1,148 research outputs found
Correlation of Aqueous Solubility and Anti-Cancer Activity of Novel Triazolium and Imidazolium Salts
Novel triazolium, imidazolium, and benzimidazolium salts are known to possess anti-cancer properties and have potential as cancer therapeutics. This thesis describes the aqueous solubility and the differential activity of N,AT-bis-substituted-l,2,4-triazolium bromide salts and N/N\u27-bis(naphthylmethyl)imidazolium bromide salts against MDA-MB-468 breast cancer cells and PC-3 prostate carcinomas. Using a microscale technique, the partition coefficient (log P) of each salt was determined. The log P value was explored to determine the bioavailability of each derivative
Phonon Dispersion Effects and the Thermal Conductivity Reduction in GaAs/AlAs Superlattices
The experimentally observed order-of-magnitude reduction in the thermal
conductivity along the growth axis of (GaAs)_n/(AlAs)_n (or n x n)
superlattices is investigated theoretically for (2x2), (3x3) and (6x6)
structures using an accurate model of the lattice dynamics. The modification of
the phonon dispersion relation due to the superlattice geometry leads to
flattening of the phonon branches and hence to lower phonon velocities. This
effect is shown to account for a factor-of-three reduction in the thermal
conductivity with respect to bulk GaAs along the growth direction; the
remainder is attributable to a reduction in the phonon lifetime. The
dispersion-related reduction is relatively insensitive to temperature (100 < T
< 300K) and n. The phonon lifetime reduction is largest for the (2x2)
structures and consistent with greater interface scattering. The thermal
conductivity reduction is shown to be appreciably more sensitive to GaAs/AlAs
force constant differences than to those associated with molecular masses.Comment: 5 figure
Statistical Properties of Many Particle Eigenfunctions
Wavefunction correlations and density matrices for few or many particles are
derived from the properties of semiclassical energy Green functions. Universal
features of fixed energy (microcanonical) random wavefunction correlation
functions appear which reflect the emergence of the canonical ensemble as the
number of particles approaches infinity. This arises through a little known
asymptotic limit of Bessel functions. Constraints due to symmetries,
boundaries, and collisions between particles can be included.Comment: 13 pages, 4 figure
Eigenstate Structure in Graphs and Disordered Lattices
We study wave function structure for quantum graphs in the chaotic and
disordered regime, using measures such as the wave function intensity
distribution and the inverse participation ratio. The result is much less
ergodicity than expected from random matrix theory, even though the spectral
statistics are in agreement with random matrix predictions. Instead, analytical
calculations based on short-time semiclassical behavior correctly describe the
eigenstate structure.Comment: 4 pages, including 2 figure
Recent Decisions
Comments on recent decisions by Edward M. O\u27Toole, John J. Coffey, Richard M. Bies, Thomas Kavadas, Jr., J. Michael Guenther, John R. Martzell, William J. Luff, William R. Kennedy, Thomas L. Shaffer, and Paul J. Schierl
Recent Decisions
Comments on recent decisions by Edward M. O\u27Toole, John J. Coffey, Richard M. Bies, Thomas Kavadas, Jr., J. Michael Guenther, John R. Martzell, William J. Luff, William R. Kennedy, Thomas L. Shaffer, and Paul J. Schierl
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