175 research outputs found
Employment, Unemployment and the Health of Pregnant Women
Much of what little we know about the impact of unemployment or health is based upon data or studies of predominantly unemployed men. These studies, though weak in methodology, imply that unemployment may lead to excess morbidity and mortality. This paper reports a study of 4,000 pregnant women in Brisbane. Unemployment amongst women is associated with high-risk health behaviour, which in turn may lead to low birthweight births. Further, unemployed women are more anxious and depressed than are employed women. The mental health of the mother appears to be more closely related to the employment status of her spouse than to her own employment status
Distinguishing cancerous from non-cancerous cells through analysis of electrical noise
Since 1984, electric cell-substrate impedance sensing (ECIS) has been used to
monitor cell behavior in tissue culture and has proven sensitive to cell
morphological changes and cell motility. We have taken ECIS measurements on
several cultures of non-cancerous (HOSE) and cancerous (SKOV) human ovarian
surface epithelial cells. By analyzing the noise in real and imaginary
electrical impedance, we demonstrate that it is possible to distinguish the two
cell types purely from signatures of their electrical noise. Our measures
include power-spectral exponents, Hurst and detrended fluctuation analysis, and
estimates of correlation time; principal-component analysis combines all the
measures. The noise from both cancerous and non-cancerous cultures shows
correlations on many time scales, but these correlations are stronger for the
non-cancerous cells.Comment: 8 pages, 4 figures; submitted to PR
The Population Structure of Ten Newfoundland Outports
This is the published version. Copyright 2000 Wayne State University Press.Island populations are most informative in the study of the genetic structure of human aggregates. These populations are often of small size, thus violating the Hardy-Weinberg assumption of infinite size.
Some geographically isolated island populations are further subdivided by religion, ethnicity, and socioeconomic factors, reducing their effective sizes and facilitating genetic changes due to stochastic processes. Because of extreme geographic and social isolation, fishing communities or outports of Newfoundland have been investigated for genetic micro-differentiation through the founder effect and genetic drift (Crawford et al. 1995). The purpose of this paper is to examine the population structure of 10 Newfoundland outports using the allelic frequencies derived from 12 red cell antigens. To achieve this goal, first we calculated gene frequencies using maximum-likelihood estimation procedures. Second, we used /{-matrix methods to explore population differentiation. Third, we regressed mean per-locus heterozygosity on genetic distance from the gene frequency centroid to identify the most isolated populations. On the basis of this information, the three outports of Seal Cove, Island Harbor, and Tilting were found to be genetically differentiated from the other small populations. Moreover, religious and geographic subdivisions appear to explain the observed genetic variation
Socio-Economic Status and Pregnancy Outcome: An Australian Study
A prospective cohort of 8556 pregnant women attending the Mater Misericordiae Mothers' Hospital in Brisbane was examined to consider the impact of socio-economic status on pregnancy outcome. The indicators of socio-economic status selected were family income, maternal education and paternal occupational status. Pregnancy outcomes considered were preterm delivery, low birthweight, low birthweight for gestational age, and perinatal death. Subsidiary analyses were also undertaken for Apgar scores, time to establish respiration, need for mechanical respiration and admission to intensive care. Before adjustment, the main consistent association was between the occupational status of the father and three measures of perinatal morbidity. Initial adjustment for the mother's socio-demographic background and weight/height ratio reduced the strength and statistical significance of the above associations, while further adjustment for lifestyle variations between the three status groups further reduced the above associations to marginal statistical significance. The findings suggest that observed class differences in pregnancy outcome are attributable to the mother's personal characteristics (height/weight, parity) and her lifestyle
Real-world experience among patients with relapsed/refractory mantle cell lymphoma after Bruton tyrosine kinase inhibitor failure in Europe: The SCHOLAR-2 retrospective chart review study
Mantle cell lymphoma (MCL) after relapse is associated with poor prognosis. No standard of care exists and available evidence for treatments is limited, particularly in patients who fail Bruton tyrosine kinase inhibitor (BTKi) therapy. This multicentre retrospective chart review study, SCHOLAR-2, addresses this knowledge gap and reports on data collected from 240 patients with relapsed/refractory MCL in Europe who were treated with BTKi-based therapy between July 2012 and July 2018, and had experienced disease progression while on BTKi therapy or discontinued BTKi therapy due to intolerance. The median overall survival (OS) from initiation of first BTKi therapy was 14.6 months (95% confidence interval [CI] 11.6–20.0) in the overall cohort, 5.5 months (95% CI 3.9–8.2) in 91 patients without post-BTKi therapy, and 23.8 months (95% CI 18.9–30.1) in 149 patients who received post-BTKi therapy (excluding chimeric antigen receptor T-cell treatment). In the latter group, patients received a median of one (range, one to seven) line of post-BTKi therapy, with lenalidomide-containing regimens and bendamustine plus rituximab being the most frequently administered; the median OS from initiation of first post-BTKi therapy was 9.7 months (95% CI 6.3–12.7). These results provide a benchmark for survival in patients with R/R MCL receiving salvage therapy after BTKi failure
Multiresolution analysis of active region magnetic structure and its correlation with the Mt. Wilson classification and flaring activity
Two different multi-resolution analyses are used to decompose the structure
of active region magnetic flux into concentrations of different size scales.
