Regulation Of Epidermal Proliferation And Differentiation In Psoriasis

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111132/1/jde01861.pd

Enabling the Intellectually Disabled Mind through Architecture

According to the World Health Organization, roughly 10% of the world population live with mental disability or impairment (Fujira, 2005). For the intellectually disabled, finding a purpose and independence as one transitions into yound adulthood can prove troublesome given their unique shortcomings. In 2015, it was estimated 80,000 intellectually disabled adults were held on waiting lists for residential placement in government-funded programs that could take up to 10 years to complete. Autism Speaks approximates that this number will increase by half a million in that same time span (Lutz, 2015). A greater initiative must take place to assist these individuals in finding as sense of stability in an increasingly dynamic global setting. Some built initiatives have come to exist specifically for those with Autism, such as the Autism Treatment Center of San Antonio. However, these interventions often neglect a large subdivision of the mentally-disabled population known as Down Syndrome. This genetic condition occurs in nearly one in 1000 live births, making it one of the most common birth defects (Rodrigues, 2019). The scope of projects with the intellectually-disabled in mind should be expanded to meet their particular needs so that they may reside alongside their autistic counterparts. With this diversification, the lack of independence in the mentally-disabled community of adults can be tackled more efficiently through the lens of the built environment. Through manipulation of the built world an Integrated Community can be established to enable these individuals to live their lives within the context of the working world. The resulting project will exhibit this objective by creating a space where individuals with special needs can become become a part of a subcommunity that is assimilated independently into the general public, rather than seperated. Although, creating such a space for the intellectually impaired presents unique challenges in its own right. Mental disabilities create internal obstacles for each individual that can prevent them from functioning properly in a given setting. The design solution to be presented will allow them to not only address, but overcome, these obstacles. This solution will serve to remediate sensory overload and similar symptoms, while also allowing for incremental exposure to them so that they can better handle their presence in everyday life. This creates a functional paradox requiring careful compositional considerations in order to create a controlled, but flexible, environmental setting. The aforementioned paradox in turn is the driving force behind the resulting architectural work. This controlled environment will be attained through the implementation of architectural tools and techniques, such as light manipulation, acoustic control, materiality, spatial sequencing, and overall understanding of form and space

Consensus conference on cyclosporin A microemulsion for psoriasis, June 1996

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75561/1/j.1365-2133.1996.d01-1061.x.pd

Molecular mechanisms of retinoid actions in skin

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154473/1/fsb2010009001.pd

A Study of Snippet Length and Informativeness: Behaviour, Performance and User Experience

The design and presentation of a Search Engine Results Page (SERP) has been subject to much research. With many contemporary aspects of the SERP now under scrutiny, work still remains in investigating more traditional SERP components, such as the result summary. Prior studies have examined a variety of different aspects of result summaries, but in this paper we investigate the influence of result summary length on search behaviour, performance and user experience. To this end, we designed and conducted a within-subjects experiment using the TREC AQUAINT news collection with 53 participants. Using Kullback-Leibler distance as a measure of information gain, we examined result summaries of different lengths and selected four conditions where the change in information gain was the greatest: (i) title only; (ii) title plus one snippet; (iii) title plus two snippets; and (iv) title plus four snippets. Findings show that participants broadly preferred longer result summaries, as they were perceived to be more informative. However, their performance in terms of correctly identifying relevant documents was similar across all four conditions. Furthermore, while the participants felt that longer summaries were more informative, empirical observations suggest otherwise; while participants were more likely to click on relevant items given longer summaries, they also were more likely to click on non-relevant items. This shows that longer is not necessarily better, though participants perceived that to be the case - and second, they reveal a positive relationship between the length and informativeness of summaries and their attractiveness (i.e. clickthrough rates). These findings show that there are tensions between perception and performance when designing result summaries that need to be taken into account

Transfer Learning for Multi-language Twitter Election Classification

Both politicians and citizens are increasingly embracing social media as a means to disseminate information and comment on various topics, particularly during significant political events, such as elections. Such commentary during elections is also of interest to social scientists and pollsters. To facilitate the study of social media during elections, there is a need to automatically identify posts that are topically related to those elections. However, current studies have focused on elections within English-speaking regions, and hence the resultant election content classifiers are only applicable for elections in countries where the predominant language is English. On the other hand, as social media is becoming more prevalent worldwide, there is an increasing need for election classifiers that can be generalised across different languages, without building a training dataset for each election. In this paper, based upon transfer learning, we study the development of effective and reusable election classifiers for use on social media across multiple languages. We combine transfer learning with different classifiers such as Support Vector Machines (SVM) and state-of-the-art Convolutional Neural Networks (CNN), which make use of word embedding representations for each social media post. We generalise the learned classifier models for cross-language classification by using a linear translation approach to map the word embedding vectors from one language into another. Experiments conducted over two election datasets in different languages show that without using any training data from the target language, linear translations outperform a classical transfer learning approach, namely Transfer Component Analysis (TCA), by 80% in recall and 25% in F1 measure

Structural basis for membrane insertion by the human ER membrane protein complex

A defining step in the biogenesis of a membrane protein is the insertion of its hydrophobic transmembrane helices into the lipid bilayer. The nine-subunit endoplasmic reticulum (ER) membrane protein complex (EMC) is a conserved co- and posttranslational insertase at the ER. We determined the structure of the human EMC in a lipid nanodisc to an overall resolution of 3.4 angstroms by cryo–electron microscopy, permitting building of a nearly complete atomic model. We used structure-guided mutagenesis to demonstrate that substrate insertion requires a methionine-rich cytosolic loop and occurs via an enclosed hydrophilic vestibule within the membrane formed by the subunits EMC3 and EMC6. We propose that the EMC uses local membrane thinning and a positively charged patch to decrease the energetic barrier for insertion into the bilayer

THE EPIDERMIS AND CYCLIC AMP

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73687/1/j.1365-2133.1974.tb06390.x.pd