Serological survey of anti-group A rotavirus IgM in UK adults

Rotaviral associated disease of infants in the UK is seasonal and infection in adults not uncommon but the relationship between these has been little explored. Adult sera collected monthly for one year from routine hospital samples were screened for the presence of anti-group A rotavirus immunoglobulin M class antibodies as a marker of recent infection. Anti-rotavirus IgM was seen in all age groups throughout the year with little obvious seasonal variation in the distribution of antibody levels. IgM concentrations and the proportion seropositive above a threshold both increased with age with high concentrations consistently observed in the elderly. Results suggest either high infection rates of rotavirus in adults, irrespective of seasonal disease incidence in infants, IgM persistence or IgM cross-reactivity. These results support recent evidence of differences between infant and adult rotavirus epidemiology and highlight the need for more extensive surveys to investigate age and time related infection and transmission of rotavirus

Brownian ratchets driven by asymmetric nucleation of hydrolysis waves

We propose a stochastic process wherein molecular transport is mediated by asymmetric nucleation of domains on a one-dimensional substrate. Track-driven mechanisms of molecular transport arise in biophysical applications such as Holliday junction positioning and collagenase processivity. In contrast to molecular motors that hydrolyze nucleotide triphosphates and undergo a local molecular conformational change, we show that asymmetric nucleation of hydrolysis waves on a track can also result in directed motion of an attached particle. Asymmetrically cooperative kinetics between ``hydrolyzed'' and ``unhydrolyzed'' states on each lattice site generate moving domain walls that push a particle sitting on the track. We use a novel fluctuating-frame, finite-segment mean field theory to accurately compute steady-state velocities of the driven particle and to discover parameter regimes which yield maximal domain wall flux, leading to optimal particle drift.Comment: 5 pp, 6 fig

The southern dust pillars of the Carina Nebula

We present preliminary results from a detailed study towards four previously detected bright mid-infrared sources in the southern part of the Carina Nebula: G287.73--0.92, G287.84--0.82, G287.93--0.99 and G288.07--0.80. All of these sources are located at the heads of giant dust pillars that point towards the nearby massive star cluster, Trumpler 16. It is unclear if these pillars are the prime sites for a new generation of triggered star formation or if instead they are the only remaining parts of the nebula where ongoing star fromation can take place.Comment: 2 pages, to appear in the proceedings of "Hot Star Workshop III: The Earliest Phases of Massive Star Birth" (ed. P.A. Crowther

Anomalous aging phenomena caused by drift velocities

We demonstrate via several examples that a uniform drift velocity gives rise to anomalous aging, characterized by a specific form for the two-time correlation functions, in a variety of statistical-mechanical systems far from equilibrium. Our first example concerns the oscillatory phase observed recently in a model of competitive learning. Further examples, where the proposed theory is exact, include the voter model and the Ohta-Jasnow-Kawasaki theory for domain growth in any dimension, and a theory for the smoothing of sandpile surfaces.Comment: 7 pages, 3 figures. To appear in Europhysics Letter

Models of competitive learning: complex dynamics, intermittent conversions and oscillatory coarsening

We present two models of competitive learning, which are respectively interfacial and cooperative learning. This learning is outcome-related, so that spatially and temporally local environments influence the conversion of a given site between one of two different types. We focus here on the behavior of the models at coexistence, which yields new critical behavior and the existence of a phase involving a novel type of coarsening which is oscillatory in nature.Comment: 23 pages, 11 figures. To appear in Phys. Rev.

A survey for PAH emission in H II regions, planetary and proto-planetary nebulae

The results of a systematic investigation of polycyclic aromatic hydrocarbon (PAH) emission in H II regions, planetary nebulae (PN), and proto-planetary nebulae (PNN), are reported. Data is obtained from the low resolution spectra (LRS) of IRAS. The results show that: PAHs are formed in carbon rich objects; and PAH emission is ubiquitous in general interstellar medium and requires the presence of ultraviolet photons, in planetary and proto-planetary nebulae, PAH emission is seen only where an ionizing flux is present and in carbon rich objects

Finite element optimizations for efficient non-linear electrical tomography reconstruction

Electrical Tomography can produce accurate results only if the underlying 2D or 3D volume discretization is chosen suitably for the applied numerical algorithm. We give general indications where and how to optimize a finite element discretization of a volume under investigation to enable efficient computation of potential distributions and the reconstruction of materials. For this, we present an error estimator and material-gradient indicator as a driver for adaptive mesh refinement and show how finite element mesh properties affect the efficiency and accuracy of the solutions