22,722 research outputs found

    Bootstrapping trust evaluations through stereotypes

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    The effect of small-amplitude time-dependent changes to the surface morphology of a sphere

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    Typical approaches to manipulation of flow separation employ passive means or active techniques such as blowing and suction or plasma acceleration. Here it is demonstrated that the flow can be significantly altered by making small changes to the shape of the surface. A proof of concept experiment is performed using a very simple time-dependent perturbation to the surface of a sphere: a roughness element of 1% of the sphere diameter is moved azimuthally around a sphere surface upstream of the uncontrolled laminar separation point, with a rotational frequency as large as the vortex shedding frequency. A key finding is that the non-dimensional time to observe a large effect on the lateral force due to the perturbation produced in the sphere boundary layers as the roughness moves along the surface is ˆt =tU_(∞)/D ≈4. This slow development allows the moving element to produce a tripped boundary layer over an extended region. It is shown that a lateral force can be produced that is as large as the drag. In addition, simultaneous particle image velocimetry and force measurements reveal that a pair of counter-rotating helical vortices are produced in the wake, which have a significant effect on the forces and greatly increase the Reynolds stresses in the wake. The relatively large perturbation to the flow-field produced by the small surface disturbance permits the construction of a phase-averaged, three-dimensional (two-velocity component) wake structure from measurements in the streamwise/radial plane. The vortical structure arising due to the roughness element has implications for flow over a sphere with a nominally smooth surface or distributed roughness. In addition, it is shown that oscillating the roughness element, or shaping its trajectory, can produce a mean lateral force

    Relative status and well-being: evidence from U.S. suicide deaths

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    This paper empirically assesses the theory of interpersonal income comparison using individual level data on suicide deaths in the United States. We model suicide as a choice variable, conditional on exogenous risk factors, reflecting an individual's assessment of current and expected future utility. Our empirical analysis considers whether suicide risk is systematically related to the income of others, holding own income and other individual factors fixed. We estimate proportional hazards and probit models of the suicide hazard using two separate and independent data sets: (1) the National Longitudinal Mortality Study and (2) the Detailed Mortality Files combined with the 5 percent Public Use Micro Sample of the 1990 decennial census. Results from both data sources show that, controlling for own income and individual characteristics, individual suicide risk rises with reference group income. This result holds for reference groups defined broadly, such as by county, and more narrowly by county and one demographic marker (e.g., age, sex, race). These findings are robust to alternative specifications and cannot be explained by geographic variation in cost of living, access to emergency medical care, mismeasurement of deaths by suicide, or by bias due to endogeneity of own income. Our results confirm findings using self-reported happiness data and are consistent with models of utility featuring "external habit" or "Keeping Up with the Joneses" preferences.Income distribution ; Suicide

    Temperature dependent characterization of optical fibres for distributed temperature sensing in hot geothermal wells

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    This study was performed in order to select a proper fibre for the application of a distributed temperature sensing system within a hot geothermal well in Iceland. Commercially available high temperature graded index fibres have been tested under in-situ temperature conditions. Experiments have been performed with four different polyimide coated fibres, a fibre with an aluminum coating and a fibre with a gold coating. To select a fibre, the relationship between attenuation, temperature, and time has been analyzed together with SEM micrographs. On the basis of these experiments, polyimide fibres have been chosen for utilisation. Further tests in ambient and inert atmosphere have been conducted with two polyimide coated fibres to set an operating temperature limit for these fibres. SEM micrographs, together with coating colour changes have been used to characterize the high temperature performance of the fibres. A novel cable design has been developed, a deployment strategy has been worked out and a suitable well for deployment has been selected.Comment: PACS: 42.81.Pa, 93.85.Fg, 47.80.Fg, 91.35.Dc, 07.20.Dt, 07.60.V

    Impaired osteoblast differentiation in annexin A2- and -A5-deficient cells.

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    Annexins are a class of calcium-binding proteins with diverse functions in the regulation of lipid rafts, inflammation, fibrinolysis, transcriptional programming and ion transport. Within bone, they are well-characterized as components of mineralizing matrix vesicles, although little else is known as to their function during osteogenesis. We employed shRNA to generate annexin A2 (AnxA2)- or annexin A5 (AnxA5)-knockdown pre-osteoblasts, and determined whether proliferation or osteogenic differentiation was altered in knockdown cells, compared to pSiren (Si) controls. We report that DNA content, a marker of proliferation, was significantly reduced in both AnxA2 and AnxA5 knockdown cells. Alkaline phosphatase expression and activity were also suppressed in AnxA2- or AnxA5-knockdown after 14 days of culture. The pattern of osteogenic gene expression was altered in knockdown cells, with Col1a1 expressed more rapidly in knock-down cells, compared to pSiren. In contrast, Runx2, Ibsp, and Bglap all revealed decreased expression after 14 days of culture. In both AnxA2- and AnxA5-knockdown, interleukin-induced STAT6 signaling was markedly attenuated compared to pSiren controls. These data suggest that AnxA2 and AnxA5 can influence bone formation via regulation of osteoprogenitor proliferation, differentiation, and responsiveness to cytokines in addition to their well-studied function in matrix vesicles
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