19 research outputs found
Giant cell tumor of bone revisited
Giant cell tumor (GCT) of bone is a locally aggressive benign neoplasm that is associated with a large biological spectrum ranging from latent benign to highly recurrent and occasionally metastatic malignant bone tumor. It accounts for 4–10% of all bone tumors and typically affects the meta-epiphyseal region of long bones of young adults. The most common site involved is the distal femur, followed by the distal radius, sacrum, and proximal humerus. Clinical symptoms are nonspecific and may include local pain, swelling, and limited range of motion of the adjacent joint. Radiographs and contrast-enhanced magnetic resonance imaging (MRI) are the imaging modalities of choice for diagnosis. Surgical treatment with curettage is the optimal treatment for local tumor control. A favorable clinical outcome is expected when the tumor is excised to tumor-free margins, however, for periarticular lesions this is usually accompanied with a suboptimal functional outcome. Local adjuvants have been used for improved curettage, in addition to systematic agents such as denosumab, bisphosphonates, or interferon alpha. This article aims to discuss the clinicopathological features, diagnosis, and treatments for GCT of bone
Giant cell tumor of bone revisited
Giant cell tumor (GCT) of bone is a locally aggressive benign neoplasm
that is associated with a large biological spectrum ranging from latent
benign to highly recurrent and occasionally metastatic malignant bone
tumor. It accounts for 4-10% of all bone tumors and typically affects
the meta-epiphyseal region of long bones of young adults. The most
common site involved is the distal femur, followed by the distal radius,
sacrum, and proximal humerus. Clinical symptoms are nonspecific and may
include local pain, swelling, and limited range of motion of the
adjacent joint. Radiographs and contrast-enhanced magnetic resonance
imaging (MRI) are the imaging modalities of choice for diagnosis.
Surgical treatment with curettage is the optimal treatment for local
tumor control. A favorable clinical outcome is expected when the tumor
is excised to tumor-free margins, however, for periarticular lesions
this is usually accompanied with a suboptimal functional outcome. Local
adjuvants have been used for improved curettage, in addition to
systematic agents such as denosumab, bisphosphonates, or interferon
alpha. This article aims to discuss the clinicopathological features,
diagnosis, and treatments for GCT of bone
Rib Hump Deformity Correction in Patients with Adolescent Idiopathic Scoliosis: A Comparison of Three Spinal Fusion Systems.
The aim of the present study is to control the hypothesis that the rib hump deformity can be adequately corrected when applying vertebral derotation. We retrospectively studied patients treated with full pedicle screw systems (group A), hybrid constructs (group B), and Harrington rod instrumentation (group C). No costoplasties were performed in the patients included in our study. Derotation was applied in groups A and B. The rib hump deformity was assessed on lateral radiographic studies by rib index (RI). Of the 72 patients that were finally included in our study, 30 patients (24 females and 6 males; mean age, 14.5 ± 2.2 years) were treated with a full pedicle screw system, 23 patients (19 females and 4 males; mean age, 13.8 ± 1.9 years) were treated with a hybrid construct, and 19 patients (16 females and 3 males; mean age, 14.3 ± 2 years) received the Harrington rod instrumentation. In all groups RI was significantly corrected after surgery. Before surgery no difference in RI was found among groups; however, after surgery RI was found significantly higher in group C as compared to groups A and B. The between-group analysis revealed that the correction of RI, and thereby the rib hump deformity correction, did not significantly differ among the three patient groups. In conclusion, it cannot be suggested based on the present study that vertebral derotation alone can offer an adequate correction of the rib hump deformity. Further, the development of rib cage deformity and its degree of interdependence with the scoliotic spinal deformity has to be further investigated and assessed, as it seems that it may not necessarily result directly from the primary vertebral deformity
Aggressive Chordomas: Clinical Outcome of 13 Patients
The authors reviewed the files of all patients with chordomas who were
admitted and treated at their institutions from 1975 to 2012. Patients
were categorized by early local recurrence and metastasis. Aggressive
clinical behavior was defined as local recurrence and metastasis within
24 months of diagnosis and adequate treatment (wide en bloc resection
with microscopically negative tumor margins). According to these
criteria, 13 patients (14.3%) had aggressive chordomas, including 7 men
and 6 women, with mean age of 54 years (range, 37-65 years) at diagnosis
and treatment. All patients had preoperative tumor biopsy, followed by
resection with partial (7 patients) or total sacrectomy (6 patients). In
all cases, biopsy and histologic analysis of resected tumor specimens
showed conventional chordomas. Resection margins were wide (grossly
negative) in 6 patients and wide contaminated in 7 patients. Mean
maximum tumor diameter was 11.8 cm (range, 5-21 cm). Mean follow-up was
43 months (range, 8-131 months). Rates of local recurrence, metastasis,
and death were evaluated. At the last follow-up, all patients had local
recurrence at a mean of 13 months (range, 5-22 months). Histologic
examination of recurrent tumors showed a dedifferentiated chordoma with
a fibrosarcoma component in 2 patients and no histologic change in the
remaining patients. In addition, 8 patients had metastases at a mean of
13 months (range, 4-24 months) and died of their disease. All histologic
findings of metastatic lesions were similar to those of primary tumors.
