91 research outputs found

    Assessment of Synaptic Function During Short-Term Facilitation in Motor Nerve Terminals in the Crayfish

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    An enhanced buildup of [Ca2+]i occurs during short-term facilitation (STF) at the crayfish neuromuscular junction (NMJ). As a model system, this NMJ allows discrete postsynaptic quantal events to be counted and characterized in relation to STF. Providing 10 pulses, at 20 and 40Hz, we monitored postsynaptic quantal events over a discrete region of a nerve terminal with a focal macropatch electrode. Characteristics of quantal events were clustered into groups by peak amplitude and time to the peak amplitude. Since the synapses at this NMJ have varied spacing of active zones, number of active zones and synaptic size, the graded nature of synaptic recruitment is likely one means of titrating synaptic efficacy for the graded depolarization on the non-spiking muscle fiber. Synapses in this preparation would appear to have a quantal signature that can be used for quantifying their activity which is useful in estimating the overall number of active sites. We use mixture modeling to estimate n (number of active sites) and p (probability of vesicle fusion) from the quantal characteristics. In a preparation that was stimulated at 40Hz, synapses were recruited (increase in n) and the number active synapses increased in p. In a different preparation, p increased as the stimulation was changed from 20 to 40Hz, but n did not show a substantial increase; however, during the STF train, p increases slightly. This study provides a novel approach in determining subsets of the single evoked quanta to better estimate n and p which describe synaptic function

    Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol: statistical analysis plan for a prospective, multicenter, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial.

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    BACKGROUND: Observational research suggests that combined therapy with Vitamin C, thiamine and hydrocortisone may reduce mortality in patients with septic shock. METHODS AND DESIGN: The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) trial is a multicenter, double-blind, adaptive sample size, randomized, placebo-controlled trial designed to test the efficacy of