255 research outputs found

    Burnout Among Postsecondary Faculty In North Dakota

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    The purpose of this study was to identify burnout levels of full-time faculty holding rank of assistant, associate, or full professor in three categories of institutions in North Dakota. The three categories comprised eight North Dakota public colleges and universities. Specifically the research questions were: (1) What level of burnout exists among full-time, postsecondary faculty? (2) Are there differences in burnout levels by rank among full-time, postsecondary faculty? (3) Are there differences in burnout levels of full-time faculty members by category of institution? (4) Are there differences in burnout levels by certain demographic variables? After a telephone pre-contact was made to solicit participation, a cover letter, demographic data sheet, and the Maslach Burnout Inventory-Educators Survey (MBI-ES) were sent to 350 faculty members in the North Dakota University System. Three hundred thirty-six responses (or 96%) were returned. Of these, 306 (or 87%) were complete and usable. Data analysis included descriptive and inferential statistics. The One-Way Analysis of Variance technique and the Tukey\u27s procedure were run. As a group, the North Dakota sample were found to have a significantly higher burnout level on all three of the MBI-ES sub-scales (Emotional Exhaustion, Depersonalization, and Personal Accomplishment) than the national average. Associate professors had a significantly higher Depersonalization score than full and assistant professors. No statistically significant differences in burnout levels were found by category of institution. Significant differences in burnout levels by age, highest degree, and perceived pressure to engage in publishing or creative production occurred. Faculty age group 40–49 had a significantly higher Emotional Exhaustion and Depersonalization score than age group over 50. Faculty with doctoral degrees were significantly lower in their Personal Accomplishment score than those with masters degrees. Finally, faculty who indicated that they felt pressure to be involved in scholarly activity had a significantly higher score on Emotional Exhaustion than those who reported no pressure

    Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the α6 subtype

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    Direct comparison of pyridine versus pyrimidine substituents on a small but diverse set of ligands indicates that the pyrimidine substitution has the potential to enhance affinity and/or functional activity at α6 subunit-containing neuronal nicotinic receptors (NNRs) and decrease activation of ganglionic nicotinic receptors, depending on the scaffold. The ramifications of this structure–activity relationship are discussed in the context of the design of small molecules targeting smoking cessation

    The relationship of academic indicators and professional disposition to teaching skills: A secondary data analysis.

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    This study compared teaching skill evaluations and professional disposition evaluations for candidates accepted and denied admission to an educator preparation program based upon GPA and testing requirements. The study sought to determine the relationship between academic and non-academic indicators and teaching skills. The data revealed academic indicators of GPA and test scores do not relate to teaching skills. A correlation was found between non-academic indicators, professional dispositions, and the teaching skills evaluation score. The results suggest professional dispositions may be a stronger indicator of success for admission to educator preparation programs and future licensure than GPA and test scores

    What an Agile Leader Does: The Group Dynamics Perspective

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    When large industrial organizations change to (or start with) an agile approach to operations, managers and some employees are supposed to be “agile leaders” often without being given a clear definition of what that comprises when building agile teams. An inductive thematic analysis was used to investigate what 15 appointed leaders actually do and perceive as challenges regarding group dynamics working with an agile approach. Team maturity, Team design, and Culture and mindset were all categories of challenges related to group dynamics that the practitioners face and manage in their work-life that are not explicitly mentioned in the more process-focused agile transformation frameworks. The results suggest that leader mitigation of these three aspects of group dynamics is essential to the success of an agile transformation

    Structural differences determine the relative selectivity of nicotinic compounds for native α4β2^*-, α6β2^*-, α3β4^*- and α7-nicotine acetylcholine receptors

