The use of genetic algorithms to maximize the performance of a partially lined screened room

This paper shows that it is possible to use genetic algorithms to optimize the layout of ferrite tile absorber in a partially lined screened enclosure to produce a "best" performance. The enclosure and absorber are modeled using TLM modeling techniques and the performance is determined by comparison with theoretical normalized site attenuation of free space. The results show that it is possible to cover just 80% of the surface of the enclosure with ferrite absorber and obtain a response which is within +/-4 dB of the free space response between 40 and 200 MHz

Cohort profile of the UK Biobank: diagnosis and characteristics of cerebrovascular disease

Purpose: The UK Biobank is a large-scale biomedical resource, containing sociodemographic and medical information, including data on a previous diagnosis of stroke or transient ischaemic attack (TIA). We described these participants and their medication usage. Participants: We identified participants who either self-reported or were identified from a nurse-led interview, having suffered a stroke or a TIA and compared them against participants without stroke ort TIA. We assessed their risk factor burden (sex, age, deprivation, waist to hip ratio (WHR), hypertension, smoking, alcohol intake, diabetes, physical exercise and oral contraception use (oral contraceptive pill, OCP)) and medication usage. Findings: to date We studied 502 650 people (54.41% women), 6669 (1.23%) participants self-reported a stroke. The nurse-led interview identified 7669 (1.53%) people with stroke and 1781 (0.35%) with TIA. Hypertension, smoking, higher WHR, lower alcohol consumption and diabetes were all more common in people with cerebrovascular disease (p<0.0001 for each). Women with cerebrovascular disease were less likely to have taken the OCP (p=0.0002). People with cerebrovascular disease did more exercise (p=0.03). Antithrombotic medication was taken by 81% of people with stroke (both self-report and nurse-led responders) and 89% with TIA. For self-reported stroke, 63% were taking antithrombotic and cholesterol medications, 54% taking antithrombotic and antihypertensive medications and 46% taking all 3. For the nurse-led interview and TIA, these figures were 65%, 54% and 46%, and 70%, 53% and 45%, respectively. Future plans: The UK Biobank provides a large, generalisable and contemporary data source in a young population. The characterisation of the UK Biobank cohort with cerebrovascular disease will form the basis for ongoing research using this data source

Exact relaxation in a class of non-equilibrium quantum lattice systems

A reasonable physical intuition in the study of interacting quantum systems says that, independent of the initial state, the system will tend to equilibrate. In this work we study a setting where relaxation to a steady state is exact, namely for the Bose-Hubbard model where the system is quenched from a Mott quantum phase to the strong superfluid regime. We find that the evolving state locally relaxes to a steady state with maximum entropy constrained by second moments, maximizing the entanglement, to a state which is different from the thermal state of the new Hamiltonian. Remarkably, in the infinite system limit this relaxation is true for all large times, and no time average is necessary. For large but finite system size we give a time interval for which the system locally "looks relaxed" up to a prescribed error. Our argument includes a central limit theorem for harmonic systems and exploits the finite speed of sound. Additionally, we show that for all periodic initial configurations, reminiscent of charge density waves, the system relaxes locally. We sketch experimentally accessible signatures in optical lattices as well as implications for the foundations of quantum statistical mechanics.Comment: 8 pages, 3 figures, replaced with final versio

Reliability of the modified Rankin Scale: a systematic review

<p><b>Background and Purpose:</b> A perceived weakness of the modified Rankin Scale is potential for interobserver variability. We undertook a systematic review of modified Rankin Scale reliability studies.</p> <p><b>Methods:</b> Two researchers independently reviewed the literature. Crossdisciplinary electronic databases were interrogated using the following key words: Stroke*; Cerebrovasc*; Modified Rankin*; Rankin Scale*; Oxford Handicap*; Observer variation*. Data were extracted according to prespecified criteria with decisions on inclusion by consensus.</p> <p><b>Results:</b> From 3461 titles, 10 studies (587 patients) were included. Reliability of modified Rankin Scale varied from weighted κ=0.95 to κ=0.25. Overall reliability of mRS was κ=0.46; weighted κ=0.90 (traditional modified Rankin Scale) and κ=0.62; weighted κ=0.87 (structured interview).</p> <p><b>Conclusion:</b> There remains uncertainty regarding modified Rankin Scale reliability. Interobserver studies closest in design to large-scale clinical trials demonstrate potentially significant interobserver variability.</p&gt