combination therapy with vitamin C (1.5 g), thiamine (100 mg), and hydrocortisone (50 mg) given every 6 h for up to 16 doses in patients with respiratory or circulatory dysfunction (or both) resulting from sepsis. The primary outcome is ventilator- and vasopressor-free days with mortality as the key secondary outcome. Recruitment began in August 2018 and is ongoing; 501 participants have been enrolled to date, with a planned maximum sample size of 2000. The Data and Safety Monitoring Board reviewed interim results at N = 200, 300, 400 and 500, and has recommended continuing recruitment. The next interim analysis will occur when N = 1000. This update presents the statistical analysis plan. Specifically, we provide definitions for key treatment and outcome variables, and for intent-to-treat, per-protocol, and safety analysis datasets. We describe the planned descriptive analyses, the main analysis of the primary end point, our approach to secondary and exploratory analyses, and handling of missing data. Our goal is to provide enough detail that our approach could be replicated by an independent study group, thereby enhancing the transparency of the study. TRIAL REGISTRATION: ClinicalTrials.gov, NCT03509350. Registered on 26 April 2018

    Large-Scale Absence of Sharks on Reefs in the Greater-Caribbean: A Footprint of Human Pressures

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    BACKGROUND: In recent decades, large pelagic and coastal shark populations have declined dramatically with increased fishing; however, the status of sharks in other systems such as coral reefs remains largely unassessed despite a long history of exploitation. Here we explore the contemporary distribution and sighting frequency of sharks on reefs in the greater-Caribbean and assess the possible role of human pressures on observed patterns. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed 76,340 underwater surveys carried out by trained volunteer divers between 1993 and 2008. Surveys were grouped within one km2 cells, which allowed us to determine the contemporary geographical distribution and sighting frequency of sharks. Sighting frequency was calculated as the ratio of surveys with sharks to the total number of surveys in each cell. We compared sighting frequency to the number of people in the cell vicinity and used population viability