Synthesis, Characterization and Pharmacological Activities of 3,6-Disubstituted-1,2,4-triazolo [3,4-b]- 1,3,4-thiadiazoles and their Dihydro Analogues

Abstract: 4-Amino-5-aryl/heteroaryl substituted-3-mercapto-1,2,4-triazoles 3(a-d) were prepared from the corresponding aromatic carboxylic acids through a multi-step sequence. Compounds 3(a-d) were made to react with various aromatic/hetero aromatic acids and hetero aromatic aldehydes to give 3,6-disubstituted-1,2,4-triazolo [3,4-b]-1,3,4-thiadizoles and 3,6-disubstituted-5,6-dihydro-1,2,4-triazolo [3,4-b]-1,3,4-thiadizoles respectively. Elemental analysis, IR, 1 H NMR and mass spectral data elucidated the structures of all newly synthesized compounds. Synthesized compounds are studied for their antibacterial, antifungal, anti-inflammatory and analgesic activities. Some of the tested compounds showed significant pharmacological activities

Self-assembled molecular films of tetraamino metal (Co, Cu, Fe) phthalocyanines on gold and silver: electrochemical and spectroscopic characterization

The formation of molecular films of 2,9,16,23-tetraamino metal phthalocyanines [TAM(II)Pc; M (II) = Co, Cu, and TAM(III)Pc; M = Fe] by spontaneous adsorption on gold and silver surfaces is described. The properties of these films have been investigated by cyclic voltammetry, impedance, and FT-Raman spectroscopy. The charge associated with Co(II) and Co(I) redox couple in voltammetric data leads to a coverage of (0.35 ± 0.05) × 10-10 mol cm<SUP>-2</SUP>, suggesting that the tetraamino cobalt phthalocyanine is adsorbed as a monolayer with an almost complete coverage. The blocking behavior of the films toward oxygen and Fe(CN)<SUB>6</SUB> <SUP>3-/4-</SUP> redox couple have been followed by cyclic voltammetry and impedance measurements. This leads to an estimate of the coverage of about 85 % in the case of copper and the iron analogs. FT-Raman studies show characteristic bands around 236 cm<SUP>-1</SUP> revealing the interaction between the metal substrate and the nitrogen of the -NH<SUB>2</SUB> group on the phthalocyanine molecules

Synthesis and biological activities of Bis alkyl 1,3,4-oxadiazole incorporated azo dye derivatives

3,5-Bis(alkyl-1,3,4-oxadiazole-2-yl azo dyes were synthesized by a multi-step reaction sequence. Structures of newly synthesized compounds were characterized and confirmed by IR, NMR, and Mass spectral studies. The synthesized compounds were screened for their antimicrobial and in vitro antioxidant properties. The results of this investigation revealed that the newly synthesized compounds are potent antibacterial and antioxidant agents. All the synthesized compounds exhibit significant biological activity and certainly hold a greater promise for discovering potent biologically active molecules

Self-assembled molecular films of tetraamino metal (Co, Cu, Fe) phthalocyanines on gold and silver. Electrochemical and spectroscopic characterization

The formation of molecular films of 2,9,16,23-tetraamino metal phthalocyanines [TAM(II)Pc; M (II) = Co, Cu, and TAM(III)Pc; M = Fe] by spontaneous adsorption on gold and silver surfaces is described. The properties of these films have been investigated by cyclic voltammetry, impedance, and FT-Raman spectroscopy. The charge associated with Co(II) and Co(I) redox couple in voltammetric data leads to a coverage of (0.35+/-0.05) x 10(-10) mol cm(-2), suggesting that the tetraamino cobalt phthalocyanine is adsorbed as a monolayer with an almost complete coverage. The blocking behavior of the films toward oxygen and Fe(CN)(6)(3-/4-) redox couple have been followed by cyclic voltammetry and impedance measurements. This leads to an estimate of the coverage of about 85 % in the case of copper and the iron analogs. FT-Raman studies show characteristic bands around 236 cm(-1) revealing the interaction between the metal substrate and the nitrogen of the -NH2 group on the phthalocyanine molecules