Exploring the reliability of the modified Rankin Scale

<p><b>Background and Purpose:</b> The modified Rankin Scale (mRS) is the most prevalent outcome measure in stroke trials. Use of the mRS may be hampered by variability in grading. Previous estimates of the properties of the mRS have used diverse methodologies and may not apply to contemporary trial populations. We used a mock clinical trial design to explore inter- and intraobserver variability of the mRS.</p> <p><b>Methods:</b> Consenting patients with stroke attending for outpatient review had the mRS performed by 2 independent assessors with pairs of assessors selected from a team of 3 research nurses and 4 stroke physicians. Before formal assessment, interviewers estimated disability based only on initial patient observation. Each patient was then randomized to undergo the mRS using standard assessment or a prespecified structured interview. The second interviewer in the pair reassessed the patient using the same method blinded to the colleague’s score. For each patient assessed, one rater was randomly assigned to video record their interview. After 3 months, this interviewer reviewed and regraded their original video assessment.</p> <p><b>Results:</b> Across 100 paired assessments, interobserver agreement was moderate (k=0.57). Intraobserver variability was good (k=0.72) but less than would be expected from previous literature. Forty-nine assessments were performed using the structured interview approach with no significant difference between structured and standard mRS. Researchers were unable to reliably predict mRS from initial limited patient assessment (k=0.16).</p> <p><b>Conclusions:</b> Despite availability of training and structured interview, there remains substantial interobserver variability in mRS grades awarded even by experienced researchers. Additional methods to improve mRS reliability are required.</p&gt

D1 and D5-Brane Actions in AdS_m x S^n

The kappa-invariant and supersymmetric actions of D1 and D5-branes in AdS_3 x S^3 are investigated, as well as the action of a D5-brane in an AdS_5 x S^5 background. The action of a D5-brane lying totally in an AdS_3 x S^3 background is found. Some progress was made towards finding the action for the D5-brane free to move in the whole AdS_3 x S^3 x T^4 space, however the supersymmetric action found here is not kappa-invariant and the reasons the method used did not find a kappa-invariant solution are discussed.Comment: 17pp, Latex, improved explanations, a definition adde

Variability in modified rankin scoring across a large cohort of observers

<br>Background and Purpose— The modified Rankin scale (mRS) is the most commonly used outcome measure in stroke trials. However, substantial interobserver variability in mRS scoring has been reported. These studies likely underestimate the variability present in multicenter clinical trials, because exploratory work has only been undertaken in single centers by a few observers, all of similar training. We examined mRS variability across a large cohort of international observers using data from a video training resource.</br> <br>Methods— The mRS training package includes a series of “real-life” patient interviews for grading. Training data were collected centrally and analyzed for variability using kappa statistics. We examined variability against a standard of “correct” mRS grades; examined variability by country; and for UK assessors, examined variability by center and by professional background of the observer.</br> <br>Results— To date, 2942 assessments from 30 countries have been submitted. Overall reliability for mRS grading has been moderate to good with substantial heterogeneity across countries. Native English language has had little effect on reliability. Within the United Kingdom, there was no significant variation by profession.</br> <br>Conclusion— Our results confirm interobserver variability in mRS assessment. The heterogeneity across countries is intriguing because it appears not to be related solely to language. These data highlight the need for novel strategies to improve reliability.</br&gt

A Complete Atlas of HI Absorption toward HII Regions in the Southern Galactic Plane Survey (SGPS1)

We present a complete catalog of H I emission and absorption spectrum pairs, toward H II regions, detectable within the boundaries of the Southern Galactic Plane Survey (SGPS I), a total of 252 regions. The catalog is presented in graphical, numerical and summary formats. We demonstrate an application of this new dataset through an investigation of the locus of the Near 3kpc Arm.Comment: Accepted for publication by ApJS Feb 6, 2014. Data files and Figure Set (252 images) to appear in the on-line version of the journa