Additional file 1: of Association between changes in brain microstructure and cognition in older subjects at increased risk for vascular disease

List of the individual ethics committees that gave approval for the Prospective Study of Pravastatin in the Elderly at Risk study. (DOCX 13 kb

Additional file 1: of Renal function estimation and Cockcroft–Gault formulas for predicting cardiovascular mortality in population-based, cardiovascular risk, heart failure and post-myocardial infarction cohorts: The Heart ‘OMics’ in AGEing (HOMAGE) and the high-risk myocardial infarction database initiatives

Supplemental Material. Table S1. Linearity tests for each formula using restricted cubic splines with 3 knots. Table S2. Cox-regression models according to the different formulas (categorized for “renal function” stages) and age subgroups. Table S3. Improvement indices for glomerular filtration rate estimation formulas in comparison to body surface area. Figure S1. Association between “renal function” formulas and cardiovascular mortality in each population setting using restricted cubic splines with y-axis in log scale. Figure S2. Calibration assessment for “renal function” formulas within each population. (DOCX 883 kb

Additional file 7: of Blood lipids influence DNA methylation in circulating cells

The HDL-C PS is nominally associated with confounder neutrophil counts. (CSV 202 bytes

Additional file 9: of Blood lipids influence DNA methylation in circulating cells

Comparison between EWAS and MR estimates (with 95 % confidence intervals). (PDF 109 kb

Additional file 3: of Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

Video S1. (Quicktime) Video to illustrate the DORV phenotype finding in an Adamts6 mutant heart. (MOV 1983 kb

Additional file 2: of Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

Figure S1. Manhattan plot for European and African-American ancestry single variant analysis. Figure S2. Quantile-quantile plot for European and African-American ancestry single variant analysis. Figure S3. Manhattan plot for EA single variant analysis. Figure S4. QQ plot for EA single variant analysis. Figure S5. Manhattan plot for AA single variant analysis. Figure S6. Quantile-quantile plot for AA single variant analysis. Figure S7. Miami plot European and African-American ancestry sex-stratified single variant analysis. Figure S8. Quantile-quantile plots for European and African-American ancestry sex-stratified single variant analyses. Figure S9. Normal morphology of adult Adamts6 heterozygous hearts. (DOCX 4290 kb