PENERAPAN FUNGSI MANAJEMEN DALAM KELOMPOK TANI CEMPAKA

The research aims to see how the implementation of management function in Cempaka farmer group in Meras Urban Village of Bunaken Sub-district of Manado City, by using Likert Scale concept to describe the implementation of management function which includes four functions (planning, organizing, implementation and evaluation). This research was conducted from February to June 2017. Data collection was primary data and secondary data. Primary data was obtained through direct interviews to 15 respondents using questionnaires and secondary data obtained from Meras Kelurahan Office. The sampling technique is Purposive Sampling that respondents are all members and managers of farmer group Cempaka. The resulting data is presented in tabular form and analyzed by Likert scale then described or describes the management function expectation in Cempaka farmer group. The results showed that the percentage of implementation of management function in Cempaka farmer group is 84,49% meaning the implementation of management functions that begin with planning work, finance or division of tasks in of each field to carry out what the work plan and evaluate the work of the group is in accordance with the function of management.*eprm

High-Energy Approach for Heavy-Ion Scattering with Excitations of Nuclear Collective States

A phenomenological optical potential is generalized to include the Coulomb and nuclear interactions caused by the dynamical deformation of its surface. In the high-energy approach analytical expressions for elastic and inelastic scattering amplitudes are obtained where all the orders in the deformation parameters are included. The multistep effect of the 2$^+$ rotational state excitation on elastic scattering is analyzed. Calculations of inelastic cross sections for the $^{17}$O ions scattered on different nuclei at about hundred Mev/nucleon are compared with experimental data, and important role of the Coulomb excitation is established.Comment: 9 pages; 3 figures. Submitted to the Physics of Atomic Nucle

MicroRNA-4732-3p Is Dysregulated in Breast Cancer Patients with Cardiotoxicity, and Its Therapeutic Delivery Protects the Heart from Doxorubicin-Induced Oxidative Stress in Rats

Anthracycline-induced cardiotoxicity is the most severe collateral effect of chemotherapy originated by an excess of oxidative stress in cardiomyocytes that leads to cardiac dysfunction. We assessed clinical data from patients with breast cancer receiving anthracyclines and searched for discriminating microRNAs between patients that developed cardiotoxicity (cases) and those that did not (controls), using RNA sequencing and regression analysis. Serum levels of 25 microRNAs were differentially expressed in cases versus controls within the first year after anthracycline treatment, as assessed by three different regression models (elastic net, Robinson and Smyth exact negative binomial test and random forest). MiR-4732-3p was the only microRNA identified in all regression models and was downregulated in patients that experienced cardiotoxicity. MiR-4732-3p was also present in neonatal rat cardiomyocytes and cardiac fibroblasts and was modulated by anthracycline treatment. A miR-4732-3p mimic was cardioprotective in cardiac and fibroblast cultures, following doxorubicin challenge, in terms of cell viability and ROS levels. Notably, administration of the miR-4732-3p mimic in doxorubicin-treated rats preserved cardiac function, normalized weight loss, induced angiogenesis, and decreased apoptosis, interstitial fibrosis and cardiac myofibroblasts. At the molecular level, miR-4732-3p regulated genes of TGF beta and Hippo signaling pathways. Overall, the results indicate that miR-4732-3p is a novel biomarker of cardiotoxicity that has therapeutic potential against anthracycline-induced heart damage

MicroRNA-4732-3p Is Dysregulated in Breast Cancer Patients with Cardiotoxicity, and Its Therapeutic Delivery Protects the Heart from Doxorubicin-Induced Oxidative Stress in Rats

Anthracycline-induced cardiotoxicity is the most severe collateral effect of chemotherapy originated by an excess of oxidative stress in cardiomyocytes that leads to cardiac dysfunction. We assessed clinical data from patients with breast cancer receiving anthracyclines and searched for discriminating microRNAs between patients that developed cardiotoxicity (cases) and those that did not (controls), using RNA sequencing and regression analysis. Serum levels of 25 microRNAs were differentially expressed in cases versus controls within the first year after anthracycline treatment, as assessed by three different regression models (elastic net, Robinson and Smyth exact negative binomial test and random forest). MiR-4732-3p was the only microRNA identified in all regression models and was downregulated in patients that experienced cardiotoxicity. MiR-4732-3p was also present in neonatal rat cardiomyocytes and cardiac fibroblasts and was modulated by anthracycline treatment. A miR-4732-3p mimic was cardioprotective in cardiac and fibroblast cultures, following doxorubicin challenge, in terms of cell viability and ROS levels. Notably, administration of the miR-4732-3p mimic in doxorubicin-treated rats preserved cardiac function, normalized weight loss, induced angiogenesis, and decreased apoptosis, interstitial fibrosis and cardiac myofibroblasts. At the molecular level, miR-4732-3p regulated genes of TGFβ and Hippo signaling pathways. Overall, the results indicate that miR-4732-3p is a novel biomarker of cardiotoxicity that has therapeutic potential against anthracycline-induced heart damage