14 research outputs found
Mean differences (SE) in DNA methylation levels associated with income, wealth, education, and childhood SES.
*<p>β=β p<0.05, ** β=β p<0.01, *** β=β p<0.001.</p
Mean differences (SE) in DNA methylation levels associated with age, gender and race.
β <p>SES indicators adjusted were: income, wealth, education, childhood SES.</p>*<p>β=β p<0.05, ** β=β p<0.01, *** β=β p<0.001.</p
Sample characteristics (%) and mean (SD) of Alu and LINE-1 methylation across categories of age, race/ethnicity, income, wealth, education, and childhood SES in the study sample.
β‘<p>Childhood SES: Low β=β less than high school, medium β=β high school degree, high β=β some college or more. <b><sup>β </sup></b>Missing in Alu and LINE-1 samples: Income (14), wealth (3), childhood SES (39 in Alu, 37 in LINE-1) * β=β p<0.05, ** β=β p<0.01, *** β=β p<0.001.</p
Newborn global DNA methylation and maternal urinary As exposure.
<p>Mean (SE) newborn global methylation levels as measured by the methyl-incorporation assay by quartiles of maternal uAs exposure adjusted for the sex-specific effect of uCrn. * Q1 and Q2 vs. Q4; pβ=β0.06 and 0.04, respectively.</p
Demographics and clinical data of the study population.
a<p>Values are mean (SD).</p>b<p>Nβ=β100,</p>c<p>Nβ=β99,</p>d<p>Nβ=β95,</p>e<p>Nβ=β57,</p>f<p>Nβ=β56,</p>g<p>Nβ=β54,</p>h<p>Nβ=β42,</p>i<p>Nβ=β41,</p>j<p>Nβ=β40,</p>k<p>Nβ=β37.</p>*<p>P<0.05; Wilcoxon rank sum test for differences between newborn sex.</p>**<p>P<0.01; Wilcoxon rank sum test for differences between newborn sex.</p
Spearman correlation coefficients for global DNA methylation between maternal vs. newborn pairs, combined and stratified by newborn sex.
*<p>p<0.05;</p>**<p>p<0.01.</p
Estimated parameter for associations between biomarkers of As exposure and newborn global DNA methylation assays combined and stratified by sex.
1<p>Sex- specific effect of uCrn was controlled in the models for DPM/DNA, Alu and Line-1.</p>2<p>Interaction by newborn sex.</p
Spearman correlation coefficients for newborn global DNA methylation vs. urinary creatinine and indicators of one-carbon metabolism in plasma, combined and stratified by newborn sex.
*<p>p<0.05;</p>**<p>p<0.01.</p>a<p>p<0.05;</p>b<p>p<0.01 from Wald test for sex differences in correlations.</p
Prevalence of chronic kidney disease (CKD) stages by gender.
<p>Prevalence of chronic kidney disease (CKD) stages by gender.</p
Characteristics of the study samples.
a<p>Chi-square and Wilcoxon's rank-sum tests were used to test for between sample differences in categorical and continuous variables, respectively.</p>b<p>2001 sample Nβ=β366, 2003 sample Nβ=β109.</p>c<p>%DMA, %MMA, and %InAs, the proportion of total urinary arsenic excreted as dimethylarsinic acid, monomethylarsonic acid, and inorganic arsenic, respectively.</p>d<p>2003 sample Nβ=β109.</p>e<p>tHcys, total homocysteine.</p>f<p>Defined as trace protein or greater in urine by dipstick test.</p>g<p>2001 sample Nβ=β365.</p>h<p>2001 sample Nβ=β344.</p><p>Characteristics of the study samples.</p