960 research outputs found

    Potential implications of coronary artery calcium testing for guiding aspirin use among asymptomatic individuals with diabetes.

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    ObjectiveIt is unclear whether coronary artery calcium (CAC) is effective for risk stratifying patients with diabetes in whom treatment decisions are uncertain.Research design and methodsOf 44,052 asymptomatic individuals referred for CAC testing, we studied 2,384 individuals with diabetes. Subjects were followed for a mean of 5.6 Ā± 2.6 years for the end point of all-cause mortality.ResultsThere were 162 deaths (6.8%) in the population. CAC was a strong predictor of mortality across age-groups (age <50, 50-59, ā‰„60), sex, and risk factor burden (0 vs. ā‰„1 additional risk factor). In individuals without a clear indication for aspirin per current guidelines, CAC stratified risk, identifying patients above and below the 10% risk threshold of presumed aspirin benefit.ConclusionsCAC can help risk stratify individuals with diabetes and may aid in selection of patients who may benefit from therapies such as low-dose aspirin for primary prevention

    More Evidence for a Distribution of Tunnel Splittings in Mn12_{12}-acetate

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    In magnetic fields applied parallel to the anisotropy axis, the magnetization of Mn12_{12} has been measured in response to a field that is swept back and forth across the resonances corresponding to steps N=4,5,...9N=4,5,...9. The fraction of molecules remaining in the metastable well after each sweep through the resonance is inconsistent with expectations for an ensemble of identical molecules. The data are consistent instead with the presence of a broad distribution of tunnel splittings. A very good fit is obtained for a Gaussian distribution of the second-order anisotropy tunneling parameter XE=āˆ’lnā”(āˆ£Eāˆ£/2D)X_E=-\ln(\mid E\mid/2D). We show that dipolar shuffling is a negligible effect which cannot explain our data.Comment: minor corrections (PACS nos, signs in Fig. 2

    Non-equilibrium Magnetization Dynamics in the Fe_8 Single-Molecule Magnet Induced by High-Intensity Microwave Radiation

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    Resonant microwave radiation applied to a single crystal of the molecular magnet Fe_8 induces dramatic changes in the sample's magnetization. Transitions between excited states are found even though at the nominal system temperature these levels have negligible population. We find evidence that the sample heats significantly when the resonance condition is met. In addition, heating is observed after a short pulse of intense radiation has been turned off, indicating that the spin system is out of equilibrium with the lattice.Comment: Version to appear in Europhysics Letters. Minor changes and updated reference

    Radiation- and Phonon-Bottleneck-Induced Tunneling in the Fe8 Single-Molecule Magnet

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    We measure magnetization changes in a single crystal of the single-molecule magnet Fe8 when exposed to intense, short (<20 Ī¼\mus) pulses of microwave radiation resonant with the m = 10 to 9 transition. We find that radiation induces a phonon bottleneck in the system with a time scale of ~5 Ī¼\mus. The phonon bottleneck, in turn, drives the spin dynamics, allowing observation of thermally assisted resonant tunneling between spin states at the 100-ns time scale. Detailed numerical simulations quantitatively reproduce the data and yield a spin-phonon relaxation time of T1 ~ 40 ns.Comment: 6 RevTeX pages, including 4 EPS figures, version accepted for publicatio

    Experimental Upper Bound on Superradiance Emission from Mn12 Acetate

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    We used a Josephson junction as a radiation detector to look for evidence of the emission of electromagnetic radiation during magnetization avalanches in a crystal assembly of Mn_12-Acetate. The crystal assembly exhibits avalanches at several magnetic fields in the temperature range from 1.8 to 2.6 K with durations of the order of 1 ms. Although a recent study shows evidence of electromagnetic radiation bursts during these avalanches [J. Tejada, et al., Appl. Phys. Lett. {\bf 84}, 2373 (2004)], we were unable to detect any significant radiation at well-defined frequencies. A control experiment with external radiation pulses allows us to determine that the energy released as radiation during an avalanche is less than 1 part in 10^4 of the total energy released. In addition, our avalanche data indicates that the magnetization reversal process does not occur uniformly throughout the sample.Comment: 4 RevTeX pages, 3 eps figure

    Abrupt Transition between Thermally-Activated Relaxation and Quantum Tunneling in a Molecular Magnet

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    We report Hall sensor measurements of the magnetic relaxation of Mn12_{12} acetate as a function of magnetic field applied along the easy axis of magnetization. Data taken at a series of closely-spaced temperatures between 0.24 K and 1.4 K provide strong new evidence for an abrupt ``first-order'' transition between thermally-assisted relaxation and magnetic decay via quantum tunneling.Comment: 4 pages, including 7 figure
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