Lines separating these opposite polarity regions of flux at each size scale are
found. These lines are used as a mask on a map of the magnetic field gradient
to sample the local gradient between opposite polarity regions of given scale
sizes. It is shown that the maximum, average and standard deviation of the
magnetic flux gradient for alpha, beta, beta-gamma and beta-gamma-delta active
regions increase in the order listed, and that the order is maintained over all
length-scales. This study demonstrates that, on average, the Mt. Wilson
classification encodes the notion of activity over all length-scales in the
active region, and not just those length-scales at which the strongest flux
gradients are found. Further, it is also shown that the average gradients in
the field, and the average length-scale at which they occur, also increase in
the same order. Finally, there are significant differences in the gradient
distribution, between flaring and non-flaring active regions, which are
maintained over all length-scales. It is also shown that the average gradient
content of active regions that have large flares (GOES class 'M' and above) is
larger than that for active regions containing flares of all flare sizes; this
difference is also maintained at all length-scales.Comment: Accepted for publication in Solar Physic
Information ontrol and the exercise of power in the obstetrical encounter
Interactions between doctor and patient involve participants with unequal power and possibly different interests. While a number of studies have focused upon the doctor/patient relationship, few have examined the utility of the concept of power and its capacity to help us understand the outcome of these interactions. The information sought by pregnant women from their obstetricians is used to provide a case study of one conceptualization and test of the utility of the concept of power. Pregnant women and their obstetricians are found to have different perceptions of the information that should be exchanged during their interactions. Women generally fail to obtain the information they want. Lower social class patients desire more and obtain less information than their higher status counterparts
Differential exposure and reactivity to interpersonal stress predict sex differences in adolescent depression
This study tested the hypothesis that higher rates of depression in adolescent girls are explained by their greater exposure and reactivity to stress in the interpersonal domain in a large sample of 15-year-olds. Findings indicate that adolescent girls experienced higher levels of total and interpersonal episodic stress, whereas boys experienced higher levels of chronic stress (academic and close friendship domains). Higher rates of depression in girls were explained by their greater exposure to total stress, particularly interpersonal episodic stress. Adolescent girls were also more reactive (more likely to become depressed) to both total and interpersonal episodic stress. The findings suggest that girls experience higher levels of episodic stress and are more reactive to these stressors, increasing their likelihood of becoming depressed compared to boys. Results were discussed in terms of girls' greater interpersonal focus and implications for understanding sex differences in depression
Increasing body mass index from age 5 to 14 years predicts asthma among adolescents: evidence from a birth cohort study
Background:Obesity and asthma are common disorders, and the prevalence of both has increased in recent decades. It has been suggested that increases in the prevalence of obesity might in part explain the increase in asthma prevalence. This study aims to examine the prospective association between change in body mass index (BMI) z-score between ages 5 and 14 years and asthma symptoms at 14 years. Methods:Data was taken from the Mater University Study of Pregnancy and its outcomes (MUSP), a birth cohort of 7223 mothers and children started in Brisbane (Australia) in 1981. BMI was measured at age 5 and 14 years. Asthma was assessed from maternal reports of symptoms at age 5 and 14 years. In this study analyses were conducted on 2911 participants who had information on BMI and asthma at both ages. Results: BMI z-score at age 14 and the change in BMI z-score from age 5 to 14–years were positively associated with asthma symptoms at age 14 years, whereas BMI z-score at age 5 was not associated with asthma at age 14. Adjustment for a range of early-life exposures did not substantially alter these findings. The association between change in BMI z-score with asthma symptoms at 14 years appeared stronger for male subjects compared with female subjects but there was no statistical evidence for a sex difference (P=0.36). Conclusions: Increase in BMI z-score between age 5 and 14 years is associated with increased risk of asthma symptoms in adolescence
Prediction of Obesity in Children at 5 years: A Cohort Study
Objective To examine determinants of moderate and severe obesity in children at 5 years of age. Methodology A prospective cohort of mothers were enrolled at first antenatal visit, and interviewed shortly after delivery, at 6 months and 5 years. Detailed health, psychological and social questionnaires were completed at each phase by mothers, and child health questionnaires at 6 months and 5 years. At 5 years 4062 children were assessed physically, the Peabody Picture Vocabulary Test administered and mothers completed a modified Child Behaviour Checklist. Moderate obesity was defined as BMI between 85th and 94th percentiles inclusively, and severe obesity as a BMI greater than the 94th percentile. Results Independent predictors of severe obesity at 5 years were birthweight, female gender, maternal BMI and paternal BMI. Moderate obesity at 5 years was predicted by birthweight, paternal BMI and sleeplessness at 6 months, while small for gestational age (SGA) status and feeding problems at 6 months were protective factors for moderate obesity. Obesity was not associated with problems of language comprehension or behaviour. Conclusions Findings of this study suggest that biological rather than psychosocial factors are the major determinants of obesity at 5 years
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