Effects of Castration Upon the Morphology of the Accessory Sex Organs of the Male Rat - A Scanning Electron Microscopy Study

A systematic, comparative study of the accessory sex glands of the adult male rat after androgen withdrawal was carried out. The changes were investigated by using scanning electron microscopy at different intervals after surgical castration. The main common signs of epithelial cell involution were flattening of the cell surface, reduction of the size and number of microvilli, some blurring of the cell borders, cessation of secretory activity and diminution of the luminal volume of the glands. Overall, confident signs of atrophy were evident after one week, and complete epithelial involution was reached by the third week. The epithelial cell atrophy was accompanied by a relative stromal hyperplasia. The new observation seems to be that the process of stroma consolidation is progressing for a considerable time subsequent to the completion of the epithelial involution. This phenomenon is particularly evident in the dorsal prostate, the seminal vesicle and the coagulating gland

Scanning Electron Microscopy of the Accessory Sex Glands of the Adult Male Rat

This study describes the morphology of the accessory sex glands of the adult male rat as observed by scanning electron microscopy (SEM). The purpose was to obtain a systematic and comparative SEM description of these glands and to evaluate different preparation techniques. A common morphological feature is polyhedral delineation of the cells, which exhibited a variable convexity of their apical surface. The cell apices were more or less studded with microvilli. Nevertheless, it was possible to distinguish the glands by their surface morphology. In the ventral prostate, there was a considerable heterogeneity in cell surface appearance. The lateral lobe bad a characteristic brush border, and in the dorsal lobe, surface blebbing and intracellular cisternae were observed. The cells of the seminal vesicle were covered by long microvilli, while particularly distinct, elevated cell borders and intracellular cisternae were typical for the coagulating gland. The secretory mechanism was merocrine in the ventral and lateral prostate and the seminal vesicle, and was mainly apocrine in the dorsal prostate. Surprisingly, only merocrine secretion was obvious in the coagulating gland. The most controversial observation, which needs further investigation, was the discovery of large orifices in the apical surface of individual seminal vesicle cells. These orifices may be indicative of an additional apocrine secretion in this gland. In studying this organ system, SEM provides in-formation that adds to previous transmission electron microscopical investigations

Impact of gastroesophageal reflux disease on work absenteeism, presenteeism and productivity in daily life: a European observational study

<p>Abstract</p> <p>Background</p> <p>The RANGE (<it>R</it>etrospective <it>AN</it>alysis of <it>G</it>astro<it>E</it>sophageal reflux disease [GERD]) study assessed differences among patients consulting a primary care physician due to GERD-related reasons in terms of: symptoms, diagnosis and management, response to treatment, and effects on productivity, costs and health-related quality of life. This subanalysis of RANGE determined the impact of GERD on productivity in work and daily life.</p> <p>Methods</p> <p>RANGE was conducted at 134 primary care sites across six European countries (Germany, Greece, Norway, Spain, Sweden and the UK). All subjects (aged ≥18 years) who consulted with their primary care physician over a 4-month identification period were screened retrospectively, and those consulting at least once for GERD-related reasons were identified (index visit). From this population, a random sample was selected to enter the study and attended a follow-up appointment, during which the impact of GERD on productivity while working (absenteeism and presenteeism) and in daily life was evaluated using the self-reported Work Productivity and Activity Impairment Questionnaire for patients with GERD (WPAI-GERD).</p> <p>Results</p> <p>Overall, 373,610 subjects consulted with their primary care physician over the 4-month identification period, 12,815 for GERD-related reasons (3.4%); 2678 randomly selected patients attended the follow-up appointment. Average absenteeism due to GERD was highest in Germany (3.2 hours/week) and lowest in the UK (0.4 hours/week), with an average of up to 6.7 additional hours/week lost due to presenteeism in Norway. The average monetary impact of GERD-related work absenteeism and presenteeism were substantial in all countries (from €55/week per employed patient in the UK to €273/patient in Sweden). Reductions in productivity in daily life of up to 26% were observed across the European countries.</p> <p>Conclusion</p> <p>GERD places a significant burden on primary care patients, in terms of work absenteeism and presenteeism and in daily life. The resulting costs to the local economy may be substantial. Improved management of GERD could be expected to lessen the impact of GERD on productivity and reduce costs.</p

Modelling the impact of wildfire smoke on driving speed

Traffic models can be used to study evacuation scenarios during wildland-urban interface fires and identify the ability of a community to reach a safe place. In those scenarios, wildfire smoke can reduce visibility conditions on the road. This can have serious implications on the evacuation effectiveness since drivers would reduce their speed in relation to the optical density on the road. To date, there is no traffic model which explicitly represents the impact of reduced visibility conditions on traffic evacuation flow. This paper makes use of an experimental dataset collected in a virtual reality environment to calibrate two widely used macroscopic traffic models (the Lighthill-Whitham-Richards and the Van Aerde models) in order to account for the impact of reduced visibility conditions on driving speed. An application of the calibrated traffic model considering the impact of smoke has been performed using the WUI-NITY platform, an open multi-physics platform which includes wildfire spread, pedestrian response and traffic modelling. A dedicated verification test has been developed and performed considering different values of optical densities of smoke and traffic densities to ensure the model has been implemented correctly in WUI-NITY. A case study that demonstrates the applicability of the model to real life scenarios was also implemented, based on data from an evacuation drill. This paper shows that the presence of smoke on the road can significantly decrease movement speed and increase evacuation times thus highlighting the need for inclusion of this factor in traffic evacuation models applied for wildland-urban interface fire scenarios

The students' voice: Strengths and weaknesses of an undergraduate medical curriculum in a developing country, a qualitative study

