11 research outputs found
Lectin activities of cytokines and growth factors: function and implications for pathology
The discovery that certain cytokines have
carbohydrate-binding (lectin) properties opens new
concepts in the understanding of their mechanism of
action. The carbohydrate-recognition domain, which is
localized opposite to the receptor-binding domain,
makes these molecules bi-functional. The expression of
the biological activity of the cytokine relies on its
carbohydrate-binding activity which allows the
association of the cytokine receptor with molecular
complexes comprising the specific kinase involved in
receptor phosphorylation and in specific signal
transduction. It is expected that blood accumulation of
free or membrane-bound glycan ligands of cytokines
may dramatically perturb their endogenous function
inducing specific immunodeficiencies