Perbedaan House Indeks (HI) Berdasarkan Stratifikasi Daerah DBD di Wilayah Kerja UPT Puskesmas Martapura Kecamatan Martapura Kota Tahun 2012

Demam Berdarah Dengue (DBD) disebabkan oleh virus dan disebarkan oleh nyamuk. Penyakit ini adalah salah satu masalah bagi kesehatan masyarakat Indonesia yang cenderung terus menyebar dengan meningkatnya mobilitas dan kepadatan populasi. Dari tahun 2009 sampai dengan 2011 kasus DBD selalu ditemukan di wilayah kerja Puskesmas Martapura. Jika dilihat dari stratifikasi kasus DBD per kelurahan/desa tahun 2012, terdapat 1 kelurahan dan 3 desa yang termasuk dalam kategori daerah endemis DBD serta 7 desa yang termasuk dalam kategori daerah sporadis DBD. Belum pernah dilakukan pemeriksaan House Indeks (HI) oleh petugas P2DBD Puskesmas Martapura dan Dinas Kesehatan Kabupaten Banjar di wilayah kerja Puskesmas Martapura. Penelitian ini merupakan penelitian observasional analitik untuk mengetahui perbedaan HI daerah endemis DBD dengan daerah sporadis DBD di wilayah kerja UPT Puskesmas Martapura. Subjek penelitian adalah HI daerah endemis dan sporadis yang diuji dengan uji statistik Independent 2-samples t-test. Hasil menunjukkan bahwa tidak ada perbedaan HI antara daerah endemik dan sporadis dengue di wilayah kerja Puskesmas Martapura pada tahun 2012

More accurate process understanding from process characterization studies using Monte Carlo simulation, regularized regression, and classification models

Establishment of an appropriate control strategy with defined operating ranges (OR) predicted to meet a target product profile is a critical component of commercializing new biologics under the Quality by Design (QbD) approach. Process characterization (PC) studies are performed to expand process understanding by achieving two main goals: 1) determining which process parameters have significant effects on quality attributes and 2) establishing models describing the relationships between these critical process parameters (CPP) and critical quality attributes (CQA). Risk assessment and design of experiments (DOE) techniques are effectively deployed in the industry to identify parameters to study and build process understanding. However, the true value of the data produced by these studies can be compromised by the inherent flaws with traditional data analysis techniques. In particular, p-value based methods such as stepwise regression are prone to generate false positives and overestimated parameter coefficients. Many of the deficiencies of traditional stepwise regression can be alleviated by applying Monte Carlo cross validation (MCCV) and simulations to stepwise algorithms. These methods can greatly enhance process understanding and assist in the selection of CPPs. Regularized regression methods such as LASSO, ridge, and elastic net are also designed to overcome many of the issues inherent in techniques based on ordinary least squares. However, a superior strategy is to build multiple models using a variety of techniques and use the insights gained from each to establish the relationships between CPPs and CQAs. Use of complementary methods during data analysis allows more informed decisions to be made during model construction. Please click Additional Files below to see the full abstract

Suppression of Kondo effect in a quantum dot by external irradiation

We demonstrate that the external irradiation brings decoherence in the spin states of the quantum dot. This effect cuts off the Kondo anomaly in conductance even at zero temperature. We evaluate the dependence of the DC conductance in the Kondo regime on the power of irradiation, this dependence being determined by the decoherence.Comment: 4 pages, 1 figur

Nonlinear Response of a Kondo system: Direct and Alternating Tunneling Currents

Non - equilibrium tunneling current of an Anderson impurity system subject to both constant and alternating electric fields is studied. A time - dependent Schrieffer - Wolff transformation maps the time - dependent Anderson Hamiltonian onto a Kondo one. Perturbation expansion in powers of the Kondo coupling strength is carried out up to third order, yielding a remarkably simple analytical expression for the tunneling current. It is found that the zero - bias anomaly is suppressed by an ac - field. Both dc and the first harmonic are equally enhanced by the Kondo effect, while the higher harmonics are relatively small. These results are shown to be valid also below the Kondo temperature.Comment: 7 pages, RevTeX, 3 PS figures attached, the article has been significantly developed: time - dependent Schrieffer - Wolff transformation is presented in the full form, the results are applied to the change in the direct current induced by an alternating field (2 figures are new

