3,950 research outputs found
Duality of Quasilocal Black Hole Thermodynamics
We consider T-duality of the quasilocal black hole thermodynamics for the
three-dimensional low energy effective string theory. Quasilocal thermodynamic
variables in the first law are explicitly calculated on a general axisymmetric
three-dimensional black hole solution and corresponding dual one. Physical
meaning of the dual invariance of the black hole entropy is considered in terms
of the Euclidean path integral formulation.Comment: 19 pages, Latex, no figures, to be published in Class. Quantum Grav.
Some minor changes, references adde
Pan-urologic cancer genomic subtypes that transcend tissue of origin
AbstractUrologic cancers include cancers of the bladder, kidney, prostate, and testes, with common molecular features spanning different types. Here, we show that 1954 urologic cancers can be classified into nine major genomic subtypes, on the basis of multidimensional and comprehensive molecular characterization (including DNA methylation and copy number, and RNA and protein expression). Tissue dominant effects are first removed computationally in order to define these subtypes, which reveal common processesâreflecting in part tumor microenvironmental influencesâdriving cellular behavior across tumor lineages. Six of the subtypes feature a mixture of represented cancer types as defined by tissue or cell of origin. Differences in patient survival and in the manifestation of specific pathwaysâincluding hypoxia, metabolism, NRF2-ARE, Hippo, and immune checkpointâcan further distinguish the subtypes. Immune checkpoint markers and molecular signatures of macrophages and T cell infiltrates are relatively high within distinct subsets of each cancer type studied. The pan-urologic cancer genomic subtypes would facilitate information sharing involving therapeutic implications between tissue-oriented domains.</jats:p
Design of Copolymeric Materials
We devise a method for designing materials that will have some desired
structural characteristics. We apply it to multiblock copolymers that have two
different types of monomers, A and B. We show how to determine what sequence of
A's and B's should be synthesised in order to give a particular structure and
morphology. %For example in a melt of such %polymers, one may wish to engineer
a body-centered %cubic structure. Using this method in conjunction with the
theory of microphase separation developed by Leibler, we show it is possible to
efficiently search for a desired morphology. The method is quite general and
can be extended to design isolated heteropolymers, such as proteins, with
desired structural characteristics. We show that by making certain
approximations to the exact algorithm, a method recently proposed by
Shakhnovich and Gutin is obtained. The problems with this method are discussed
and we propose an improved approximate algorithm that is computationally
efficient.Comment: 15 pages latex 2.09 and psfig, 1 postscript figure
Detecting extreme mass ratio inspirals with LISA using time-frequency methods II: search characterization
The inspirals of stellar-mass compact objects into supermassive black holes
constitute some of the most important sources for LISA. Detection of these
sources using fully coherent matched filtering is computationally intractable,
so alternative approaches are required. In a previous paper (Wen and Gair 2005,
gr-qc/0502100), we outlined a detection method based on looking for excess
power in a time-frequency spectrogram of the LISA data. The performance of the
algorithm was assessed using a single `typical' trial waveform and
approximations to the noise statistics. In this paper we present results of
Monte Carlo simulations of the search noise statistics and examine its
performance in detecting a wider range of trial waveforms. We show that typical
extreme mass ratio inspirals (EMRIs) can be detected at distances of up to 1--3
Gpc, depending on the source parameters. We also discuss some remaining issues
with the technique and possible ways in which the algorithm can be improved.Comment: 15 pages, 9 figures, to appear in proceedings of GWDAW 9, Annecy,
France, December 200
Response of the Brazilian gravitational wave detector to signals from a black hole ringdown
It is assumed that a black hole can be disturbed in such a way that a
ringdown gravitational wave would be generated. This ringdown waveform is well
understood and is modelled as an exponentially damped sinusoid. In this work we
use this kind of waveform to study the performance of the SCHENBERG
gravitational wave detector. This first realistic simulation will help us to
develop strategies for the signal analysis of this Brazilian detector. We
calculated the signal-to-noise ratio as a function of frequency for the
simulated signals and obtained results that show that SCHENBERG is expected to
be sensitive enough to detect this kind of signal up to a distance of .Comment: 5 pages, 4 figures, Amaldi 5 Conference Proceedings contribution.
Submitted to Class. Quantum Gra
An excess power statistic for detection of burst sources of gravitational radiation
We examine the properties of an excess power method to detect gravitational
waves in interferometric detector data. This method is designed to detect
short-duration (< 0.5 s) burst signals of unknown waveform, such as those from
supernovae or black hole mergers. If only the bursts' duration and frequency
band are known, the method is an optimal detection strategy in both Bayesian
and frequentist senses. It consists of summing the data power over the known
time interval and frequency band of the burst. If the detector noise is
stationary and Gaussian, this sum is distributed as a chi-squared (non-central
chi-squared) deviate in the absence (presence) of a signal. One can use these
distributions to compute frequentist detection thresholds for the measured
power. We derive the method from Bayesian analyses and show how to compute
Bayesian thresholds. More generically, when only upper and/or lower bounds on
the bursts duration and frequency band are known, one must search for excess
power in all concordant durations and bands. Two search schemes are presented
and their computational efficiencies are compared. We find that given
reasonable constraints on the effective duration and bandwidth of signals, the
excess power search can be performed on a single workstation. Furthermore, the
method can be almost as efficient as matched filtering when a large template
bank is required. Finally, we derive generalizations of the method to a network
of several interferometers under the assumption of Gaussian noise.Comment: 22 pages, 6 figure
Parallelization of Markov chain generation and its application to the multicanonical method
We develop a simple algorithm to parallelize generation processes of Markov
chains. In this algorithm, multiple Markov chains are generated in parallel and
jointed together to make a longer Markov chain. The joints between the
constituent Markov chains are processed using the detailed balance. We apply
the parallelization algorithm to multicanonical calculations of the
two-dimensional Ising model and demonstrate accurate estimation of
multicanonical weights.Comment: 15 pages, 5 figures, uses elsart.cl
The nature of the different zero-temperature phases in discrete two-dimensional spin glasses: Entropy, universality, chaos and cascades in the renormalization group flow
The properties of discrete two-dimensional spin glasses depend strongly on
the way the zero-temperature limit is taken. We discuss this phenomenon in the
context of the Migdal-Kadanoff renormalization group. We see, in particular,
how these properties are connected with the presence of a cascade of fixed
points in the renormalization group flow. Of particular interest are two
unstable fixed points that correspond to two different spin-glass phases at
zero temperature. We discuss how these phenomena are related with the presence
of entropy fluctuations and temperature chaos, and universality in this model.Comment: 14 pages, 5 figures, 2 table
Sequence Dependence of Self-Interacting Random Chains
We study the thermodynamic behavior of the random chain model proposed by
Iori, Marinari and Parisi, and how this depends on the actual sequence of
interactions along the chain. The properties of randomly chosen sequences are
compared to those of designed ones, obtained through a simulated annealing
procedure in sequence space. We show that the transition to the folded phase
takes place at a smaller strength of the quenched disorder for designed
sequences. As a result, folding can be relatively fast for these sequences.Comment: 14 pages, uuencoded compressed postscript fil
Note and Comment
A Criticism of President Hadley\u27s Views on The constitutional Position of Property in America ; Inconsistent Defenses; Vacation of Corporation Directors; Right of the United States to Recover Money Paid on Pension Checks Bearing Forged Indorsements; Damages Recoverable on Stock Broker\u27s Failure to Purchase as Directed
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