A Role of the Bile Salt Receptor FXR in Atherosclerosis

This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism. At the molecular level, bile salts regulate lipid and energy homeostasis mainly via the bile salt receptors FXR and TGR5. Activation of FXR has been shown to improve plasma lipid profiles, whereas Fxr(-/-) mice have increased plasma triglyceride and very-low-density lipoprotein levels. Nevertheless, high-density lipoprotein cholesterol levels are increased in these mice, suggesting that FXR has both anti-and proatherosclerotic properties. Interestingly, there is increasing evidence for a role of FXR in "nonclassical" bile salt target tissues, eg, vasculature and macrophages. In these tissues, FXR has been shown to influence vascular tension and regulate the unloading of cholesterol from foam cells, respectively. Recent publications have provided insight into the antiinflammatory properties of FXR in atherosclerosis. Bile salt signaling via TGR5 might regulate energy homeostasis, which could serve as an attractive target to increase energy expenditure and weight loss. Interventions aiming to increase cholesterol turnover (eg, by bile salt sequestration) significantly improve plasma lipid profiles and diminish atherosclerosis in animal models. Bile salt metabolism and bile salt signaling pathways represent attractive therapeutic targets for the treatment of atherosclerosi

Effects of nonnormality on studies of morphological variation of a Rhabdomesine bryozoan, Streblotrypa (Streblascopora) prisca (Gabb and Horn)

13 p., 4 fig.http://paleo.ku.edu/contributions.htm

Theatre for Social Change: Histories & Applications

Theater is not only an art form, but also a method of communication and community-building. My research investigates how theater can be used to create social change. I study approaches to using theater as a vehicle for social change and a tool to communicate diverse perspectives and cultivate empathy. My work focuses on a history of theater for social change, examples of theater for social change including plays and performance pieces, and ways of both creating and teaching theater for social change. My project culminates in an annotated bibliography, a research paper, an original theater for social change monologue, and a syllabus for a college-level theatre for social change course

Viscous Decoupling Transitions for Individually Dragged Particles in Systems with Quenched Disorder

We show that when an individual particle is dragged through an assembly of other particles in the presence of quenched disorder, a viscous decoupling transition occurs between the dragged particle and the surrounding particles which is controlled by the quenched disorder. A counterintuitive consequence of this transition is that the velocity of the dragged particle can be increased by increasing the strength or density of the quenched disorder. The decoupling transition can also occur when the external drive on the dragged particle is increased, and is observable as a clear signature in the velocity-force response.Comment: 4 pages, 3 postscript figure

Influence of Adjuvants on Pesticide Soil-Air Partition Coefficients: Laboratory Measurements and Predicted Effects on Volatilization

A solid-phase fugacity meter was used to measure the soil–air partition coefficients of three semivolatile pesticides (chlorpyrifos, pyrimethanil, and trifluralin) in the absence of additional adjuvants (Ksoil–air,AI), as part of commercial formulations (Ksoil–air,formulation), and as formulation mixtures with an additional spray adjuvant added (Ksoil–air,formulation+spray adjuvant). Chlorpyrifos Ksoil–air,formulation values were also measured over 15–30 °C, allowing for the change in internal energy of the phase transfer reaction (Δsoil–airU) to be calculated and compared to the Δsoil–airU for Ksoil–air,AI from the literature. Measured Ksoil–air values were then used as input parameters in a pesticide volatilization model to understand how their variability affects pesticide volatilization rates under different conditions. Initial experiments conducted at ∼24 °C indicated that all pesticides volatilized more readily in the presence of adjuvants than in their absence and that the additional spray adjuvant had minimal impact. The Δsoil–airU values were 328 and 90 kJ/mol for chlorpyrifos in the absence and presence of formulation adjuvants, respectively, suggesting that adjuvants may weaken or disrupt intermolecular attractions between pesticide molecules and soil. At temperatures below 24.5 °C, modeled chlorpyrifos volatilization rates were higher in the presence of adjuvants than in their absence; however, the opposite occurred at temperatures above 24.5 °C

An Integrated Assessment of Archaeobotanical Recovery Methods in the Neotropical Rainforest of Northern Belize: Flotation and Dry Screening

This report presents results of a study examining the ancient use of plants at four Late Classic (CE 600-900) Maya rural farmsteads in northwestern Belize. Our research specifically targeted residential middens for macrobotanical recovery. Samples yielded the remains of more than a dozen plant families, representing some genera that do not currently grow in the area. These plants were used in the Late Classic, countering the idea that ancient botanical remains do not survive in Neotropical archaeological contexts. We also evaluated two macrobotanical sample processing methods vis-à-vis one another: flotation and dry screening. Our results indicate that flotation recovered 58% more seeds than dry screening, while dry screening yielded almost twice as much charcoal and other wood as flotation. The divergent quantities in the types of material recovered suggest a comprehensive macrobotanical recovery program should include the use of both processing methods

Paediatric admissions to hospitals in the Cape Town Metro district: A survey

A point prevalence survey of 381 paediatric medical inpatients in the 11 public hospitals in Cape Town in November 2007 showed that 70% of them were in central hospitals, with 39.4% requiring level 3 (sub-specialist) care. Numbers of children in hospital and their levels of health care requirement did not vary by sub-district of residence. Seventy-seven per cent of patients were under 5 years of age; 5% were teenagers. Few patients changed level of care during admission, but 10% did not need to be in hospital at the time of review. Median length of stay was 4 days, with children with level 3 needs having the longest lengths of stay. An under-provision of level 1 beds was demonstrated. HIV infection had been identified in 12% of admissions. While children with level 3 problems were well catered for in terms of bed provision, level 1 and step-down/home care provision were deficient or inefficiently utilised