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First Case of Systemic Coronavirus Infection in a Domestic Ferret (Mustela putorius furo) in Peru.
A domestic ferret from Lima, Peru, died after ten days of non-specific clinical signs. Based on pathology, immunohistochemistry and molecular analysis, ferret systemic coronavirus (FRSCV)-associated disease was diagnosed for the first time in South America. This report highlights the potential spread of pathogens by the international pet trade
Adjuvants : an essential component of neisseria vaccines
Adjuvants may be classified into delivery systems and immune potentiator or modulator molecules based on their mechanism of action. Neisseria vaccines containing traditional adjuvants such as aluminium salts have existed for long time, but meningitis caused by Neisseria meningitidis serogroups, particularly serogroup B, continues to be a global health problem. Novel strategies have applied in silico and recombinant technologies to develop "universal" antigens (e.g. proteins, peptides and plasmid DNA) for vaccines, but these antigens have been shown to be poorly immunogenic even when alum adjuvanted, implying a need for better vaccine design. In this work we review the use of natural, detoxified, or synthetic molecules in combination with antigens to activate the innate immune system and to modulate the adaptive immune responses. In the main, antigenic and imune potentiator signals are delivered using nano-, micro-particles, alum, or emulsions. The importance of interaction between adjuvants and antigens to activate and target dendritic cells, the bridge between the innate and adaptive immune systems, will be discussed. In addition, nasal vaccine strategies based on the development of mucosal adjuvants and Neisseria derivatives to eliminate the pathogen at the site of infection provide promising adjuvants effective not only against respiratory pathogens, but also against pathogens responsible for enteric and sexually transmitted diseases
Unveiling the Active Nucleus of Centaurus A
We report new HST WFPC2 and NICMOS observations of the center of the nearest
radio galaxy Centaurus A (NGC 5128) and discuss their implications for our
understanding of the active nucleus and jet. We detect the active nucleus in
the near-IR (K and H) and, for the first time, in the optical (I and V),
deriving the spectral energy distribution of the nucleus from the radio to
X-rays. The optical and part of the near-IR emission can be explained by the
extrapolation of the X-ray power law reddened by A_V~14mag, a value consistent
with other independent estimates.
The 20pc-scale nuclear disk discovered by Schreier et al. (1998) is detected
in the [FeII] 1.64mic line and presents a morphology similar to that observed
in Pa alpha with a [FeII]/Pa alpha ratio typical of low ionization Seyfert
galaxies and LINERs. NICMOS 3 Pa alpha observations in a 50"x50" circumnuclear
region suggest enhanced star formation (~0.3Msun/yr) at the edges of the
putative bar seen with ISO, perhaps due to shocks driven into the gas.
The light profile, reconstructed from V, H and K observations, shows that
Centaurus A has a core profile with a resolved break at ~4" and suggests a
black--hole mass of ~10^9 Msun. A linear blue structure aligned with the
radio/X-ray jet may indicate a channel of relatively low reddening in which
dust has been swept away by the jet.Comment: 19 pages, 13 figures, Astrophysical Journal, in press. High quality
figures available at http://www.arcetri.astro.it/~marconi/colpic.htm
A subarcsecond near-infrared view of massive galaxies at z > 1 with Gemini Multiconjugate Adaptive Optics
We present images taken using the Gemini South Adaptive Optics Imager (GSAOI)
with the Gemini Multiconjugate Adaptive Optics System (GeMS) in three 2
arcmin fields in the Spitzer Extragalactic Representative Volume Survey.
These GeMS/GSAOI observations are among the first resolution
data in the near-infrared spanning extragalactic fields exceeding
in size. We use these data to estimate galaxy sizes, obtaining
results similar to those from studies with the Hubble Space Telescope, though
we find a higher fraction of compact star forming galaxies at . To
disentangle the star-forming galaxies from active galactic nuclei (AGN), we use
multiwavelength data from surveys in the optical and infrared, including
far-infrared data from Herschel, as well as new radio continuum data from the
Australia Telescope Compact Array and Very Large Array. We identify
ultraluminous infrared galaxies (ULIRGs) at , which consist of a
combination of pure starburst galaxies and Active Galactic Nuclei
(AGN)/starburst composites. The ULIRGs show signs of recent merger activity,
such as highly disturbed morphologies and include a rare candidate triple AGN.
We find that AGN tend to reside in hosts with smaller scale sizes than purely
star-forming galaxies of similar infrared luminosity. Our observations
demonstrate the potential for MCAO to complement the deeper galaxy surveys to
be made with the James Webb Space Telescope.Comment: 20 pages, AJ, in pres
Magnetic and superconducting instabilities of the Hubbard model at the van Hove filling
We use a novel temperature-flow renormalization group technique to analyze
magnetic and superconducting instabilities in the two-dimensional t-t' Hubbard
model for particle densities close to the van Hove filling as a function of the
next-nearest neighbor hopping t'. In the one-loop flow at the van Hove filling,
the characteristic temperature for the flow to strong coupling is suppressed
drastically around t'_c approx. -0.33t, suggesting a quantum critical point
between d-wave pairing at moderate t'>t'_c and ferromagnetism for t'<t'_c. Upon
increasing the particle density in the latter regime the leading instability
occurs in the triplet pairing channel.Comment: 4 pages, to appear in Physical Review Letter
AINFO - versão 5.0: manual on-line.
O AINFO é um sistema para automação de bibliotecas e recuperação de informação, desenvolvimento em padrão Windows, com arquitetura cliente/servidor baseada no sistema gerenciador de banco de dados relacional Firebird. Pemite o gerenciamento de informação técnico-científica, integrando bases de dados documentais, cadastrais e processos bibliográficos através do armazenamento, atualização, indexação e recuperação de informação de forma simples e rápida, utilizando não apenas recursos de um istema gerenciador de banco de dados, como controle de concorrência e manutenção de integridade das bases de dados, mas também oferecendo facilidades de recuperação de informação textual não disponíveis nesses sistemas.bitstream/CNPTIA/10207/1/doc40.pdfAcesso em: 29 maio 2008
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