Corporate Diseases of Excellence

Corporations, like people, develop various afflictions during their evolution. Sometimes these ailments are from outdated habits; sometimes they are caused by frailties; sometimes they are just the product of youth or age; and occasionally they result from tremendous exertions of energy in the pursuit of being the best, which are followed by eventual breakdowns. This article will examine what we consider to be the top 5 corporate diseases of excellence—those management maladies which prevent the majority of U.S. corporations from being great and stop the successful corporations from being even better. The common thread running through all 5 afflictions is loss of commitment, leading to a loss of profits

Participative Management: Selective Means Effective

Participative management has been a hot topic of debate for decades. intuitively, if workers are allowed to take part in decision that affect their work lives they should be happier and, therefore, more productive. While this hypothesis is attractive, especially to caring managers and writers, the effective use of PM has proven to be much more complicated than originally anticipated. What is PM? What costs are associated with PM? What benefits does PM produce? When can PM be used most effectively? To date, management experts and practitioners have agreed to disagree regarding PM. Conflicting and ambiguous studies and experiences abound. In view of the recently uncovered complexity and resulting confusion surrounding the use of PM, this article will attempt to clarify the relevant concepts and direct us toward an effective, selective approach

Genomic Classification of Cutaneous Melanoma

We describe the landscape of genomic alterations in cutaneous melanomas through DNA, RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 patients. We establish a framework for genomic classification into one of four sub-types based on the pattern of the most prevalent significantly mutated genes: mutant BRAF, mutant RAS, mutant NF1, and Triple-WT (wild-type). Integrative analysis reveals enrichment of KIT mutations and focal amplifications and complex structural rearrangements as a feature of the Triple-WT subtype. We found no significant outcome correlation with genomic classification, but samples assigned a transcriptomic subclass enriched for immune gene expression associated with lymphocyte infiltrate on pathology review and high LCK protein expression, a T cell marker, were associated with improved patient survival. This clinicopathological and multidimensional analysis suggests that the prognosis of melanoma patients with regional metastases is influenced by tumor stroma immunobiology, offering insights to further personalize therapeutic decision-makingclose3