Early diagnosis of aggressive tumors requires close follow-up of
patients with chordomas. Metastasis is common, with resultant poor
survival
Intercalary reconstructions after bone tumor resections: a review of treatments
An intercalary reconstruction is defined as replacement of the diaphyseal portion of a long bone after segmental skeletal resection (diaphysectomy). Intercalary reconstructions typically result in superior function compared to other limb-sparing procedures as the patient's native joints above and below the reconstruction are left undisturbed. The most popular reconstructive options after segmental resection of a bone sarcoma include allografts, vascularized fibula graft, combined allograft and vascularized fibula, segmental endoprostheses, extracorporeal devitalized autograft, and segmental transport using the principles of distraction osteogenesis. This article aims to review the indications, techniques, limitations, pros and cons, and complications of the aforementioned methods of intercalary bone tumor resections and reconstructions in the context of the ever-growing, brave new field of limb-salvage surgery
Aggressive Chordomas: Clinical Outcome of 13 Patients
none11siThe authors reviewed the files of all patients with chordomas who were admitted and treated at their institutions from 1975 to 2012. Patients were categorized by early local recurrence and metastasis. Aggressive clinical behavior was defined as local recurrence and metastasis within 24 months of diagnosis and adequate treatment (wide en bloc resection with microscopically negative tumor margins). According to these criteria, 13 patients (14.3%) had aggressive chordomas, including 7 men and 6 women, with mean age of 54 years (range, 37-65 years) at diagnosis and treatment. All patients had preoperative tumor biopsy, followed by resection with partial (7 patients) or total sacrectomy (6 patients). In all cases, biopsy and histologic analysis of resected tumor specimens showed conventional chordomas. Resection margins were wide (grossly negative) in 6 patients and wide contaminated in 7 patients. Mean maximum tumor diameter was 11.8 cm (range, 5-21 cm). Mean follow-up was 43 months (range, 8-131 months). Rates of local recurrence, metastasis, and death were evaluated. At the last follow-up, all patients had local recurrence at a mean of 13 months (range, 5-22 months). Histologic examination of recurrent tumors showed a dedifferentiated chordoma with a fibrosarcoma component in 2 patients and no histologic change in the remaining patients. In addition, 8 patients had metastases at a mean of 13 months (range, 4-24 months) and died of their disease. All histologic findings of metastatic lesions were similar to those of primary tumors. Early diagnosis of aggressive tumors requires close follow-up of patients with chordomas. Metastasis is common, with resultant poor survival. [Orthopedics. 201x; xx(x):xxx-xxx.].noneMavrogenis, Andreas F; Angelini, Andrea; Panagopoulos, Georgios N; Pala, Elisa; Calabrò, Teresa; Igoumenou, Vasilios G; Katzouraki, Galatia; Megaloikonomos, Panayiotis D; Pneumaticos, Spyros G; Papagelopoulos, Panayiotis J; Ruggieri, PietroMavrogenis, Andreas F; Angelini, Andrea; Panagopoulos, Georgios N; Pala, Elisa; Calabrò, Teresa; Igoumenou, Vasilios G; Katzouraki, Galatia; Megaloikonomos, Panayiotis D; Pneumaticos, Spyros G; Papagelopoulos, Panayiotis J; Ruggieri, Pietr