1,606 research outputs found
Design and throughput simulations of a hard x-ray split and delay line for the MID station at the European XFEL
This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in AIP Conference Proceedings 1741, 030010 (2016) and may be found at https://doi.org/10.1063/1.4952833.A hard X-ray Split and Delay Line (SDL) under development for the Materials Imaging and Dynamics (MID) station at the European X-Ray Free-Electron Laser (XFEL.EU) is presented. This device will provide pairs of X-ray pulses with a variable time delay ranging from −10 ps to 800 ps in a photon energy range from 5 to 10 keV. Throughput simulations in the SASE case indicate a total transmission of 1.1% or 3.5% depending on the operation mode. In the self-seeded case of XFEL.EU operation simulations indicate that the transmission can be improved to more than 11%.BMBF, 05K13KT4, Verbundprojekt FSP 302 - Freie-Elektronen-Laser: Nanoskopische Systeme. Teilprojekt 1: Split-and-Delay Instrument für die European XFEL Beamline Materials Imaging and Dynamic
The Role of Hypothyroidism in the Etiology and Progression of Dilated Cardiomyopathy in Doberman Pinschers
Background: Hypothyroidism and dilated cardiomyopathy (DCM) are both common diseases in Doberman Pinschers. A possible influence of hypothyroidism on the etiology and progression of DCM is controversial.
Objectives: Evaluation of the role of hypothyroidism in etiology and progression of DCM.
Animals: A total of 175 Doberman Pinschers.
Methods: In this longitudinal prospective study, echocardiography and 24-hour ambulatory ECG recordings were performed in all dogs as screening tests for DCM. Total thyroxine (TT4) and thyroid ultrasonography served as initial screening tests for hypothyroidism and low TT4 values were followed up by a thyroid stimulating hormone (TSH) test or free total thyroxine (fT4)/cTSH measurements. Additionally, a follow-up study of dogs affected by both DCM and hypothyroidism under optimal treatment for hypothyroidism was conducted.
Results: A total of 107 dogs were healthy, 45 dogs had DCM, 11 hypothyroidism, and 12 dogs had both DCM and hypothyroidism. TT4 values as well as the thyroid volumes were equivalent in the healthy dogs and in those with DCM. Neither ventricular premature complexes nor echocardiographic parameters differed between healthy and hypothyroid dogs. Dogs with DCM had a 2.26-fold (CI0.95 = 1.1–4.8) higher risk of also being affected by hypothyroidism. Despite optimal thyroid treatment of dogs with hypothyroidism and DCM, there was a progression of the heart disease.
Conclusions and Clinical Importance: This study did not confirm a role of hypothyroidism in the etiology or progression of DCM. Treatment of hypothyroidism did not improve the clinical outcome
The Role of Hypothyroidism in the Etiology and Progression of Dilated Cardiomyopathy in Doberman Pinschers
Background: Hypothyroidism and dilated cardiomyopathy (DCM) are both common diseases in Doberman Pinschers. A possible influence of hypothyroidism on the etiology and progression of DCM is controversial.
Objectives: Evaluation of the role of hypothyroidism in etiology and progression of DCM.
Animals: A total of 175 Doberman Pinschers.
Methods: In this longitudinal prospective study, echocardiography and 24-hour ambulatory ECG recordings were performed in all dogs as screening tests for DCM. Total thyroxine (TT4) and thyroid ultrasonography served as initial screening tests for hypothyroidism and low TT4 values were followed up by a thyroid stimulating hormone (TSH) test or free total thyroxine (fT4)/cTSH measurements. Additionally, a follow-up study of dogs affected by both DCM and hypothyroidism under optimal treatment for hypothyroidism was conducted.
Results: A total of 107 dogs were healthy, 45 dogs had DCM, 11 hypothyroidism, and 12 dogs had both DCM and hypothyroidism. TT4 values as well as the thyroid volumes were equivalent in the healthy dogs and in those with DCM. Neither ventricular premature complexes nor echocardiographic parameters differed between healthy and hypothyroid dogs. Dogs with DCM had a 2.26-fold (CI0.95 = 1.1–4.8) higher risk of also being affected by hypothyroidism. Despite optimal thyroid treatment of dogs with hypothyroidism and DCM, there was a progression of the heart disease.
