748 research outputs found
Calculation of the Density of States Using Discrete Variable Representation and Toeplitz Matrices
A direct and exact method for calculating the density of states for systems
with localized potentials is presented. The method is based on explicit
inversion of the operator . The operator is written in the discrete
variable representation of the Hamiltonian, and the Toeplitz property of the
asymptotic part of the obtained {\it infinite} matrix is used. Thus, the
problem is reduced to the inversion of a {\it finite} matrix
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BRAIN-STEM-EVOKED POTENTIALS IN THE DIAGNOSIS OF POSTERIOR-FOSSA TUMORS IN CHILDREN
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SURGICAL-MANAGEMENT OF PROGRESSIVE VISUAL-LOSS IN OPTIC GLIOMAS OF CHILDHOOD
Diffusional Relaxation in Random Sequential Deposition
The effect of diffusional relaxation on the random sequential deposition
process is studied in the limit of fast deposition. Expression for the coverage
as a function of time are analytically derived for both the short-time and
long-time regimes. These results are tested and compared with numerical
simulations.Comment: 9 pages + 2 figure
Deposition of general ellipsoidal particles
We present a systematic overview of granular deposits composed of ellipsoidal
particles with different particle shapes and size polydispersities. We study
the density and anisotropy of such deposits as functions of size polydispersity
and two shape parameters that fully describe the shape of a general ellipsoid.
Our results show that, while shape influences significantly the macroscopic
properties of the deposits, polydispersity plays apparently a secondary role.
The density attains a maximum for a particular family of non-symmetrical
ellipsoids, larger than the density observed for prolate or oblate ellipsoids.
As for anisotropy measures, the contact forces show are increasingly preferred
along the vertical direction as the shape of the particles deviates for a
sphere. The deposits are constructed by means of an efficient molecular
dynamics method, where the contact forces are efficiently and accurately
computed. The main results are discussed in the light of applications for
porous media models and sedimentation processes.Comment: 7 pages, 8 figure
The effect of 'Astressin', a novel antagonist of corticotropin releasing hormone (CRH), on CRH-induced seizures in the infant rat: comparison with two other antagonists.
Corticotropin releasing hormone (CRH) has both neuroendocrine effects, promoting ACTH release from the anterior pituitary, and neurotransmitter properties, acting on specific neuronal populations. A recently designed CRH analogue has been shown to be highly potent in preventing activation of pituitary CRH receptors. The efficacy of this compound, 'Astressin', in blocking the effects of CRH in the central nervous system (CNS) has not been determined. CRH induces prolonged amygdala-origin seizures in neonatal and infant rats. This model was used in the current study, to compare Astressin to alpha-helical CRH-(9-41), and to [D-Phe12, Nle21.38, C-MeLeu37]CRH-(12-41), i.e. D-Phe-CRH-(12-41). Astressin (3 or 10 micrograms) was infused into the cerebral ventricles of infant rats prior to CRH infusion. Both doses of the analogue significantly delayed the onset of CRH-induced seizures when given 15, but not 30 min before CRH. No effect of the lower Astressin dose on seizure duration was demonstrated; the higher dose prevented seizures in 2/12 rats, and delayed seizure onset in the others (22.7 +/- 5 min vs 10.1 +/- 1.3 min). In the same paradigm, 10 micrograms of alpha-helical CRH-(9-41) and 5 micrograms of D-Phe-CRH-(12-41) had comparable effects on seizure latency and duration. Electroencephalograms confirmed the behavioral effects of Astressin. Therefore, in a CNS model of CRH-mediated neurotransmission, the potency of Astressin is not substantially higher than that of alpha-helical CRH (9-41) and D-Phe-CRH-(12-41)
Competitive random sequential adsorption of point and fixed-sized particles: analytical results
We study the kinetics of competitive random sequential adsorption (RSA) of
particles of binary mixture of points and fixed-sized particles within the
mean-field approach. The present work is a generalization of the random car
parking problem in the sense that it considers the case when either a car of
fixed size is parked with probability q or the parking space is partitioned
into two smaller spaces with probability (1-q) at each time event. This allows
an interesting interplay between the classical RSA problem at one extreme
(q=1), and the kinetics of fragmentation processes at the other extreme (q=0).
We present exact analytical results for coverage for a whole range of q values,
and physical explanations are given for different aspects of the problem. In
addition, a comprehensive account of the scaling theory, emphasizing on
dimensional analysis, is presented, and the exact expression for the scaling
function and exponents are obtained.Comment: 7 pages, latex, 3 figure
Spatial and temporal evolution of neuronal activation, stress and injury in lithium-pilocarpine seizures in adult rats.
In order to follow the spatial and temporal evolution of neuronal damage, cellular activation and stress responses subsequent to lithium-pilocarpine seizures of various durations in the adult rat, we analyzed the expression of Fos protein and local cerebral glucose utilization as markers of cellular activation, HSP72 immunoreactivity and acid fuchsin staining as indicators of cellular stress and injury, and Cresyl violet staining for the assessment of neuronal damage. The expression of Fos appeared very early, 2-30 min after the onset of polyspikes and intensified during the following 4 h. Fos immunoreactivity was especially high in the hippocampus, cerebral cortex, amygdala and anterior olfactory nuclei. Local cerebral glucose utilization measured during the second hour of seizures was largely increased (350-580%) over control levels in cortical areas, amygdala, dentate gyrus, caudate nucleus and mediodorsal thalamus. HSP72 immunoreactivity never appeared earlier than 40-50 min after the onset of polyspikes, and was most prominent in hippocampal CA3 area, cerebral cortex (except the piriform cortex) and anterior olfactory nuclei. Acid fuchsin staining was maximal in the piriform cortex and the polymorphic layer of the dentate gyrus. Staining was moderate in the sensorimotor cortex and the amygdala. Neuronal damage was extensive in the piriform and entorhinal cortices, the hippocampal CA3 area and the polymorphic layer of the dentate gyrus, basal amygdala, mediodorsal thalamus and anterior olfactory nuclei. In conclusion, the present study shows that brain regions with the highest expression of Fos and the largest metabolic activation were also highly stained with acid fuchsin and most heavily damaged. Conversely, there is no clear relationship between HSP72 expression, cellular activation and neuronal damage
Superdiffusion of massive particles induced by multi-scale velocity fields
We study drag-induced diffusion of massive particles in scale-free velocity
fields, where superdiffusive behavior emerges due to the scale-free size
distribution of the vortices of the underlying velocity field. The results show
qualitative resemblance to what is observed in fluid systems, namely the
diffusive exponent for the mean square separation of pairs of particles and the
preferential concentration of the particles, both as a function of the response
time.Comment: 5 pages, 5 figures. Accepted for publication in EP
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