2 research outputs found
Energy Transfer in Microhydrated Uracil, 5‑Fluorouracil, and 5‑Bromouracil
Experiment
and theory are combined to study the interaction of
low energy electrons with microhydrated uracil and its halogenated
analogues 5-fluorouracil and 5-bromouracil. We report electron ionization
(EI) and electron attachment (EA) mass spectra for the uracils with
different degrees of hydration. Both EI and EA lead to evaporation
of water molecules. The number of evaporated molecules serves as a
measure of the energy transferred to the solvent. Upon EI, the amount
of energy transferred to neighboring water molecules is similar for
all three studied species. On the other hand, the energy transferred
upon EA rises significantly from uracil to 5-fluorouracil and 5-bromouracil.
5-Bromouracil is the only studied molecule that undergoes dissociative
electron attachment after hydration at the studied energy of 1.2 eV.
Theoretical modeling of the energetics for the electron attachment
process allows for setting the energy transferred to the solvent on
the absolute scale. We discuss the importance of this energy for the
radiosensitization