Determination of the complex microwave photoconductance of a single quantum dot

A small quantum dot containing approximately 20 electrons is realized in a two-dimensional electron system of an AlGaAs/GaAs heterostructure. Conventional transport and microwave spectroscopy reveal the dot's electronic structure. By applying a coherently coupled two-source technique, we are able to determine the complex microwave induced tunnel current. The amplitude of this photoconductance resolves photon-assisted tunneling (PAT) in the non-linear regime through the ground state and an excited state as well. The out-of-phase component (susceptance) allows to study charge relaxation within the quantum dot on a time scale comparable to the microwave beat period.Comment: 5.5 pages, 6 figures, accepted by Phys. Rev. B (Jan. B15 2001

Resonant Photon-Assisted Tunneling Through a Double Quantum Dot: An Electron Pump From Spatial Rabi Oscillations

The time average of the fully nonlinear current through a double quantum dot, subject to an arbitrary combination of ac and dc voltages, is calculated exactly using the Keldysh nonequilibrium Green function technique. When driven on resonance, the system functions as an efficient electron pump due to Rabi oscillation between the dots. The pumping current is maximum when the coupling to the leads equals the Rabi frequency.Comment: 6 pages, REVTEX 3.0, 3 postscript figure

Electronic and Magnetic Properties of Partially-Open Carbon Nanotubes

On the basis of the spin-polarized density functional theory calculations, we demonstrate that partially-open carbon nanotubes (CNTs) observed in recent experiments have rich electronic and magnetic properties which depend on the degree of the opening. A partially-open armchair CNT is converted from a metal to a semiconductor, and then to a spin-polarized semiconductor by increasing the length of the opening on the wall. Spin-polarized states become increasingly more stable than nonmagnetic states as the length of the opening is further increased. In addition, external electric fields or chemical modifications are usable to control the electronic and magnetic properties of the system. We show that half-metallicity may be achieved and the spin current may be controlled by external electric fields or by asymmetric functionalization of the edges of the opening. Our findings suggest that partially-open CNTs may offer unique opportunities for the future development of nanoscale electronics and spintronics.Comment: 6 figures, to appear in J. Am. Chem. So

Concordance between SIVA, IVAN, and VAMPIRE software tools for semi-automated analysis of retinal vessel caliber

We aimed to compare measurements from three of the most widely used software packages in the literature and to generate conversion algorithms for measurement of the central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE) between SIVA and IVAN and between SIVA and VAMPIRE. We analyzed 223 retinal photographs from 133 human participants using both SIVA, VAMPIRE and IVAN independently for computing CRAE and CRVE. Agreement between measurements was assessed using Bland–Altman plots and intra-class correlation coefficients. A conversion algorithm between measurements was carried out using linear regression, and validated using bootstrapping and root-mean-square error. The agreement between VAMPIRE and IVAN was poor to moderate: The mean difference was 20.2 µm (95% limits of agreement, LOA, −12.2–52.6 µm) for CRAE and 21.0 µm (95% LOA, −17.5–59.5 µm) for CRVE. The agreement between VAMPIRE and SIVA was also poor to moderate: the mean difference was 36.6 µm (95% LOA, −12.8–60.4 µm) for CRAE, and 40.3 µm (95% LOA, 5.6–75.0 µm) for CRVE. The agreement between IVAN and SIVA was good to excellent: the mean difference was 16.4 µm (95% LOA, −4.25–37.0 µm) for CRAE, and 19.3 µm (95% LOA, 0.09–38.6 µm) for CRVE. We propose an algorithm converting IVAN and VAMPIRE measurements into SIVA-estimated measurements, which could be used to homogenize sets of vessel measurements obtained with different software packages

Singularities, Lax degeneracies and Maslov indices of the periodic Toda chain

The n-particle periodic Toda chain is a well known example of an integrable but nonseparable Hamiltonian system in R^{2n}. We show that Sigma_k, the k-fold singularities of the Toda chain, ie points where there exist k independent linear relations amongst the gradients of the integrals of motion, coincide with points where there are k (doubly) degenerate eigenvalues of representatives L and Lbar of the two inequivalent classes of Lax matrices (corresponding to degenerate periodic or antiperiodic solutions of the associated second-order difference equation). The singularities are shown to be nondegenerate, so that Sigma_k is a codimension-2k symplectic submanifold. Sigma_k is shown to be of elliptic type, and the frequencies of transverse oscillations under Hamiltonians which fix Sigma_k are computed in terms of spectral data of the Lax matrices. If mu(C) is the (even) Maslov index of a closed curve C in the regular component of R^{2n}, then (-1)^{\mu(C)/2} is given by the product of the holonomies (equal to +/- 1) of the even- (or odd-) indexed eigenvector bundles of L and Lmat.Comment: 25 pages; published versio