22,008 research outputs found
Controlling secretion to limit chemoresistance
The tumor microenvironment influences cancer progression and therapy outcome by mechanisms not yet fully understood. In this issue, Bent et al. (2016) show how chemotherapy causes endothelial senescence. Interestingly, senescent endothelial cells do not mount a typical senescence-associated secretory phenotype but instead acutely secrete IL-6, promoting chemoresistance. This study unveils a physiological switch involving PI3K/AKT/mTOR signaling that restrains the senescence secretory responses to limit the detrimental consequences of persistent inflammation
Frequency dependence of pulsar radiation patterns
We report on new results from simultaneous, dual frequency, single pulse
observation of PSR B0329+54 using the Giant Metrewave Radio Telescope. We find
that the longitude separation of subpulses at two different frequencies (238
and 612 MHz) is less than that for the corresponding components in the average
profile. A similar behaviour has been noticed before in a number of pulsars. We
argue that subpulses are emitted within narrow flux tubes of the dipolar field
lines and that the mean pulsar beam has a conal structure. In such a model the
longitudes of profile components are determined by the intersection of the line
of sight trajectory with subpulse-associated emission beams. Thus, we show that
the difference in the frequency dependence of subpulse and profile component
longitudes is a natural property of the conal model of pulsar emission beam. We
support our conclusions by numerical modelling of pulsar emission, using the
known parameters for this pulsar, which produce results that agree very well
with our dual frequency observations.Comment: 24 pages, 8 figures. Accepted for publication in Ap
Spark Model for Pulsar Radiation Modulation Patterns
A non-stationary polar gap model first proposed by Ruderman & Sutherland
(1975) is modified and applied to spark-associated pulsar emission at radio
wave-lengths. It is argued that under physical and geometrical conditions
prevailing above pulsar polar cap, highly non-stationary spark discharges do
not occur at random positions. Instead, sparks should tend to operate in well
determined preferred regions. At any instant the polar cap is populated as
densely as possible with a number of two-dimensional sparks with a
characteristic dimension as well as a typical distance between adjacent sparks
being about the polar gap height. Our model differs, however, markedly from its
original 'hollow cone' version. The key feature is the quasi-central spark
driven by pair production process and anchored to the local pole of a
sunspot-like surface magnetic field. This fixed spark prevents the motion of
other sparks towards the pole, restricting it to slow circumferential drift
across the planes of field lines converging at the local pole. We argue that
the polar spark constitutes the core pulsar emission, and that the annular
rings of drifting sparks contribute to conal components of the pulsar beam. We
found that the number of nested cones in the beam of typical pulsar should not
excced three; a number also found by Mitra & Deshpande (1999) using a
completely different analysis.Comment: 31 pages, 8 figures, accepted by Ap
Near field and far field scattering of surface plasmon polaritons by one-dimensional surface defects
A rigorous formulation for the scattering of surface plasmon polaritons (SPP)
from a one-dimensional surface defect of any shape that yields the
electromagnetic field in the vacuum half-space above the vacuum-metal interface
is developed by the use of an impedance boundary condition. The electric and
magnetic near fields, the angular distribution of the far-field radiation into
vacuum due to SPP-photon coupling, and the SPP reflection and transmission
coefficients are calculated by numerically solving the k-space integral
equation upon which the formulation is based. In particular, we consider
Gaussian-shaped defects and study the dependence of the above mentioned
physical quantities on their 1/e half-width a and height h. SPP reflection is
significant for narrow defects; maximum reflection (plasmon mirrors) is
achieved for a~lambda/10. For increasing defect widths, protuberances and
indentations behave differently. The former give rise to a monotonic increase
of radiation at the expense of SPP transmission for increasing defect
half-width. Indentations exhibit a significant increase of radiation (decrease
of SPP transmission) for half-widths of the order of or smaller than the
wavelength, but tend to total SPP transmission in an oscillatory manner upon
further increasing the half-width. Light-emitters might thus be associated with
either wide indentations, or protuberances with widths that are of the order of
or smaller than the wavelength.Comment: REVTeX 3.1, 10 pages with 9 EPS figures (epsf macro
Global velocity field and bubbles in the BCD Mrk86
We have studied the velocity field of the Blue Compact Dwarf galaxy Mrk86
(NGC2537) using data provided by 14 long-slit optical spectra. This kinematical
information is complemented with narrow-band ([OIII]5007A and Halpha) and
broad-band (B, V, Gunn-r and K) imaging. The analysis of the galaxy global
velocity field suggests that the ionized gas could be distributed in a rotating
inclined disk, with projected central angular velocity of Omega=34 km/s/kpc.
The comparison between the stellar, HI and modeled dark matter density profile,
indicates that the total mass within its optical radius is dominated by the
stellar component. Peculiarities observed in its velocity field can be
explained by irregularities in the ionized gas distribution or local motions
induced by star formation. Kinematical evidences for two expanding bubbles,
Mrk86-B and Mrk86-C, are given. They show expanding velocities of 34 km/s and
17 km/s, Halpha luminosities of 3x10^38 erg/s and 1.7x10^39 erg/s, and physical
radii of 374 and 120 pc, respectively. The change in the [SII]/Halpha,
[NII]/Halpha, [OII]/[OIII] and [OIII]/Hbeta line ratios with the distance to
the bubble precursor suggests a diminution in the ionization parameter and, in
the case of Mrk86-B, an enhancement of the shock-excited gas emission. The
optical-near-infrared colours of the bubble precursors are characteristic of
low metallicity star forming regions (0.2 Zsun) with burst strengths of about 1
per cent in mass.Comment: 14 pages, 12 PostScript figures, accepted for publication in MNRAS,
also available at ftp://cutrex.fis.ucm.es/pub/OUT/gil/PAPERS
Asymptotic approximations to the nodes and weights of Gauss-Hermite and Gauss-Laguerre quadratures
Asymptotic approximations to the zeros of Hermite and Laguerre polynomials
are given, together with methods for obtaining the coefficients in the
expansions. These approximations can be used as a standalone method of
computation of Gaussian quadratures for high enough degrees, with Gaussian
weights computed from asymptotic approximations for the orthogonal polynomials.
We provide numerical evidence showing that for degrees greater than the
asymptotic methods are enough for a double precision accuracy computation
(- digits) of the nodes and weights of the Gauss--Hermite and
Gauss--Laguerre quadratures.Comment: Submitted to Studies in Applied Mathematic
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