73 research outputs found
Monitoring of brain and systemic oxygenation in neurocritical care patients.
Maintenance of adequate oxygenation is a mainstay of intensive care, however, recommendations on the safety, accuracy, and the potential clinical utility of invasive and non-invasive tools to monitor brain and systemic oxygenation in neurocritical care are lacking. A literature search was conducted for English language articles describing bedside brain and systemic oxygen monitoring in neurocritical care patients from 1980 to August 2013. Imaging techniques e.g., PET are not considered. A total of 281 studies were included, the majority described patients with traumatic brain injury (TBI). All tools for oxygen monitoring are safe. Parenchymal brain oxygen (PbtO2) monitoring is accurate to detect brain hypoxia, and it is recommended to titrate individual targets of cerebral perfusion pressure (CPP), ventilator parameters (PaCO2, PaO2), and transfusion, and to manage intracranial hypertension, in combination with ICP monitoring. SjvO2 is less accurate than PbtO2. Given limited data, NIRS is not recommended at present for adult patients who require neurocritical care. Systemic monitoring of oxygen (PaO2, SaO2, SpO2) and CO2 (PaCO2, end-tidal CO2) is recommended in patients who require neurocritical care
Mode-hop-free tuning over 135 GHz of external cavity diode lasers without anti-reflection coating
We report an external cavity diode laser (ECDL), using a diode whose front
facet is not antireflection (AR) coated, that has a mode-hop-free (MHF) tuning
range greater than 135 GHz. We achieved this using a short external cavity and
by simultaneously tuning the internal and external modes of the laser. We find
that the precise location of the pivot point of the grating in our laser is
less critical than commonly believed. The general applicability of the method,
combined with the compact portable mechanical and electronic design, makes it
well suited for both research and industrial applications.Comment: 5 pages, 5 figure
Acute Posterior Cranial Fossa HemorrhageâIs Surgical Decompression Better than Expectant Medical Management?
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Timing of tracheotomy in ICU patients: a systematic review of randomized controlled trials
Airway management and mechanical ventilation in acute brain injury.
Patients with acute neurologic disease often develop respiratory failure, the management of which profoundly affects brain physiology and long-term functional outcomes. This chapter reviews airway management and mechanical ventilation of patients with acute brain injury, offering practical strategies to optimize treatment of respiratory failure and minimize secondary brain injury. Specific concerns that are addressed include physiologic changes during intubation and ventilation such as the effects on intracranial pressure and brain perfusion; cervical spine management during endotracheal intubation; the role of tracheostomy; and how ventilation and oxygenation are utilized to minimize ischemia-reperfusion injury and cerebral metabolic distress
Irradiance and phase control with two freeform surfaces using partial differential equations
A design method of two coupled freeform surfaces for the control of the irradiance and phase of the input and output wavefronts without the restriction to paraxiality or spherical/planar wavefronts is presented. It can be applied to the design of coupled lens surfaces, coupled mirrors or the combination of lens and mirror surfaces. The method is based on the description of the freeform surfaces through a system of coupled partial differential equations (PDE) for the first freeform surface and a ray-mapping projection. By calculating the required output wavefront between two predefined complex illumination patterns, we demonstrate that the presented algorithm can be applied directly to the calculation of a single optical element for the generation of two different irradiance distributions on separated target planes. Additionally, a manufacturing analysis of the corresponding freeform surfaces of a double lens system is provided. Furthermore, an extension of the design approach for a single freeform lenses with a predefined entrance surface from [J. Opt. Soc. Am. A 34, 1490-1499 (2017)] to single freeform lenses with a predefined exit surface is presentend. Limitations of the design method and possible improvements are discussed
- âŠ