<p>Abstract</p> <p>Background</p> <p>In medical education, feedback from students' is essential in course evaluation and development. Students at Faculty of Medicine, University of Colombo, Sri Lanka complete a five year medical curriculum comprising of five different streams. We aimed to evaluate the five year medical curriculum at the Faculty of Medicine, University of Colombo, Sri Lanka.</p> <p>Methods</p> <p>A qualitative research was conducted among recent graduates of the faculty. Students' opinions on strengths and weaknesses of the curriculum were collected via questionnaires, which were analysed and classified into common themes. A focus group discussion (FGD) based on these themes was conducted among two student groups, each comprising of a facilitator, two observers and nine students selected as a representative sample from questionnaire respondents. FGDs were conducted using a semi-structured set of open-ended questions to guide participants and maintain consistency between groups. The FGD evaluated the reasons behind students' perceptions, attitudes, emotions and perceived solution. Verbal and non-verbal responses were transcribed and analysed.</p> <p>Results</p> <p>Questionnaire response rate was 82% (153/186). Students highlighted 68 and 135 different responses on strengths and weaknesses respectively. After analysis of both questionnaire and FGD results the following themes emerged: a well organized module system, increased frequency of assessments, a good variety in clinical appointments, lack of specific objectives and assessments at clinical appointments, community and behavioural sciences streams beneficial but too much time allocation, lengthy duration of course, inadequate knowledge provided on pharmacology and pathology.</p> <p>Conclusion</p> <p>We demonstrate how a brief qualitative method could be efficiently used to evaluate a curriculum spanning a considerable length of time. This method provided an insight into the students' attitudes and perceptions of the present faculty curriculum. Qualitative feedback from students highlighted certain key areas that need attention and also possible solutions as perceived by the students'.</p

Three-dimensional food printing: Its readiness for a food and nutrition insecure world

Three-dimensional (3D) food printing is a rapidly emerging technology offering unprecedented potential for customised food design and personalised nutrition. Here, we evaluate the technological advances in extrusion-based 3D food printing and its possibilities to promote healthy and sustainable eating. We consider the challenges in implementing the technology in real-world applications. We propose viable applications for 3D food printing in health care, health promotion and food waste upcycling. Finally, we outline future work on 3D food printing in food safety, acceptability and economics, ethics and regulations. .

Is impaired energy regulation the core of the metabolic syndrome in various ethnic groups of the USA and Taiwan?

<p>Abstract</p> <p>Background</p> <p>The metabolic syndrome (MetS) concept is widely used in public health and clinical settings without an agreed pathophysiology. We have re-examined the MetS in terms of body fuels, so as to provide a coherent cross-cultural pathogenesis.</p> <p>Methods</p> <p>National Health and Nutrition Examination Survey (NHANES 2001-2) with n = 2254 and Taiwanese National Health Interview Survey (NHIS) sub-set for hypertension, hyperglycemia and hyperlipidemia assessment (TwSHHH 2002), n = 5786, were used to compare different ethnicities according to NCEP-ATPIII (NCEP-tw) criteria for METS. Exploratory factor analysis (EFA) using principal components (PC) was employed to differentiate and unify MetS components across four ethnicities, gender, age-strata, and urban-rural settings.</p> <p>Results</p> <p>The first two factors from the PC analysis (PCA) accounted for from 55.2% (non-Hispanic white) to 63.7% (Taiwanese) of the variance. Rotated factor loadings showed that the six MetS components provided three clusters: the impaired energy regulation (IER) components (waist circumference, WC, fasting triglycerides, TG, and fasting plasma glucose, FPG), systolic and diastolic blood pressures (BPs), and HDL-cholesterol, where the IER components accounted for 25-26% of total variance of MetS components. For the three US ethnic subgroups, factor 1 was mainly determined by IER and HDL-cholesterol, and factor 2 was related to the BP components. For Taiwanese, IER was determinant for both factors, and BPs and HDL-cholesterol were related to factors 1 and 2 respectively.</p> <p>Conclusions</p> <p>There is a MetS core which unifies populations. It comprises WC, TG and FPG as a core, IER, which may be expressed and modulated in various second order ways.</p

The simulation of wildland-urban interface fire evacuation: The WUI-NITY platform

Wildfires are a significant safety risk to populations adjacent to wildland areas, known as the wildland-urban interface (WUI). This paper introduces a modelling platform called WUI-NITY. The platform is built on the Unity3D game engine and simulates and visualises human behaviour and wildfire spread during an evacuation of WUI communities. The purpose of this platform is to enhance the situational awareness of responders and residents during evacuation scenarios by providing information on the dynamic evolution of the emergency. WUI-NITY represents current and predicted conditions by coupling the three key modelling layers of wildfire evacuation, namely the fire, pedestrian, and traffic movement. This allows predictions of evacuation behaviour over time. The current version of WUI-NITY demonstrates the feasibility and advantages of coupling the modelling layers. Its wildfire modelling layer is based on FARSITE, the pedestrian layer implements a dedicated pedestrian response and movement model, and the traffic layer includes a traffic evacuation model based on the Lighthill-Whitham-Richards model. The platform also includes a sub-model called PERIL that designs the spatial location of trigger buffers. The main contribution of this work is in the development of a modular and model-agnostic (i.e., not linked to a specific model) platform with consistent levels of granularity (allowing a comparable modelling resolution in the representation of each layer) in all three modelling layers. WUI-NITY is a powerful tool to protect against wildfires; it can enable education and training of communities, forensic studies of past evacuations and dynamic vulnerability assessment of ongoing emergencies