Kosten voor habitattypen in Natura 2000-gebieden : toepassing van de methode Kosteneffectiviteit natuurbeleid

Deze studie beschrijft de berekening van de kosten voor het natuurbeleid in de Natura 2000-gebieden, gebaseerd op de aanwezige habitattypen. De kosten zijn afgeleid van het benodigde beheer en de milieutekorten rond vermesting en verdroging. De ligging van de habitattypen is bepaald op basis van het koppelingsbestand ´ecotopen en habitattypen´ en op basis van de stikstofdepositie. In totaal gaat het om een areaal van 56.922 ha. De gemiddelde kosten voor het realiseren van de habitattypen liggen bij 800 euro/ha/jaar, variërend van ruim 100 euro/ha/jaar in Groningen tot 3.250 euro/ha/jaar in Utrecht. Door een andere manier van toewijzing van de habitattypen verschillen de in de huidige studie berekende kosten en arealen met milieutekorten van die uit de eerdere studie naar de kosten van de Natura 2000-gebieden

Implications of quantitative susceptibility mapping at 7 Tesla MRI for microbleeds detection in cerebral small vessel disease

BACKGROUND: Cerebral microbleeds (MBs) are a hallmark of cerebral small vessel disease (CSVD) and can be found on T2*-weighted sequences on MRI. Quantitative susceptibility mapping (QSM) is a postprocessing method that also enables MBs identification and furthermore allows to differentiate them from calcifications. AIMS: We explored the implications of using QSM at submillimeter resolution for MBs detection in CSVD. METHODS: Both 3 and 7 Tesla (T) MRI were performed in elderly participants without MBs and patients with CSVD. MBs were quantified on T2*-weighted imaging and QSM. Differences in the number of MBs were assessed, and subjects were classified in CSVD subgroups or controls both on 3T T2*-weighted imaging and 7T QSM. RESULTS: 48 participants [mean age (SD) 70.9 (8.8) years, 48% females] were included: 31 were healthy controls, 6 probable cerebral amyloid angiopathy (CAA), 9 mixed CSVD, and 2 were hypertensive arteriopathy [HA] patients. After accounting for the higher number of MBs detected at 7T QSM (Median = Mdn; Mdn7T−QSM = 2.5; Mdn3T−T2 = 0; z = 4.90; p < 0.001) and false positive MBs (6.1% calcifications), most healthy controls (80.6%) demonstrated at least one MB and more MBs were discovered in the CSVD group. CONCLUSIONS: Our observations suggest that QSM at submillimeter resolution improves the detection of MBs in the elderly human brain. A higher prevalence of MBs than so far known in healthy elderly was revealed

Detection of Cerebral Microbleeds With Venous Connection at 7-Tesla MRI

Objective: Cerebral microbleeds (MBs) are a common finding in patients with cerebral small vessel disease (CSVD) and Alzheimer disease as well as in healthy elderly people, but their pathophysiology remains unclear. To investigate a possible role of veins in the development of MBs, we performed an exploratory study, assessing in vivo presence of MBs with a direct connection to a vein. Methods: 7-Tesla (7T) MRI was conducted and MBs were counted on quantitative susceptibility mapping (QSM). A submillimeter resolution QSM-based venogram allowed identification of MBs with a direct spatial connection to a vein. Results: A total of 51 people (mean age [SD] 70.5 [8.6] years, 37% female) participated in the study: 20 had CSVD (cerebral amyloid angiopathy [CAA] with strictly lobar MBs [n = 8], hypertensive arteriopathy [HA] with strictly deep MBs [n = 5], or mixed lobar and deep MBs [n = 7], 72.4 [6.1] years, 30% female) and 31 were healthy controls (69.4 [9.9] years, 42% female). In our cohort, we counted a total of 96 MBs with a venous connection, representing 14% of all detected MBs on 7T QSM. Most venous MBs (86%, n = 83) were observed in lobar locations and all of these were cortical. Patients with CAA showed the highest ratio of venous to total MBs (19%) (HA = 9%, mixed = 18%, controls = 5%). Conclusion: Our findings establish a link between cerebral MBs and the venous vasculature, pointing towards a possible contribution of veins to CSVD in general and to CAA in particular. Pathologic studies are needed to confirm our observations

Hippocampal vascular reserve associated with cognitive performance and hippocampal volume

Medial temporal lobe dependent cognitive functions are highly vulnerable to hypoxia in the hippocampal region, yet little is known about the relationship between the richness of hippocampal vascular supply and cognition. Hippocampal vascularization patterns have been categorized into a mixed supply from both the posterior cerebral artery and the anterior choroidal artery or a single supply by the posterior cerebral artery only. Hippocampal arteries are small and affected by pathological changes when cerebral small vessel disease is present. We hypothesized, that hippocampal vascularization patterns may be important trait markers for vascular reserve and modulate (i) cognitive performance; (ii) structural hippocampal integrity; and (iii) the effect of cerebral small vessel disease on cognition. Using high-resolution 7 T time-of-flight angiography we manually classified hippocampal vascularization patterns in older adults with and without cerebral small vessel disease in vivo. The presence of a mixed supplied hippocampus was an advantage in several cognitive domains, including verbal list learning and global cognition. A mixed supplied hippocampus also was an advantage for verbal memory performance in cerebral small vessel disease. Voxel-based morphometry showed higher anterior hippocampal grey matter volume in mixed, compared to single supply. We discuss that a mixed hippocampal supply, as opposed to a single one, may increase the reliability of hippocampal blood supply and thereby provide a hippocampal vascular reserve that protects against cognitive impairment

Market signals for organic farming

The organic material price project studies the methods and tools to improve the provision of information on 'Economic opportunities for organic farming in the EU Member Countries'. An important issue is the improvement of the quality and the speed of relevant information for policy purposes, for statistics and research on the farm sector. The report presents proposals on this as well as the results of analyses on (1) the relationship between the prices of organic products and prices of conventional products; (2) economic results of organic compared to similar sized conventional farms

Immigrant integration in Western Europe: then and now

Book synopsis: In the 1990s, as concern grew in the United States about the integration of large numbers of immigrants, scholars searching for historical parallels looked to the last great period of immigration, ffrom 1880 to 1914. That example, however, is generally viewed as inapplicable to the current immigration debates in Europe. Paths of Integration turns this conventional wisdom on its head, arguing that the history of European migration more closely parallels the U.S. experience than most realize, due to the largely ignored, but extensive, intra-European migration of the same period. By placing the European and U.S. examples side by side, the contributors to this volume offer long-term insights on a question that will be of great importance in the coming decades