analyses to assess the effects of exploitation on population trends. Sharks, with the exception of nurse sharks occurred mainly in areas with very low human population or strong fishing regulations and marine conservation. Population viability analysis suggests that exploitation alone could explain the large-scale absence; however, this pattern is likely to be exacerbated by additional anthropogenic stressors, such as pollution and habitat degradation, that also correlate with human population. CONCLUSIONS/SIGNIFICANCE: Human pressures in coastal zones have lead to the broad-scale absence of sharks on reefs in the greater-Caribbean. Preventing further loss of sharks requires urgent management measures to curb fishing mortality and to mitigate other anthropogenic stressors to protect sites where sharks still exist. The fact that sharks still occur in some densely populated areas where strong fishing regulations are in place indicates the possibility of success and encourages the implementation of conservation measures

    ΠœΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½Ρ‹ΠΉ ΠΌΡƒΠ·Ρ‹ΠΊΠ°Π»ΡŒΠ½Ρ‹ΠΉ конкурс Π² Ρ„ΠΎΡ€ΠΌΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠΈ ΠΈΠΌΠΈΠ΄ΠΆΠ° страны провСдСния (Π½Π° ΠΏΡ€ΠΈΠΌΠ΅Ρ€Π΅ ЕвровидСния 2017)

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    Аннотация выпускной ΠΊΠ²Π°Π»ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΎΠ½Π½ΠΎΠΉ Ρ€Π°Π±ΠΎΡ‚Ρ‹ ΠžΡ€Π»ΠΎΠ² Никита Π‘Π΅Ρ€Π³Π΅Π΅Π²ΠΈΡ‡ Β«ΠœΠ•Π–Π”Π£ΠΠΠ ΠžΠ”ΠΠ«Π™ ΠœΠ£Π—Π«ΠšΠΠ›Π¬ΠΠ«Π™ КОНКУРБ Π’ Π€ΠžΠ ΠœΠ˜Π ΠžΠ’ΠΠΠ˜Π˜ Π˜ΠœΠ˜Π”Π–Π БВРАНЫ ΠŸΠ ΠžΠ’Π•Π”Π•ΠΠ˜Π― (НА ΠŸΠ Π˜ΠœΠ•Π Π• Π•Π’Π ΠžΠ’Π˜Π”Π•ΠΠ˜Π―-2017)Β» Н. Ρ€ΡƒΠΊ. - Π‘Ρ‹ΠΊΠΎΠ²Π° Π•Π»Π΅Π½Π° Π’Π»Π°Π΄ΠΈΠΌΠΈΡ€ΠΎΠ²Π½Π°, Π΄ΠΎΠΊΡ‚ΠΎΡ€ филологичСских Π½Π°ΡƒΠΊ, Π΄ΠΎΡ†Π΅Π½Ρ‚ ΠšΠ°Ρ„Π΅Π΄Ρ€Π° связСй с ΠΎΠ±Ρ‰Π΅ΡΡ‚Π²Π΅Π½Π½ΠΎΡΡ‚ΡŒΡŽ ΠžΡ‡Π½Π°Ρ Ρ„ΠΎΡ€ΠΌΠ° обучСния ΠΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ: ΠΌΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½Ρ‹ΠΉ ΠΌΡƒΠ·Ρ‹ΠΊΠ°Π»ΡŒΠ½Ρ‹ΠΉ конкурс Π•Π²Ρ€ΠΎΠ²ΠΈΠ΄Π΅Π½ΠΈΠ΅ ΠΊΠ°ΠΊ самоС ΠΌΠ°ΡΡˆΡ‚Π°Π±Π½ΠΎΠ΅ рСгулярноС высокотСхнологичноС Ρ‚Π΅Π»Π΅Π²ΠΈΠ·ΠΈΠΎΠ½Π½ΠΎΠ΅ ΠΈ ΠΌΠ΅Π΄ΠΈΠ°-событиС, ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠ΅ . Π• Π΅ΠΆΠ΅Π³ΠΎΠ΄Π½ΠΎ Π°ΠΊΡ†Π΅Π½Ρ‚ΠΈΡ€ΡƒΠ΅Ρ‚ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ Π°ΡƒΠ΄ΠΈΡ‚ΠΎΡ€ΠΈΠΈ Π½Π° Π½Π°Ρ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎ-ΠΊΡƒΠ»ΡŒΡ‚ΡƒΡ€Π½Ρ‹Ρ… особСнностях