Small radii of neutron stars as an indication of novel in-medium effects

At present, neutron star radii from both observations and model predictions remain very uncertain. Whereas different models can predict a wide range of neutron star radii, it is not possible for most models to predict radii that are smaller than about 10 km, thus if such small radii are established in the future they will be very difficult to reconcile with model estimates. By invoking a new term in the equation of state that enhances the energy density, but leaves the pressure unchanged we simulate the current uncertainty in the neutron star radii. This new term can be possibly due to the exchange of the weakly interacting light U-boson with appropriate in-medium parameters, which does not compromise the success of the conventional nuclear models. The validity of this new scheme will be tested eventually by more precise measurements of neutron star radii.Comment: EPJA (2015) in pres

Probing the high-density behavior of symmetry energy with gravitational waves

Gravitational wave (GW) astronomy opens up an entirely new window on the Universe to probe the equations of state (EOS) of neutron-rich matter. With the advent of next generation GW detectors, measuring the gravitational radiation from coalescing binary neutron star systems, mountains on rotating neutron stars, and stellar oscillation modes may become possible in the near future. Using a set of model EOSs satisfying the latest constraints from terrestrial nuclear experiments, state of the art nuclear many-body calculations of the pure neutron matter EOS, and astrophysical observations consistently, we study various GW signatures of the high-density behavior of the nuclear symmetry energy, which is considered among the most uncertain properties of dense neutron-rich nucleonic matter. In particular, we find the tidal polarizability of neutron stars, potentially measurable in binary systems just prior to merger, is more sensitive to the high density component of the nuclear symmetry energy than the symmetry energy at nuclear saturation density. We also find that the upper limit on the GW strain amplitude from elliptically deformed stars is very sensitive to the density dependence of the symmetry energy. This suggests that future developments in modeling of the neutron star crust, and direct gravitational wave signals from accreting binaries will provide a wealth of information on the EOS of neutron-rich matter. We also review the sensitivity of the $r$-mode instability window to the density dependence of the symmetry energy. Whereas models with larger values of the density slope of the symmetry energy at saturation seem to be disfavored by the current observational data, within a simple $r$-mode model, we point out that a subsequent softer behavior of the symmetry energy at high densities (hinted at by recent observational interpretations) could rule them in.Comment: 14 pages, 11 figures, 3 tables; submitted to EPJA Special Volume on Nuclear Symmetry Energ

Deep crustal heating by neutrinos from the surface of accreting neutron stars

We present a new mechanism for deep crustal heating in accreting neutron stars. Charged pions ($\pi^+$) are produced in nuclear collisions on the neutron star surface during active accretion and upon decay they provide a flux of neutrinos into the neutron star crust. For massive and/or compact neutron stars, neutrinos deposit $\approx 1\textrm{--} 2 \, \mathrm{MeV}$ of heat per accreted nucleon into the inner crust. The strength of neutrino heating is comparable to the previously known sources of deep crustal heating, such as from pycnonuclear fusion reactions, and is relevant for studies of cooling neutron stars. We model the thermal evolution of a transient neutron star in a low-mass X-ray binary, and in the particular case of the neutron star MXB~1659-29 we show that additional deep crustal heating requires a higher thermal conductivity for the neutron star inner crust. A better knowledge of pion production cross sections near threshold would improve the accuracy of our predictions.Comment: 12 pages, 9 figures, 3 tables; [Added a new figure and edited the text in response to Referee's remarks and suggestions

Multistep Measurement of Plantar Pressure Alterations Using Metatarsal Pads

Metatarsal pads are frequently prescribed for nonoperative management of metatarsalgia due to various etiologies. When appropriately placed, they are effective in reducing pressures under the metatarsal heads on the plantar surface of the foot. Despite the positive clinical reports that have been cited, there are no quantitative studies documenting the load redistribution effects of these pads during multiple step usage within the shoe environment. The objective of this study was to assess changes in plantar pressure metrics resulting from pad use. Ten normal adult male subjects were tested during a series of 400-step trials. Pressures were recorded from eight discrete plantar locations at the hindfoot, midfoot, and forefoot regions of the insole. Significant increases in peak pressures, contact durations, and pressure-time integrals were noted at the metatarsal shaft region with pad use (P ≤ .05). Statistically significant changes in metric values were not seen at the other plantar locations, although metatarsal pad use resulted in mild decreases in mean peak pressures at the first and second metatarsal heads and slight increases laterally. Contact durations decreased at all metatarsal head locations, while pressure-time integrals decreased at the first, second, third, and fourth metatarsal heads. A slight increase in pressure-time integrals was seen at the fifth metatarsal head. The redistribution of plantar pressures tended to relate not only to the dimensions of the metatarsal pads, but also to foot size, anatomic foot configuration, and pad location. Knowledge of these parameters, along with careful control of pad dimensions and placement, allows use of the metatarsal pad as an effective orthotic device for redistributing forefoot plantar pressures

Sulforaphane induces adipocyte browning and promotes glucose and lipid utilization

Scope: Obesity is closely related to the imbalance of white adipose tissue storing excess calories, and brown adipose tissue dissipating energy to produce heat in mammals. Recent studies revealed that acquisition of brown characteristics by white adipocytes, termed “browning,” may positively contribute to cellular bioenergetics and metabolism homeostasis. The goal was to investigate the putative effects of natural antioxidant sulforaphane (1-isothiocyanate-4-methyl-sulfonyl butane; SFN) on browning of white adipocytes. Methods and Results: 3T3-L1 mature white adipocytes were treated with SFN for 48 h, and then the mitochondrial content, function, and energy utilization were assessed. SFN was found to induce 3T3-L1 adipocytes browning based on the increased mitochondrial content and activity of respiratory chain enzymes, whereas the mechanism involved the upregulation of nuclear factor E2-related factor 2/ sirtuin1/ peroxisome proliferator-activated receptor gamma coactivator 1 alpha signaling. SFN enhanced uncoupling protein 1 expression, a marker for brown adipocyte, leading to the decrease in cellular ATP. SFN also enhanced glucose uptake and oxidative utilization, lipolysis and fatty acid oxidation in 3T3-L1 adipocytes. Conclusion: SFN-induced browning of white adipocytes enhanced the utilization of cellular fuel, and the application of SFN is a promising strategy to combat obesity and obesity-related metabolic disorder