AMBER and CRIRES observations of the binary sgB[e] star HD 327083: evidence of a gaseous disc traced by CO bandhead emission

HD 327083 is a sgB[e] star that forms a binary system with an orbital semi-major axis of ~1.7 AU. Our previous observations using the VLTI and AMBER in the medium resolution K-band mode spatially resolved the environment of HD 327083. The continuum visibilities obtained indicate the presence of a circumbinary disc. CO bandhead emission was also observed. However, due to the limited spectral resolution of the previous observations, the kinematic structure of the emitting material was not constrained. In this paper, we address this and probe the source of the CO emission with high spectral resolution and spatial precision. We have observed HD 327083 with high spectral resolution (25 & 6 km/s) using AMBER and CRIRES. The observations are compared to kinematical models to constrain the source of the emission. It is shown that the CO bandhead emission can be reproduced using a model of a Keplerian disc with an inclination and size consistent with our previous VLTI observations. The model is compared to AMBER differential phase measurements, which have a precision as high as 30-micro-arcseconds. A differential phase signal corresponding to 0.15 milli-arcseconds (~5 sigma) is seen over the bandhead emission, which is in excellent agreement with the model that fits the CRIRES observations. In comparison, a model of an equatorial outflow, as envisaged in the standard sgB[e] scenario, does not reproduce the observations well. The excellent agreement between the disc model and observations in the spatial and spectral domains is compelling evidence that the CO bandhead emission of HD 327083 originates in a circumbinary Keplerian disc. In contrast, the model of an equatorial outflow cannot reproduce the observations well. This suggests that the standard sgB[e] scenario is not applicable to HD 327083, which supports the hypothesis that the B[e] behaviour of HD 327083 is due to binarity (ABRIDGED).Comment: Accepted for publication in A&

M Theory As A Matrix Model: A Conjecture

We suggest and motivate a precise equivalence between uncompactified eleven dimensional M-theory and the N = infinity limit of the supersymmetric matrix quantum mechanics describing D0-branes. The evidence for the conjecture consists of several correspondences between the two theories. As a consequence of supersymmetry the simple matrix model is rich enough to describe the properties of the entire Fock space of massless well separated particles of the supergravity theory. In one particular kinematic situation the leading large distance interaction of these particles is exactly described by supergravity . The model appears to be a nonperturbative realization of the holographic principle. The membrane states required by M-theory are contained as excitations of the matrix model. The membrane world volume is a noncommutative geometry embedded in a noncommutative spacetime.Comment: Typo and tex error corrected. 41 pages, harvma

Probing discs around massive young stellar objects with CO first overtone emission

We present high resolution (R~50,000) spectroastrometry over the CO 1st overtone bandhead of a sample of seven intermediate/massive young stellar objects. These are primarily drawn from the red MSX source (RMS) survey, a systematic search for young massive stars which has returned a large, well selected sample of such objects. The mean luminosity of the sample is approximately 5 times 10^4 L_\odot, indicating the objects typically have a mass of ~15 solar masses. We fit the observed bandhead profiles with a model of a circumstellar disc, and find good agreement between the models and observations for all but one object. We compare the high angular precision (0.2-0.8 mas) spectroastrometric data to the spatial distribution of the emitting material in the best-fitting models. No spatial signatures of discs are detected, which is entirely consistent with the properties of the best-fitting models. Therefore, the observations suggest that the CO bandhead emission of massive young stellar objects originates in small-scale disks, in agreement with previous work. This provides further evidence that massive stars form via disc accretion, as suggested by recent simulations.Comment: Accepted for publication in MNRA

VLTI/AMBER observations of the binary B[e] supergiant HD 327083

HD 327083 is a luminous B type star which exhibits emission lines and an infrared excess and is therefore classified as a supergiant B[e] star. In addition, the star is the primary of a close binary system. It is not clear whether the B[e] behaviour of HD 327083 is related to its binarity or its evolutionary state. Here we address this issue by studying its circumstellar environment with high spatial resolution. To this end, we have observed HD 327083 with the VLTI and AMBER in the medium resolution K-band setting. 13CO bandhead emission is detected, confirming HD 327083 is a post-main sequence object. The observations spatially resolve the source of the NIR continuum and the Br-gamma and CO line emission. In addition, differential phase measurements allow us to probe the origin of the observed Br-gamma emission with sub-mas precision. Using geometrical models, we find that the visibilities and closure phases suggest that the close binary system is surrounded by a circum-binary disk. We also find that in the case of the binary HD 327083, the relative sizes of the continuum and Br-gamma emitting regions are different to those of a single supergiant B[e] star where the standard dual outflow scenario is thought to apply. These findings are consistent with the hypothesis that the mass loss of HD 327083 is related to its binary nature.Comment: Accepted in A&

Docetaxel (Taxotere): an active agent in metastatic urothelial cancer; results of a phase II study in non-chemotherapy-pretreated patients.

The semisynthetic taxoid docetaxel was investigated in a phase II study in non-chemotherapy pretreated patients with metastatic urothelial cell cancer. Thirty patients (median age 61, range 45-72) were treated with docetaxel 100 mg m(-2) administered as a 1-h infusion every 3 weeks. Of 29 evaluable patients, four achieved a complete response and five a partial response, for an overall response rate of 31%. The median duration of response was 6 months (range 4-51+). A total of 104 cycles were administered. The median number of cycles given was three (range 1-9). Toxic effects of docetaxel mainly consisted of neutropenia, which, however, rarely caused infectious complications (5%). Fluid retention or neuropathy necessitated treatment cessation in two patients. We conclude that docetaxel is an effective agent in urothelial cell cancer, and should be further tested in combination chemotherapy

A mid-IR interferometric survey with MIDI/VLTI: resolving the second-generation protoplanetary disks around post-AGB binaries

We present a mid-IR interferometric survey of the circumstellar environment of a specific class of post-Asymptotic Giant Branch (post-AGB) binaries. For this class the presence of a compact dusty disk has been postulated on the basis of various spatially unresolved measurements. Our interferometric survey was performed with the MIDI instrument on the VLTI. In total 19 different systems were observed using variable baseline configurations. Combining all the visibilities at a single wavelength at 10.7 micron, we fitted two parametric models to the data: a uniform disk (UD) and a ring model mimicking a temperature gradient. We compared our observables of the whole sample, with synthetic data computed from a grid of radiative transfer models of passively irradiated disks in hydrostatic equilibrium. These models are computed with a Monte Carlo code that has been widely applied to describe the structure of protoplanetary disks around young stellar objects (YSO). The spatially resolved observations show that the majority of our targets cluster closely together in the distance-independent size-colour diagram, and have extremely compact N-band emission regions. The typical uniform disk diameter of the N-band emission region is about 40 mass which corresponds to a typical brightness temperature of 400-600~K. The resolved objects display very similar characteristics in the interferometric observables and in the spectral energy distributions. Therefore, the physical properties of the disks around our targets must be similar. The grid of protoplanetary disk models covers very well the observed objects. Much like for young stars, the spatially resolved N-band emission region is determined by the hot inner rim of the disk. Continued comparisons between post-AGB and protoplanetary disks will help to understand grain growth and disk evolution processes,Comment: 30 pages, 21 figures, in press in Astronomy and Astrophysic