Facilitation of opiate-and enkephalin-induced motor activity in the mouse by phenytoin sodium and carbamazepine

In the first experiment, adult male Swiss-Webster mice were systemically injected with a standard dose of morphine. Compared to the influence of vehicle, the motor activity of morphine-injected mice was increased. Neither phenytoin sodium nor carbamazepine alone facilitated motor activity, but pretreatment with both drugs further facilitated the increased motor activity produced by morphine. In a second experiment, mice were injected centrally with a long-acting analog of leu-enkephalin. It also increased motor activity in comparison with vehicle. Again, both phenytoin sodium and carbamazepine further facilitated this response. Both experiments suggest a facilitatory interaction between some aspects of these anticonvulsants and opiate-induced motor activity.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46410/1/213_2004_Article_BF00491980.pd

Valor prognostico dos teores de potassio e sodio no liquido cefalorraquiano e no sangue de doentes em coma: estudo de 55 casos

Trata-se de um estudo prospective) com 55 doentes, tomados ao acaso, independentemente da idade, sexo, grau de coma ou da sua etiologia. Foi medida a concentração do potássio e do sódio no LCR e no soro sangüíneo destes doentes, visando a um critério auxiliar de avaliação prognostica. Os resultados mostraram que as taxas elevadas de potássio no LCR são indicativo de mau prognóstico. No texto são abordados os aspectos fisiopatológicos dos achados