Conclusions and Clinical Importance: This study did not confirm a role of hypothyroidism in the etiology or progression of DCM. Treatment of hypothyroidism did not improve the clinical outcome
The Role of Bacteria and Pattern Recognition Receptors in GvHD
Graft-versus-Host Disease (GvHD) is the most serious complication of allogeneic stem cell transplantation (SCT) and results from an activation of donor lymphocytes by recipient antigen-presenting cells (APCs). For a long time, it has been postulated that the intestinal microflora and endotoxin exert a crucial step in this APC activation, as there is early and severe gastrointestinal damage induced by pretransplant conditioning. With the detailed description of pathogen-associated molecular patterns and pathogen recognition receptors single nucleotide polymorphisms of TLRs and especially NOD2 have been identified as potential risk factors of GvHD and transplant related complications thus further supporting the crucial role of innate immunity in SCT, related complications. Gastrointestinal decontamination and neutralization of endotoxin have been used to interfere with this early axis of activation with some success but more specific approaches of modulation of innate immunity are needed for further improvement of clinical outcome
Synthesizing Program Input Grammars
We present an algorithm for synthesizing a context-free grammar encoding the
language of valid program inputs from a set of input examples and blackbox
access to the program. Our algorithm addresses shortcomings of existing grammar
inference algorithms, which both severely overgeneralize and are prohibitively
slow. Our implementation, GLADE, leverages the grammar synthesized by our
algorithm to fuzz test programs with structured inputs. We show that GLADE
substantially increases the incremental coverage on valid inputs compared to
two baseline fuzzers
Splenic pooling and loss of VCAM-1 causes an engraftment defect in patients with myelofibrosis after allogeneic hematopoietic stem cell transplantation
Myelofibrosis is a myeloproliferative neoplasm that results in cytopenia, bone marrow fibrosis and extramedullary hematopoiesis. Allogeneic hematopoietic stem cell transplantation is the only curative treatment but is associated with a risk of delayed engraftment and graft failure. In this study, patients with myelofibrosis (n=31) and acute myeloid leukemia (n=31) were analyzed for time to engraftment, graft failure and engraftment-related factors. Early and late neutrophil engraftment and late thrombocyte engraftment were significantly delayed in patients with myelofibrosis as compared to acute myeloid leukemia, and graft failure only occurred in myelofibrosis (6%). Only spleen size had a significant influence on engraftment efficiency in myelofibrosis patients. To analyze the cause for the engraftment defect, clearance of hematopoietic stem cells from peripheral blood was measured and immunohistological staining of bone marrow sections was performed. Numbers of circulating CD34+ were significantly reduced at early time points in myelofibrosis patients, whereas CD34+CD38- and colony-forming cells showed no significant difference in clearance. Staining of bone marrow sections for homing proteins revealed a loss of VCAM-1 in myelofibrosis with a corresponding significant increase in the level of soluble VCAM-1 within the peripheral blood. In conclusion, our data suggest that reduced engraftment and graft failure in myelofibrosis patients is caused by an early pooling of CD34+ hematopoietic stem cells in the spleen and a bone marrow homing defect caused by the loss of VCAM-1. Improved engraftment in myelofibrosis might be achieved by approaches that reduce spleen size and cleavage of VCAM-1 in these patients prior to hematopoietic stem cell transplantation
C-Band All-Sky Survey: A First Look at the Galaxy
We present an analysis of the diffuse emission at 5 GHz in the first quadrant
of the Galactic plane using two months of preliminary intensity data taken with
the C-Band All Sky Survey (C-BASS) northern instrument at the Owens Valley
Radio Observatory, California. Combining C-BASS maps with ancillary data to
make temperature-temperature plots we find synchrotron spectral indices of
between 0.408 GHz and 5 GHz and between 1.420 GHz and 5 GHz for ,
. Through the subtraction of a radio recombination
line (RRL) free-free template we determine the synchrotron spectral index in
the Galactic plane () to be between
0.408 GHz and 5 GHz, with a contribution of per cent from free-free
emission at 5\,GHz. These results are consistent with previous low frequency
measurements in the Galactic plane. By including C-BASS data in spectral fits
we demonstrate the presence of anomalous microwave emission (AME) associated
with the HII complexes W43, W44 and W47 near 30 GHz, at 4.4 sigma, 3.1 sigma
and 2.5 sigma respectively. The CORNISH VLA 5 GHz source catalogue rules out
the possibility that the excess emission detected around 30\;GHz may be due to
ultra-compact HII regions. Diffuse AME was also identified at a 4 sigma level
within , between 5
GHz and 22.8 GHz.Comment: 16 pages, 9 figures, submitted to MNRAS, referee's corrections made,
awaiting for final approval for publicatio
The C-Band All-Sky Survey: Instrument design, status, and first-look data
The C-Band All-Sky Survey (C-BASS) aims to produce sensitive, all-sky maps of
diffuse Galactic emission at 5 GHz in total intensity and linear polarization.
These maps will be used (with other surveys) to separate the several
astrophysical components contributing to microwave emission, and in particular
will allow an accurate map of synchrotron emission to be produced for the
subtraction of foregrounds from measurements of the polarized Cosmic Microwave
Background. We describe the design of the analog instrument, the optics of our
6.1 m dish at the Owens Valley Radio Observatory, the status of observations,
and first-look data.Comment: 10 pages, 11 figures, published in Proceedings of SPIE MIllimeter,
Submillimeter, and Far-Infrared Detectors and Instrumentation for Astronomy V
(2010), Vol. 7741, 77411I-1 - 77411I-1
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