страны-ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ‚ΠΎΡ€Π° конкурса, Ρ„ΠΎΡ€ΠΌΠΈΡ€ΡƒΠ΅Ρ‚ Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Π΅ туристичСскиС ΠΏΠΎΡ‚ΠΎΠΊΠΈ ΠΈ Ρ‚Π΅ΠΌ самым способствуСт Ρ„ΠΎΡ€ΠΌΠΈΡ€ΠΎΠ²Π°Π½ΠΈΡŽ ΠΈΠΌΠΈΠ΄ΠΆΠ° Ρ‚Π΅Ρ€Ρ€ΠΈΡ‚ΠΎΡ€ΠΈΠΈ. Π‘ΠΎΠ»Π΅Π΅ Ρ‚ΠΎΠ³ΠΎ, ΠΏΠΎΠ±Π΅Π΄Π° страны-участницы конкурса ЕвровидСния Π·Π°Ρ‡Π°ΡΡ‚ΡƒΡŽ ΠΎΡ‚Ρ€Π°ΠΆΠ°Π΅Ρ‚ ΠΈΠ΄Π΅ΠΎΠ»ΠΎΠ³ΠΎ-политичСский Π²Π΅ΠΊΡ‚ΠΎΡ€ Π•Π²Ρ€ΠΎΠΏΡ‹ ΠΈ ΠΏΠΎ сути Π΄Π΅Π»Π° выполняСт Ρ„ΡƒΠ½ΠΊΡ†ΠΈΡŽ политичСского PR страны-побСдитСля ΠΈ страны-хозяйки мСроприятия. Π‘Π»Π΅Π΄ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎ Π°Π½Π°Π»ΠΈΠ· ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΡƒΠ΅ΠΌΡ‹Ρ… Π½Π° мСроприятии ΠΊΠΎΠΌΠΌΡƒΠ½ΠΈΠΊΠ°Ρ‚ΠΈΠ²Π½Ρ‹Ρ… Ρ‚Π΅Ρ…Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ являСтся Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹ΠΌ ΠΈ вострСбованным для событийного ΠΈ ΡƒΡΡ‚Ρ€ΠΎΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠ³ΠΎ PR ΠžΠ±ΡŠΠ΅ΠΊΡ‚ исслСдования: ΠΊΠΎΠΌΠΌΡƒΠ½ΠΈΠΊΠ°Ρ†ΠΈΠΎΠ½Π½Ρ‹Π΅ активности ΠΌΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΌΡƒΠ·Ρ‹ΠΊΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ конкурса (Π½Π° ΠΏΡ€ΠΈΠΌΠ΅Ρ€Π΅ ЕвровидСния Π² КиСвС Π² 2017 Π³.). ΠŸΡ€Π΅Π΄ΠΌΠ΅Ρ‚ исслСдования: функция статусного PR-мСроприятия Π² Ρ„ΠΎΡ€ΠΌΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠΈ ΠΈΠΌΠΈΠ΄ΠΆΠ° страны. ЦСль исслСдования: Π΄ΠΎΠΊΠ°Π·Π°Ρ‚ΡŒ, Ρ‡Ρ‚ΠΎ ΠΌΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½Ρ‹ΠΉ ΠΌΡƒΠ·Ρ‹ΠΊΠ°Π»ΡŒΠ½Ρ‹ΠΉ конкурс Π•Π²Ρ€ΠΎΠ²ΠΈΠ΄Π΅Π½ΠΈΠ΅ способствуСт Ρ„ΠΎΡ€ΠΌΠΈΡ€ΠΎΠ²Π°Π½ΠΈΡŽ ΠΈΠΌΠΈΠ΄ΠΆΠ° страны провСдСния. Π—Π°Π΄Π°Ρ‡ΠΈ исслСдования: Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Ρ‚ΡŒ тСрминологичСский Π°ΠΏΠΏΠ°Ρ€Π°Ρ‚ исслСдования Π½Π° основС Π½Π°ΡƒΡ‡Π½ΠΎΠΉ Π»ΠΈΡ‚Π΅Ρ€Π°Ρ‚ΡƒΡ€Ρ‹ ΠΏΠΎ ΠΈΠΌΠΈΠ΄ΠΆΠΌΠ΅ΠΉΠΊΠΈΠ½Π³Ρƒ, Π±Ρ€Π΅Π½Π΄ΠΈΠ½Π³Ρƒ ΠΈ ΠΈΠ²Π΅Π½Ρ‚-ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½Ρ‚Ρƒ; ΠΎΠΏΡ€Π΅Π΄Π΅Π»ΠΈΡ‚ΡŒ Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹Π΅ ΠΊΠΎΠΌΠΌΡƒΠ½ΠΈΠΊΠ°Ρ†ΠΈΠΎΠ½Π½Ρ‹Π΅ Ρ‚Π΅Ρ…Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ, примСняСмыС Π² Ρ€Π°ΠΌΠΊΠ°Ρ… ΡΠΏΠ΅Ρ†ΠΈΠ°Π»ΡŒΠ½Ρ‹Ρ… событий для формирования ΠΈΠΌΠΈΠ΄ΠΆΠ° страны; ΠΎΠΏΠΈΡΠ°Ρ‚ΡŒ Ρ€ΠΎΠ»ΡŒ ЕвропСйского Π’Π΅Ρ‰Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠ³ΠΎ Боюза ΠΊΠ°ΠΊ ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ‚ΠΎΡ€Π° ЕвровидСния