3,431 research outputs found
Aortic calcification and femoral bone density are independently associated with left ventricular mass in patients with chronic kidney disease
Background
Vascular calcification and reduced bone density are prevalent in chronic kidney disease and linked to increased cardiovascular risk. The mechanism is unknown. We assessed the relationship between vascular calcification, femoral bone density and left ventricular mass in patients with stage 3 non-diabetic chronic kidney disease in a cross-sectional observational study.
Methodology and Principal Findings
A total of 120 patients were recruited (54% male, mean age 55±14 years, mean glomerular filtration rate 50±13 ml/min/1.73 m2). Abdominal aortic calcification was assessed using lateral lumbar spine radiography and was present in 48%. Mean femoral Z-score measured using dual energy x-ray absorptiometry was 0.60±1.06. Cardiovascular magnetic resonance imaging was used to determine left ventricular mass. One patient had left ventricular hypertrophy. Subjects with aortic calcification had higher left ventricular mass compared to those without (56±16 vs. 48±12 g/m2, P = 0.002), as did patients with femoral Z-scores below zero (56±15 vs. 49±13 g/m2, P = 0.01). In univariate analysis presence of aortic calcification correlated with left ventricular mass (r = 0.32, P = 0.001); mean femoral Z-score inversely correlated with left ventricular mass (r = −0.28, P = 0.004). In a multivariate regression model that included presence of aortic calcification, mean femoral Z-score, gender and 24-hour systolic blood pressure, 46% of the variability in left ventricular mass was explained (P<0.001).
Conclusions
In patients with stage 3 non-diabetic chronic kidney disease, lower mean femoral Z-score and presence of aortic calcification are independently associated with increased left ventricular mass. Further research exploring the pathophysiology that underlies these relationships is warranted
Carbon Stars and other Luminous Stellar Populations in M33
The M33 galaxy is a nearby, relatively metal-poor, late-type spiral. Its
proximity and almost face-on inclination means that it projects over a large
area on the sky, making it an ideal candidate for wide-field CCD mosaic
imaging. Photometry was obtained for more than 10^6 stars covering a 74' x 56'
field centered on M33. Main sequence (MS), supergiant branch (SGB), red giant
branch (RGB) and asymptotic giant branch (AGB) populations are identified and
classified based on broad-band V and I photometry. Narrow-band filters are used
to measure spectral features allowing the AGB population to be further divided
into C and M-star types. The galactic structure of M33 is examined using star
counts, colour-colour and colour-magnitude selected stellar populations. We use
the C to M-star ratio to investigate the metallicity gradient in the disk of
M33. The C/M-star ratio is found to increase and then flatten with increasing
galactocentric radius in agreement with viscous disk formation models. The
C-star luminosity function is found to be similar to M31 and the SMC,
suggesting that C-stars should be useful distance indicators. The ``spectacular
arcs of carbon stars'' in M33 postulated recently by Block et al. (2004) are
found in our work to be simply an extension of M33's disk.Comment: 20 pages, 20 figures. Accepted for publication in The Astronomical
Journa
Unexpected Magnetism of Small Silver Clusters
The ground-state electronic, structural, and magnetic properties of small
silver clusters, Ag (2n22), have been studied using a linear
combination of atomic Gaussian-type orbitals within the density functional
theory. The results show that the silver atoms, which are diamagnetic in bulk
environment, can be magnetic when they are grouped together in clusters. The
Ag cluster with icosahedral symmetry has the highest magnetic moment per
atom among the studied silver clusters. The cluster symmetry and the reduced
coordination number specific of small clusters reveal as a fundamental factor
for the onset of the magnetism.Comment: 4 pages, 4 figure
Doping and Irradiation Controlled Vortex Pinning Behavior in BaFe2(As1-xPx)2 Single Crystals
We report on the systematic evolution of vortex pinning behavior in isovalent
doped single crystals of BaFe2(As1-xPx)2. Proceeding from optimal doped to
ovedoped samples, we find a clear transfor- mation of the magnetization
hysteresis from a fishtail behavior to a distinct peak effect followed by a
reversible magnetization and Bean Livingston surface barriers. Strong point
pinning dominates the vortex behavior at low fields whereas weak collective
pinning determines the behavior at higher fields. In addition to doping
effects, we show that particle irradiation by energetic protons can tune vortex
pinning in these materials.Comment: 4 pages, 4 figures,significant change of eraly version, accepted by
PRB rapid communication
Searching for music: understanding the discovery, acquisition, processing and organization of music in a domestic setting for design
This series of studies make it clear that a wide range of both physical and digital resources are involved in domestic music consumption. The selection of digital resources is particularly evident, and it can be observed that domestic music consumption is a fragmented business, taking advantage of many different "channels'' for getting, using and preparing music. While there are not a series of common channels, each home displayed a variety of methods in respect to using metadata in multiple different modalities: regardless, the activities involved in getting, using and preparing music cohere through a noticeable, emergent set of workflows. We find that not only does metadata support searching, as one might expect, but also it pervades all parts of the workflow and is used in real-time as a reflexive artifact and in terms of its future perceived/prescribed use. The findings of the research raise a series of possibilities and issues that form the basis for understanding and designing for metadata use
Visions, values, and videos: Revisiting envisionings in service of UbiComp design for the home
UbiComp has been envisioned to bring about a future dominated by calm computing technologies making our everyday lives ever more convenient. Yet the same vision has also attracted criticism for encouraging a solitary and passive lifestyle. The aim of this paper is to explore and elaborate these tensions further by examining the human values surrounding future domestic UbiComp solutions. Drawing on envisioning and contravisioning, we probe members of the public (N=28) through the presentation and focus group discussion of two contrasting animated video scenarios, where one is inspired by 'calm' and the other by 'engaging' visions of future UbiComp technology. By analysing the reasoning of our participants, we identify and elaborate a number of relevant values involved in balancing the two perspectives. In conclusion, we articulate practically applicable takeaways in the form of a set of key design questions and challenges
Bitopic binding mode of an M1 muscarinic acetylcholine receptor agonist associated with adverse clinical trial outcomes
The realisation of the therapeutic potential of targeting the M1 muscarinic acetylcholine receptor (M1 mAChR) for the treatment of cognitive decline in Alzheimer's disease has prompted the discovery of M1 mAChR ligands showing efficacy in alleviating cognitive dysfunction in both rodents and humans. Among these is GSK1034702, described previously as a potent M1 receptor allosteric agonist, which showed pro-cognitive effects in rodents and improved immediate memory in a clinical nicotine withdrawal test but induced significant side-effects. Here we provide evidence using ligand binding, chemical biology and functional assays to establish that rather than the allosteric mechanism claimed, GSK1034702 interacts in a bitopic manner at the M1 mAChR such that it can concomitantly span both the orthosteric and an allosteric binding site. The bitopic nature of GSK1034702 together with the intrinsic agonist activity and a lack of muscarinic receptor subtype selectivity reported here, all likely contribute to the adverse effects of this molecule in clinical trials. We conclude that these properties, whilst imparting beneficial effects on learning and memory, are undesirable in a clinical candidate due to the likelihood of adverse side effects. Rather, our data supports the notion that "pure" positive allosteric modulators showing selectivity for the M1 mAChR with low levels of intrinsic activity would be preferable to provide clinical efficacy with low adverse responses
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