Airway CD8+CD8^+ T Cells Induced by Pulmonary DNA Immunization Mediate Protective Anti-Viral Immunity

Vaccination strategies for protection against a number of respiratory pathogens must induce T-cell populations in both the pulmonary airways and peripheral lymphoid organs. In this study, we show that pulmonary immunization using plasmid DNA formulated with the polymer polyethyleneimine (PEI-DNA) induced antigen-specific $CD8^+$ T cells in the airways that persisted long after antigen local clearance. The persistence of the cells was not mediated by local lymphocyte proliferation or persistent antigen presentation within the lung or airways. These vaccine-induced $CD8^+$ T cells effectively mediated protective immunity against respiratory challenges with vaccinia virus and influenza virus. Moreover, this protection was not dependent upon the recruitment of T cells from peripheral sites. These findings demonstrate that pulmonary immunization with PEI-DNA is an efficient approach for inducing robust pulmonary $CD8^+$ T-cell populations that are effective at protecting against respiratory pathogens

Positive pion absorption on 3He using modern trinucleon wave functions

We study pion absorption on 3He employing trinucleon wave functions calculated from modern realistic NN interactions (Paris, CD Bonn). Even though the use of the new wave functions leads to a significant improvement over older calculations with regard to both cross section and polarization data, there are hints that polarization data with quasifree kinematics cannot be described by just two-nucleon absorption mechanisms.Comment: 14 pages, 6 figure

Experimental evaluation of an adaptive Joule--Thomson cooling system including silicon-microfabricated heat exchanger and microvalve components

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/98726/1/JVA021005.pd

Search for the Flavor-Changing Neutral-Current Decays D+→π+μ+μ−D^+\to \pi^+ \mu^+ \mu^- and D+→π+e+e−D^+\to \pi^+ e^+ e^-

We report the results of a search for the flavor-changing neutral-current decays $D^+\rightarrow \pi^+ \mu^+ \mu^-$ and $D^+\rightarrow \pi^+ e^+ e^-$ in data from Fermilab charm hadroproduction experiment E791. No signal above background is found, and we obtain upper limits on branching fractions, $B(D^+\rightarrow \pi^+ \mu^+ \mu^-) < 1.8 \times 10^{-5}$ and $B(D^+\rightarrow \pi^+ e^+ e^-) < 6.6 \times 10^{-5}$, at the 90\% confidence level.Comment: nine pages with figures; compressed, uuencoded postscrip

Measurement of the Ds Lifetime

We report the results of a precise measurement of the Ds meson lifetime based on 1662 +/- 56 fully reconstructed Ds -> phi pi decays, from the charm hadroproduction experiment E791 at Fermilab. Using an unbinned maximum likelihood fit, we measure the Ds lifetime to be 0.518 +/- 0.014 +/- 0.007 ps. The ratio of the measured Ds lifetime to the world average D0 lifetime is 1.25 +/- 0.04. This result differs from unity by six standard deviations, indicating significantly different lifetimes for the Ds and the D0.Comment: 12 pages, 3 figures, 2 table. LaTe

Direct measurement of the pion valence quark momentum distribution, the pion light-cone wave function squared

We present the first direct measurements of the pion valence quark momentum distribution which is related to the square of the pion light-cone wave function. The measurements were carried out using data on diffractive dissociation of 500 GeV/c $\pi^-$ into di-jets from a platinum target at Fermilab experiment E791. The results show that the $|q\bar {q}>$ light-cone asymptotic wave function, which was developed using perturbative QCD methods, describes the data well for $Q^2 \sim 10 ~{\rm (GeV/c)^2}$ or more. We also measured the transverse momentum distribution of the diffractive di-jets.Comment: 13 pages, 4 figure

Study of the Ds+→π−π+π+D^+_s \to \pi^- \pi^+ \pi^+ decay and measurement of f0f_0 masses and widths

From a sample of 848 $\pm$ 44 $D_s^+ \to \pi^- \pi^+ \pi^+$ decays, we find $\Gamma(D_s^+ \to \pi^- \pi^+ \pi^+) / \Gamma(D_s^+ \to \phi \pi^+) = 0.245 \pm 0.028^{+0.019}_{-0.012}$. Using a Dalitz plot analysis of this three body decay, we find significant contributions from the channels $\rho^0(770)\pi^+$, $\rho^0(1450)\pi^+$, $f_0(980)\pi^+$, $f_2(1270)\pi^+$, and $f_0(1370)\pi^+$. We present also the values obtained for masses and widths of the resonances $f_0(980)$ and $f_0(1370)$.Comment: 10 pages, 3 eps figure

Experimental evidence for a light and broad scalar resonance in D+→π−π+π+D^+\to \pi^-\pi^+\pi^+ decay

From a sample of $1172 \pm 61$ $D^+ \to \pi^- \pi^+ \pi^+$ decay, we find $\Gamma (D^+ \to \pi^- \pi^+ \pi^+) / \Gamma (D^+ \to K^- \pi^+ \pi^+) = 0.0311 \pm 0.0018 ^{+0.0016}_{-0.0026}$. Using a coherent amplitude analysis to fit the Dalitz plot of this decays, we find strong evidence that a scalar resonance of mass $478^{+24}_{-23} \pm 17$ MeV/$c^2$ and width $324^{+42}_{-40} \pm 21$ MeV/$c^2$ accounts for approximately half of all decays.Comment: 10 pages, 3 eps figure

Dalitz Plot Analysis of the Decay D^+ --> K^- pi^+ pi^+ and Indication of a Low-Mass Scalar K pi Resonance

We study the Dalitz plot of the decay D^+ --> K^- pi^+ pi^+ with a sample of 15090 events from Fermilab experiment E791. Modeling the decay amplitude as the coherent sum of known K pi resonances and a uniform nonresonant term, we do not obtain an acceptable fit. If we allow the mass and width of the K^*_0(1430) to float, we obtain values consistent with those from PDG but the chi^2 per degree of freedom of the fit is still unsatisfactory. A good fit is found when we allow for the presence of an additional scalar resonance, with mass 797 +/- 19 +/- 43 MeV/c^2 and width 410 +/- 43 +/- 87 MeV/c^2. The mass and width of the K^*_0(1430) become 1459 +/- 7 +/- 5 MeV/c^2 and 175 +/- 12 +/- 12 MeV/c^2, respectively. Our results provide new information on the scalar sector in hadron spectroscopy.Comment: Accepted for publication in Physical Review Letter