589 research outputs found
Two-dimensional Moist Stratified Turbulence and the Emergence of Vertically Sheared Horizontal Flows
Moist stratified turbulence is studied in a two-dimensional Boussinesq system
influenced by condensation and evaporation. The problem is set in a periodic
domain and employs simple evaporation and condensation schemes, wherein both
the processes push parcels towards saturation. Numerical simulations
demonstrate the emergence of a moist turbulent state consisting of ordered
structures with a clear power-law type spectral scaling from initially
spatially uncorrelated conditions. An asymptotic analysis in the limit of rapid
condensation and strong stratification shows that, for initial conditions with
enough water substance to saturate the domain, the equations support a
straightforward state of moist balance characterized by a hydrostatic,
saturated, vertically sheared horizontal flow (VSHF). For such initial
conditions, by means of long time numerical simulations, the emergence of moist
balance is verified. Specifically, starting from uncorrelated data, subsequent
to the development of a moist turbulent state, the system experiences a rather
abrupt transition to a regime which is close to saturation and dominated by a
strong VSHF. On the other hand, initial conditions which do not have enough
water substance to saturate the domain, do not attain moist balance. Rather,
the system remains in a turbulent state and oscillates about moist balance.
Even though balance is not achieved with these general initial conditions, the
time scale of oscillation about moist balance is much larger than the imposed
time scale of condensation and evaporation, thus indicating a distinct dominant
slow component in the moist stratified two-dimensional turbulent system.Comment: 23 pages. 9 figure
Fluvoxamine: A review of its mechanism of action and its role in COVID-19
Fluvoxamine is a well-tolerated, widely available, inexpensive selective serotonin reuptake inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized study to prevent clinical deterioration of patients with mild coronavirus disease 2019 (COVID-19). Fluvoxamine is also an agonist for the sigma-1 receptor, through which it controls inflammation. We review here a body of literature that shows important mechanisms of action of fluvoxamine and other SSRIs that could play a role in COVID-19 treatment. These effects include: reduction in platelet aggregation, decreased mast cell degranulation, interference with endolysosomal viral trafficking, regulation of inositol-requiring enzyme 1α-driven inflammation and increased melatonin levels, which collectively have a direct antiviral effect, regulate coagulopathy or mitigate cytokine storm, which are known hallmarks of severe COVID-19
Vortical and Wave Modes in 3D Rotating Stratified Flows: Random Large Scale Forcing
Utilizing an eigenfunction decomposition, we study the growth and spectra of
energy in the vortical and wave modes of a 3D rotating stratified fluid as a
function of . Working in regimes characterized by moderate
Burger numbers, i.e. or , our results
indicate profound change in the character of vortical and wave mode
interactions with respect to . As with the reference state of
, for the wave mode energy saturates quite quickly
and the ensuing forward cascade continues to act as an efficient means of
dissipating ageostrophic energy. Further, these saturated spectra steepen as
decreases: we see a shift from to scaling for
(where and are the forcing and dissipation scales,
respectively). On the other hand, when the wave mode energy
never saturates and comes to dominate the total energy in the system. In fact,
in a sense the wave modes behave in an asymmetric manner about .
With regard to the vortical modes, for , the signatures of 3D
quasigeostrophy are clearly evident. Specifically, we see a scaling
for and, in accord with an inverse transfer of energy, the
vortical mode energy never saturates but rather increases for all . In
contrast, for and increasing, the vortical modes contain a
progressively smaller fraction of the total energy indicating that the 3D
quasigeostrophic subsystem plays an energetically smaller role in the overall
dynamics.Comment: 18 pages, 6 figs. (abbreviated abstract
Correction for Self-Heating When Using Thermometers as Heaters in Precision Control Applications
In precision control applications, thermometers have temperature-dependent electrical resistance with germanium or other semiconductor material thermistors, diodes, metal film and wire, or carbon film resistors. Because resistance readout requires excitation current flowing through the sensor, there is always ohmic heating that leads to a temperature difference between the sensing element and the monitored object. In this work, a thermistor can be operated as a thermometer and a heater, simultaneously, by continuously measuring the excitation current and the corresponding voltage. This work involves a method of temperature readout where the temperature offset due to self-heating is subtracted exactly
New Shape Invariant Potentials in Supersymmetric Quantum Mechanics
Quantum mechanical potentials satisfying the property of shape invariance are
well known to be algebraically solvable. Using a scaling ansatz for the change
of parameters, we obtain a large class of new shape invariant potentials which
are reflectionless and possess an infinite number of bound states. They can be
viewed as q-deformations of the single soliton solution corresponding to the
Rosen-Morse potential. Explicit expressions for energy eigenvalues,
eigenfunctions and transmission coefficients are given. Included in our
potentials as a special case is the self-similar potential recently discussed
by Shabat and Spiridonov.Comment: 8pages, Te
Readily available drugs and other interventions to potentially improve the efficacy of immune checkpoint blockade in cancer
To improve the efficacy of immune checkpoint inhibitors (ICIs) for cancer treatment, various strategies, including combination therapies with repurposed drugs, are being explored. Several readily available interventions with potential to enhance programmed death 1 (PD-1) blockade have been identified. However, these interventions often remain overlooked due to the lack of financial incentives for their development, making them financial orphans. This review summarizes current knowledge regarding off-label drugs, supplements, and other readily available interventions that could improve the efficacy of PD-1 blockade. The summary of each intervention includes the proposed mechanism of action for combination with checkpoint inhibitors and data from animal and human studies. Additionally, we include summaries of common interventions to be avoided by patients on PD-1 blockade. Finally, we present approaches for conducting further studies in patients, with the aim of expediting the clinical development of these interventions. We strive to increase awareness of readily available combination therapies that may advance cancer immunotherapy and help patients today
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