The management and organization of philanthropy: New directions and contested undercurrents

The case for theoretical scrutiny of philanthropy's achievements and problems, in the institutional settings in which it operates, has never been stronger. In this introduction to IJMR’s special issue on philanthropy, we examine the developing levels and directions of institutional philanthropy scholarship, together with the consensual and contradictory themes they exemplify and the theoretical leads to which they give rise. Modern philanthropic theory is still largely based on archetypes developed in the early 20th century that accord a central role to foundations in addressing social challenges, yet the complex health, education and social service fields within which philanthropy operates have changed dramatically. We argue for the elevation of, and deepening directions for, theoretical study of institutional philanthropy. At present, institutional philanthropy has a modest theoretical literature, at the same time as we can notice an extensive and growing grey literature in the philanthropic community, often grounded in traditional strategic management. We reflect on the grey literature's potential development into theoretical scholarship, drawing on and fusing with a broader range of academic disciplines and organizational theories, and the linked study of the field as a discourse community. Here, the challenges of visibility and transparency in relation to privacy are significant, whether for accountability or research access

p53 mutations in urinary bladder cancer

We have screened for mutations in exons 5–8 of the p53 gene in a series consisting of 189 patients with urinary bladder neoplasms. 82 (44%) neoplasms were lowly malignant (Ta, G1–G2a) and 106 (56%) were highly malignant (G2b–G4 or ≥T1). Only one mutation was in a lowly malignant urinary bladder neoplasm, in total we found p53 mutations in 26 (14%) of the 189 patients. 30% of the samples had loss of heterozygosity (LOH) for one or both of the p53 exogenic (CA)n repeat and the p53 intragenic (AAAAT)n repeat markers. 31 samples (21%) showed LOH but were not mutated, suggesting other mechanisms inactivating p53 than mutations. 4 mutations were found at codon 280 and 2 mutations were found at codon 285, 2 previously reported hot spots for urinary bladder cancer. The study indicate a boundary between G2a and G2b tumours concerning the occurrence of genetic events affecting p53 function; moderately differentiated (G2) urinary bladder neoplasms probably are genetically heterogeneous which supports the suggestion that they should not be grouped together but instead, for example, be categorized as either lowly or highly malignant. © 2001 Cancer Research Campaign http://www.bjcancer.co

Renal Morphology, Clinical Findings, and Progression Rate in Mesoamerican Nephropathy

BackgroundMesoamerican nephropathy (MeN) is a chronic kidney disease affecting rural inhabitants in Central America. We have previously described the renal morphology in 8 patients from El Salvador. To confirm the renal pathology, we have studied kidney biopsies from patients with MeN in Nicaragua. Follow-up urine and blood samples from both biopsy studies were collected to investigate the natural history