Synthesis, characterization and electrochemical investigations of azo dyes derived from 2-amino-6-ethoxybenzothiazole

In this paper, we reported the three novel heterocyclic azo dyes prepared by the diazotization method using 2-amino-6-ethoxybenzothiazole with three different coupling compounds under suitable optimized experimental conditions. Structural features of the title compounds have been accomplished by the various analytical techniques like UV–Visible absorption spectra, FT-IR, NMR (1H and 13C), elemental analysis and mass spectrometry. Also, solvatochromism of the prepared azo dyes was studied at different solvents with increasing polarity. Further, the electrochemical properties of the synthesized compounds were investigated by using cyclic voltammetric technique. The effects of sulphuric acid and scan rate are also studied at glassy carbon electrode. The overall reaction is diffusion controlled and tentative electrode reaction mechanism was proposed. © 201

Viscosity, ultrasonic, and refractometric studies of chitosan/polyethylene glycol blend in solution at 30, 40, and 50°C

Measurements of viscosity, ultrasonic velocity, refractive index, and density of chitosan (CS)/polyethylene glycol (PEG) blends in buffer solution (0.1 M acetic acid+0.2 M sodium acetate) were carried out for different blend compositions at 30, 40, and 50 degrees C. Using the viscosity data, interaction parameters mu and alpha were computed to determine miscibility. These values revealed that the blend was miscible when the chitosan content was more than 60% of the blend. The results were further confirmed by ultrasonic velocity, density, and refractive index measurements. Further, the results revealed that the change in temperature has no significant effect on the miscibility of CS/PEG polymer blends

Studies on the miscibility of chitosan/poly(vinyl pyrrolidone) blend in solution by viscometry, ultrasonic velocity, density and refractometry techniques at 30, 40, and 50°c

Polymer blends of chitosan (CHI) with poly(vinyl pyrrolidone) (PVP) have been prepared by solution blending, and their miscibility studies were carried out by using physical techniques over an extended range of concentration and composition in buffer solution. The viscosity, ultrasonic velocity, density, and refractive index were measured at 30, 40, and 50°C, respectively. Using viscosity data, the interaction parameter μ and α were computed to probe the miscibility. These values revealed that the blend is miscible when the chitosan content is more than 60% in the blend at all temperatures. The obtained results were further confirmed by the ultrasonic velocity, density, and refractive index measurements

Synthesis, Characterization and Pharmacological Activities of 3,6-Disubstituted-1,2,4-triazolo [3,4-b]-1,3,4-thiadiazoles and their Dihydro Analogues

4-Amino-5-aryl/heteroaryl substituted-3-mercapto-1,2,4-triazoles 3(a-d) were prepared from the corresponding aromatic carboxylic acids through a multi-step sequence. Compounds 3(a-d) were made to react with various aromatic/hetero aromatic acids and hetero aromatic aldehydes to give 3,6-disubstituted-1,2,4-triazolo [3,4-b]-1,3,4-thiadizoles and 3,6-disubstituted-5,6-dihydro-1,2,4-triazolo [3,4-b]-1,3,4-thiadizoles respectively. Elemental analysis, IR, 1H NMR and mass spectral data elucidated the structures of all newly synthesized compounds. Synthesized compounds are studied for their antibacterial, antifungal, anti-inflammatory and analgesic activities. Some of the tested compounds showed significant pharmacological activities

Miscibility studies on chitosan/poly(vinyl alcohol) blends

Miscibility studies of chitosan (CHI)/poly(vinyl alcohol) (PVA) blend in buffer solution were carried out in several blend compositions (10/90, 20/80, … , 90/10). Viscosity, ultrasonic velocity, density and refractive were measured at 30, 40 and 50°C, respectively. Using viscosity data, the interaction parameters μ and thermodynamic parameter α were computed to determine the miscibility of the blend in solution. These values revealed that the blend is miscible when the chitosan content is more than 60% in the blend. The obtained results were further confirmed by the ultrasonic velocity, density and refractive index study