of results. ICD’s pilot involved workshops and activities framed within an AR perspective and a mixed methods approach. Preliminary results determine the success of activities with academics and students regarding their strengths and weaknesses in IC-related competencies

Photoinduced transient stark spectroscopy in organic semiconductors: a method for charge mobility determination in the picosecond regime.

Published versio

Structural and biophysical properties of a synthetic channel-forming peptide: designing a clinically relevant anion selective pore

The design, synthesis, modeling and in vitro testing of channel-forming peptides derived from the cys-loop superfamily of ligand-gated ion channels are part of an ongoing research focus. Over 300 different sequences have been prepared based on the M2 transmembrane segment of the spinal cord glycine receptor α-subunit. A number of these sequences are water-soluble monomers that readily insert into biological membranes where they undergo supramolecular assembly, yielding channels with a range of selectivities and conductances. Selection of a sequence for further modifications to yield an optimal lead compound came down to a few key biophysical properties: low solution concentrations that yield channel activity, greater ensemble conductance, and enhanced ion selectivity. The sequence NK[subscript]4-M2GlyR T19R, S22W (KKKKPARVGLGITTVLTMRTQW) addressed these criteria. The structure of this peptide has been analyzed by solution NMR as a monomer in detergent micelles, simulated as five-helix bundles in a membrane environment, modified by cysteine-scanning and studied for insertion efficiency in liposomes of selected lipid compositions. Taken together, these results define the structural and key biophysical properties of this sequence in a membrane. This model provides an initial scaffold from which rational substitutions can be proposed and tested to modulate anion selectivity. This article is part of a Special Issue entitled: Protein Folding in Membranes