521 research outputs found
Tear film thickness variations and the role of the tear meniscus
A mathematical model is developed to investigate the two-dimensional variations in the thickness of tear fluid deposited on the eye surface during a blink. Such variations can become greatly enhanced as the tears evaporate during the interblink period.\ud
The four mechanisms considered are: i) the deposition of the tear film from the upper eyelid meniscus, ii) the flow of tear fluid from under the eyelid as it is retracted and from the lacrimal gland, iii) the flow of tear fluid around the eye within the meniscus and iv) the drainage of tear fluid into the canaliculi through the inferior and superior puncta.\ud
There are two main insights from the modelling. First is that the amount of fluid within the tear meniscus is much greater than previously employed in models and this significantly changes the predicted distribution of tears. Secondly the uniformity of the tear film for a single blink is: i) primarily dictated by the storage in the meniscus, ii) quite sensitive to the speed of the blink and the ratio of the viscosity to the surface tension iii) less sensitive to the precise puncta behaviour, the flow under the eyelids or the specific distribution of fluid along the meniscus at the start of the blink. The modelling briefly examines the flow into the puncta which interact strongly with the meniscus and acts to control the meniscus volume. In addition it considers flow from the lacrimal glands which appears to occurs continue even during the interblink period when the eyelids are stationary
The 2MASS Wide-Field T Dwarf Search. IV Unting out T dwarfs with Methane Imaging
We present first results from a major program of methane filter photometry
for low-mass stars and brown dwarfs. The definition of a new methane filter
photometric system is described. A recipe is provided for the differential
calibration of methane imaging data using existing 2MASS photometry. We show
that these filters are effective in discriminating T dwarfs from other types of
stars, and demonstrate this with Anglo-Australian Telescope observations using
the IRIS2 imager. Methane imaging data and proper motions are presented for ten
T dwarfs identified as part of the 2MASS "Wide Field T Dwarf Search" -- seven
of them initially identified as T dwarfs using methane imaging.
We also present near-infrared moderate resolution spectra for five T dwarfs,
newly discovered by this technique. Spectral types obtained from these spectra
are compared to those derived from both our methane filter observations, and
spectral types derived by other observers. Finally, we suggest a range of
future programs to which these filters are clearly well suited: the winnowing
of T dwarf and Y dwarf candidate objects coming from the next generation of
near-infrared sky surveys; the robust detection of candidate planetary-mass
brown dwarfs in clusters; the detection of T dwarf companions to known L and T
dwarfs via deep methane imaging; and the search for rotationally-modulated
time-variable surface features on cool brown dwarfs.Comment: 20 pages. To appear in The Astronomical Journal, Nov. 200
Modeling the growth of multicellular cancer spheroids in a\ud bioengineered 3D microenvironment and their treatment with an\ud anti-cancer drug
A critical step in the dissemination of ovarian cancer cells is the formation of multicellular spheroids from cells shed from the primary tumor. The objectives of this study were to establish and validate bioengineered three-dimensional (3D) microenvironments for culturing ovarian cancer cells in vitro and simultaneously to develop computational models describing the growth of multicellular spheroids in these bioengineered matrices. Cancer cells derived from human epithelial ovarian carcinoma were embedded within biomimetic hydrogels of varying stiffness and cultured for up to 4 weeks. Immunohistochemistry was used to quantify the dependence of cell proliferation and apoptosis on matrix stiffness, long-term culture and treatment with the anti-cancer drug paclitaxel.\ud
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Two computational models were developed. In the first model, each spheroid was treated as an incompressible porous medium, whereas in the second model the concept of morphoelasticity was used to incorporate details about internal stresses and strains. Each model was formulated as a free boundary problem. Functional forms for cell proliferation and apoptosis motivated by the experimental work were applied and the predictions of both models compared with the output from the experiments. Both models simulated how the growth of cancer spheroids was influenced by mechanical and biochemical stimuli including matrix stiffness, culture time and treatment with paclitaxel. Our mathematical models provide new perspectives on previous experimental results and have informed the design of new 3D studies of multicellular cancer spheroids
Growth of confined cancer spheroids: a combined experimental and mathematical modelling approach
We have integrated a bioengineered three-dimensional platform by generating multicellular cancer spheroids in a controlled microenvironment with a mathematical model to investigate\ud
confined tumour growth and to model its impact on cellular processes
ATLAST detector needs for direct spectroscopic biosignature characterization in the visible and near-IR
Are we alone? Answering this ageless question will be a major focus for
astrophysics in coming decades. Our tools will include unprecedentedly large
UV-Optical-IR space telescopes working with advanced coronagraphs and
starshades. Yet, these facilities will not live up to their full potential
without better detectors than we have today. To inform detector development,
this paper provides an overview of visible and near-IR (VISIR;
) detector needs for the Advanced Technology
Large Aperture Space Telescope (ATLAST), specifically for spectroscopic
characterization of atmospheric biosignature gasses. We also provide a brief
status update on some promising detector technologies for meeting these needs
in the context of a passively cooled ATLAST.Comment: 8 pages, Presented 9 August 2015 at SPIE Optics + Photonics, San
Diego, C
Rapid VAC high dose melphalan regimen, a novel chemotherapy approach in childhood soft tissue sarcomas.
Forty-three children with malignant soft tissue sarcomas (IRS Groups II-IV) were treated with rapid dose delivery chemotherapy protocol comprising six courses of vincristine, adriamycin and cyclophosphamide, given in most cases within 8 weeks (Rapid VAC). This was followed in 36 patients by high dose melphalan with autologous bone marrow rescue. Twenty-six patients also received irradiation to the site of primary tumour. The Rapid VAC regimen was well tolerated and largely administered as an out-patient. There was one toxic death which occurred 2 months after high dose melphalan due to a combination of infection and possible anthracycline cardiomyopathy. Stages were, (Intergroup Rhabdomyosarcoma Study (IRS) system) Group, Group II--four patients. Group III--27 patients and Group IV--12 patients; International Society of Paediatric Oncology (SIOP) staging, Stage I--11, Stage II--13, Stage III--7, Stage IV--12. Actuarial survival at 5 years for all stages is 57% and event free survival 44%. For patients with non-metastatic diseases, 62% and 53% respectively. This treatment strategy utilises the philosophy of rapid drug delivery with high dose consolidation and enables all chemotherapy to be finished within a 4 month period. In general, a conservative approach was applied to both radiation and surgery to minimise late sequelae related to these treatment modalities. Although the small number of high risk patients in this study limits conclusions regarding efficacy in these subgroups the overall results with this regimen appear to be comparable to that with other approaches
Diffraction Limited Imaging Spectroscopy of the SgrA* Region using OSIRIS, a new Keck Instrument
We present diffraction limited spectroscopic observations of an infrared
flare associated with the radio source SgrA*. These are the first results
obtained with OSIRIS, the new facility infrared imaging spectrograph for the
Keck Observatory operated with the laser guide star adaptive optics system.
After subtracting the spectrum of precursor emission at the location of Sgr A*,
we find the flare has a spectral index of -2.6 +- 0.9. If we do not subtract
the precursor light, then our spectral index is consistent with earlier
observations by Ghez et al. (2005). All observations published so far suggest
that the spectral index is a function of the flare's K-band flux.Comment: paper accepted for publication in ApJ Letter
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