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    Mammalian brain expresses multiple nicotinic acetylcholine receptor (nAChR) subtypes that differ in subunit composition, sites of expression and pharmacological and functional properties. Among known subtypes of receptors, α4β2^* and α6β2^*-nAChR have the highest affinity for nicotine (where ^* indicates possibility of other subunits). The α4β2^*-nAChRs are widely distributed, while α6β2^*-nAChR are restricted to a few regions. Both subtypes modulate release of dopamine from the dopaminergic neurons of the mesoaccumbens pathway thought to be essential for reward and addiction. α4β2^*-nAChR also modulate GABA release in these areas. Identification of selective compounds would facilitate study of nAChR subtypes. An improved understanding of the role of nAChR subtypes may help in developing more effective smoking cessation aids with fewer side effects than current therapeutics.We have screened a series of nicotinic compounds that vary in the distance between the pyridine and the cationic center, in steric bulk, and in flexibility of the molecule. These compoundswere screened usingmembrane binding and synaptosomal function assays, or recordings from GH4C1 cells expressing hα7, to determine affinity, potency and efficacy at four subtypes of nAChRs found in brain, α4β2^*, α6β2^*, α7 and α3β4^*. In addition, physiological assays in gain-of-function mutant mice were used to assess in vivo activity at α4b2^* and α6β2^*-nAChRs. This approach has identified several compounds with agonist or partial agonist activity that display improved selectivity for α6β2^*-nAChR

    THE ROLE OF INTERDEPENDENCE IN THE MICRO-FOUNDATIONS OF ORGANIZATION DESIGN: TASK, GOAL, AND KNOWLEDGE INTERDEPENDENCE

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    Interdependence is a core concept in organization design, yet one that has remained consistently understudied. Current notions of interdependence remain rooted in seminal works, produced at a time when managers’ near-perfect understanding of the task at hand drove the organization design process. In this context, task interdependence was rightly assumed to be exogenously determined by characteristics of the work and the technology. We no longer live in that world, yet our view of interdependence has remained exceedingly task-centric and our treatment of interdependence overly deterministic. As organizations face increasingly unpredictable workstreams and workers co-design the organization alongside managers, our field requires a more comprehensive toolbox that incorporates aspects of agent-based interdependence. In this paper, we synthesize research in organization design, organizational behavior, and other related literatures to examine three types of interdependence that characterize organizations’ workflows: task, goal, and knowledge interdependence. We offer clear definitions for each construct, analyze how each arises endogenously in the design process, explore their interrelations, and pose questions to guide future research

    α6* Nicotinic Acetylcholine Receptor Expression and Function in a Visual Salience Circuit

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    Nicotinic acetylcholine receptors (nAChRs) containing α6 subunits are expressed in only a few brain areas, including midbrain dopamine (DA) neurons, noradrenergic neurons of the locus ceruleus, and retinal ganglion cells. To better understand the regional and subcellular expression pattern of α6-containing nAChRs, we created and studied transgenic mice expressing a variant α6 subunit with green fluorescent protein (GFP) fused in-frame in the M3-M4 intracellular loop. In α6-GFP transgenic mice, α6-dependent synaptosomal DA release and radioligand binding experiments confirmed correct expression and function in vivo. In addition to strong α6* nAChR expression in glutamatergic retinal axons, which terminate in superficial superior colliculus (sSC), we also found α6 subunit expression in a subset of GABAergic cell bodies in this brain area. In patch-clamp recordings from sSC neurons in brain slices from mice expressing hypersensitive α6* nAChRs, we confirmed functional, postsynaptic α6* nAChR expression. Further, sSC GABAergic neurons expressing α6* nAChRs exhibit a tonic conductance mediated by standing activation of hypersensitive α6* nAChRs by ACh. α6* nAChRs also appear in a subpopulation of SC neurons in output layers. Finally, selective activation of α6* nAChRs in vivo induced sSC neuronal activation as measured with c-Fos expression. Together, these results demonstrate that α6* nAChRs are uniquely situated to mediate cholinergic modulation of glutamate and GABA release in SC. The SC has emerged as a potential key brain area responsible for transmitting short-latency salience signals to thalamus and midbrain DA neurons, and these results suggest that α6* nAChRs may be important for nicotinic cholinergic sensitization of this pathway
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