Data Compression System with a Minimum Time Delay Unit-Patent

Minimum time delay unit for conventional time multiplexed data compression channel

Keiretsu and Relationship-Specific Investment: A Barrier to Trade?

This paper develops a model of informal procurement within Japanese keiretsu so as to consider effects on intermediate-good imports, such as auto parts. Parts-suppliers make relationship-specific investments that benefit the auto-maker and prices are determined by bargaining after investment has been sunk. Although this investment raises efficiency, it limits the range of imports to less important parts such as tail pipes and it is possible that no parts are imported, despite lower foreign production costs. Lack of information concerning investment rents combined with counterintuitive effects on imports and Japanese production costs could create unwarranted perceptions of a trade barrier.

Keiretsu and Relationship-Specific Investment: Implications for Market-Opening Trade Policy

This paper considers the implications of relationship-specific investment within keiretsu for policies aimed at opening the Japanese market for intermediate goods, such as auto parts. Both VIEs applied to parts and VERs restricting Japanese exports of autos cause the keiretsu to import a wider range of parts, but of a relatively unimportant type, such as seat covers. Since keiretsu investment and output fall, the total value of U.S. parts exports may actually fall. For a given value of these exports, a VIE is less costly for U.S. consumers and Japanese producers, but a VER is preferred by U.S. automakers.

ERTS image data compression technique evaluation

There are no author-identified significant results in this report

Magmatic intrusions control Io's crustal thickness

Io, the most volcanically active body in the solar system, loses heat through eruptions of hot lava. Heat is supplied by tidal heating and is thought to be transferred through the mantle by magmatic segregation, a mode of transport that sets it apart from convecting terrestrial planets. We present a model that couples magmatic transport of tidal heat to the volcanic system in the crust, in order to determine the controls on crustal thickness, magmatic intrusions, and eruption rates. We demonstrate that magmatic intrusions are a key component of Io's crustal heat balance; around 80% of the magma delivered to the base of the crust must be emplaced and frozen as plutons to match rough estimates of crustal thickness. As magma ascends from a partially molten mantle into the crust, a decompacting boundary layer forms, which can explain inferred observations of a high-melt-fraction region.Comment: Accepted to JGR:Planets. 24 pages inc appendices and references. 7 figure

TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells

Using a screening strategy, we identified the tetratricopeptide repeat (TPR) motif protein, Tetratricopeptide repeat domain 5 (TTC5, also known as stress responsive activator of p300 or Strap) as required for the survival of human acute myeloid leukemia (AML) cells. TTC5 is a stress-inducible transcription cofactor known to interact directly with the histone acetyltransferase EP300 to augment the TP53 response. Knockdown (KD) of TTC5 induced apoptosis of both murine and human AML cells, with concomitant loss of clonogenic and leukemia-initiating potential; KD of EP300 elicited a similar phenotype. Consistent with the physical interaction of TTC5 and EP300, the onset of apoptosis following KD of either gene was preceded by reduced expression of BCL2 and increased expression of pro-apoptotic genes. Forced expression of BCL2 blocked apoptosis and partially rescued the clonogenic potential of AML cells following TTC5 KD. KD of both genes also led to the accumulation of MYC, an acetylation target of EP300, and the form of MYC that accumulated exhibited relative hypoacetylation at K148 and K157, residues targeted by EP300. In view of the ability of excess cellular MYC to sensitize cells to apoptosis, our data suggest a model whereby TTC5 and EP300 cooperate to prevent excessive accumulation of MYC in AML cells and their sensitization to cell death. They further reveal a hitherto unappreciated role for TTC5 in leukemic hematopoiesis

Racial/Ethnic Disparities in Diabetes Care and Outcomes: A Mixed Methods Study

Limited research has examined racial/ethnic differences in diabetes care and outcomes among primary care patients. This study examined racial/ethnic differences in diabetes care and outcomes among an ambulatory patient population and explored patient perceptions of the patient-provider relationship to inform strategies to improve care delivery. Using data from 62,149 adults with diabetes who received care within Atrium Health in 2013, regression models assessed associations between race/ethnicity and the following outcomes: glycated hemoglobin (HbA1c) tests, low density lipoprotein (LDL) and blood pressure (BP) screening, foot and eye exams, and HbA1c, LDL, and BP control. Eleven patients with diabetes and uncontrolled hypertension participated in three focus groups about their perceptions of the patient-provider relationship. Compared to non-Hispanic Whites, non-Hispanic Blacks had 22% to 73% higher odds of receiving screenings (HbA1c, LDL, BP, foot and eye exams;

A Matrix Hyperbolic Cosine Algorithm and Applications

In this paper, we generalize Spencer's hyperbolic cosine algorithm to the matrix-valued setting. We apply the proposed algorithm to several problems by analyzing its computational efficiency under two special cases of matrices; one in which the matrices have a group structure and an other in which they have rank-one. As an application of the former case, we present a deterministic algorithm that, given the multiplication table of a finite group of size $n$, it constructs an expanding Cayley graph of logarithmic degree in near-optimal O(n^2 log^3 n) time. For the latter case, we present a fast deterministic algorithm for spectral sparsification of positive semi-definite matrices, which implies an improved deterministic algorithm for spectral graph sparsification of dense graphs. In addition, we give an elementary connection between spectral sparsification of positive semi-definite matrices and element-wise matrix sparsification. As a consequence, we obtain improved element-wise sparsification algorithms for diagonally dominant-like matrices.Comment: 16 pages, simplified proof and corrected acknowledging of prior work in (current) Section