Π² Ρ„ΠΎΡ€ΠΌΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠΈ ΠΈΠΌΠΈΠ΄ΠΆΠ° страны провСдСния конкурса; ΠΎΡ†Π΅Π½ΠΈΡ‚ΡŒ ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ Ρ€Π΅Π°Π»ΠΈΠ·ΠΎΠ²Π°Π½Π½Ρ‹Ρ… ΠΊΠΎΠΌΠΌΡƒΠ½ΠΈΠΊΠ°Ρ‚ΠΈΠ²Π½Ρ‹Ρ… Ρ‚Π΅Ρ…Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ формирования ΠΈΠΌΠΈΠ΄ΠΆΠ° страны Π² Ρ€Π°ΠΌΠΊΠ°Ρ… ЕвровидСния; Π΄Π°Ρ‚ΡŒ Ρ€Π΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°Ρ†ΠΈΠΈ ΠΏΠΎ Ρ„ΠΎΡ€ΠΌΠΈΡ€ΠΎΠ²Π°Π½ΠΈΡŽ ΠΈΠΌΠΈΠ΄ΠΆΠ° страны с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ ЕвровидСния. ВСорСтичСская Π±Π°Π·Π°: Π½Π°ΡƒΡ‡Π½Ρ‹Π΅ Ρ‚Ρ€ΡƒΠ΄Ρ‹ Π•. Π‘Ρ‹ΠΊΠΎΠ²ΠΎΠΉ, Π”. Π“Π°Π²Ρ€Ρ‹, А. ΠŸΠ°Π½ΠΊΡ€ΡƒΡ…ΠΈΠ½Π°, Π‘. ДТСнСса, Π•. ΠšΠ°Π²Π΅Ρ€ΠΈΠ½ΠΎΠΉ, Π£. Π₯Π°Π»ΡŒΡ†Π±Π°ΡƒΡ€Π°, Π”ΠΆ. Π“ΠΎΠ»Π΄Π±Π»Π°Ρ‚Ρ‚Π° Π° Ρ‚Π°ΠΊΠΆΠ΅ Ρ‚Ρ€ΡƒΠ΄Ρ‹ Π”. Пассмана ΠΎ ΠΌΡƒΠ·Ρ‹ΠΊΠ°Π»ΡŒΠ½ΠΎΠΌ бизнСсС, П. Π”ΠΆΠΎΡ€Π΄Π°Π½Π° ΠΎ ΠΏΡ€ΠΎΠ΄Π²ΠΈΠΆΠ΅Π½ΠΈΠΈ ΠΈΠΌΠΈΠ΄ΠΆΠ° стран с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ ЕвровидСния ΠΈ Π΄Ρ€. ЭмпиричСская Π±Π°Π·Π°: PR-Π΄ΠΎΠΊΡƒΠΌΠ΅Π½Ρ‚Ρ‹, Ρ€Π°Π·ΠΌΠ΅Ρ‰Π΅Π½Π½Ρ‹Π΅ Π½Π° сайтС ЕвровидСния ΠΈ ЕвропСйского Π’Π΅Ρ‰Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠ³ΠΎ Боюза; Π±ΠΎΠ»Π΅Π΅ ΠΏΠΎΠ»ΡƒΡ‚ΠΎΡ€Π° ΠΌΠΈΠ»Π»ΠΈΠΎΠ½Π° статСй ΠΎΠ± Π£ΠΊΡ€Π°ΠΈΠ½Π΅ Π² СвропСйских БМИ, Ρ€Π°Π·ΠΌΠ΅Ρ‰Π΅Π½Π½Ρ‹Π΅ Π² Π±Π°Π·Π΅ ΠΏΡ€ΠΎΠ΅ΠΊΡ‚Π° ΠΌΠΎΠ½ΠΈΡ‚ΠΎΡ€ΠΈΠ½Π³Π° ΠΌΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΈΠΌΠΈΠ΄ΠΆΠ° Π£ΠΊΡ€Π°ΠΈΠ½Ρ‹ Β«OkoΒ»; Π΄Π°Π½Π½Ρ‹Π΅ Π±Π°Π·Ρ‹ ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»ΠΎΠ² БМИ ΠΈ ΡΠΎΡ†ΠΈΠ°Π»ΡŒΠ½Ρ‹Ρ… ΠΌΠ΅Π΄ΠΈΠ° Factiva; Π΄Π°Π½Π½Ρ‹Π΅ Google.Analytics. ΠŸΡ€Π°ΠΊΡ‚ΠΈΡ‡Π΅ΡΠΊΠ°Ρ Π·Π½Π°Ρ‡ΠΈΠΌΠΎΡΡ‚ΡŒ: исслСдованиС Π΄ΠΎΠΊΠ°Π·Ρ‹Π²Π°Π΅Ρ‚, Ρ‡Ρ‚ΠΎ ΠΌΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½Ρ‹ΠΉ ΠΌΡƒΠ·Ρ‹ΠΊΠ°Π»ΡŒΠ½Ρ‹ΠΉ конкурс Π•Π²Ρ€ΠΎΠ²ΠΈΠ΄Π΅Π½ΠΈΠ΅ Ρ„ΠΎΡ€ΠΌΠΈΡ€ΡƒΠ΅Ρ‚ ΠΈΠΌΠΈΠ΄ΠΆ страны провСдСния нСзависимо ΠΎΡ‚ ΡƒΡΠΏΠ΅ΡˆΠ½ΠΎΡΡ‚ΠΈ использования ΠΊΠΎΠ½ΠΊΡ€Π΅Ρ‚Π½Ρ‹Ρ… Ρ‚Π΅Ρ…Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ формирования ΠΈΠΌΠΈΠ΄ΠΆΠ° страны. ВСзисы исслСдования Π±Ρ‹Π»ΠΈ Π°ΠΏΡ€ΠΎΠ±ΠΈΡ€ΠΎΠ²Π°Π½Ρ‹ Π½Π° ΠΌΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½ΠΎΠΌ Π½Π°ΡƒΡ‡Π½ΠΎΠΌ Ρ„ΠΎΡ€ΡƒΠΌΠ΅ «МСдиа Π² соврСмСнном ΠΌΠΈΡ€Π΅. 57-Π΅ ΠŸΠ΅Ρ‚Π΅Ρ€Π±ΡƒΡ€Π³ΡΠΊΠΈΠ΅ чтСния», ΠΎΠΏΡƒΠ±Π»ΠΈΠΊΠΎΠ²Π°Π½Ρ‹ Π² сборникС ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»ΠΎΠ² статСй Ρ„ΠΎΡ€ΡƒΠΌΠ° ΠΈ ΠΈΠΌΠ΅ΡŽΡ‚ статус Π½Π°ΡƒΡ‡Π½ΠΎΠΉ ΡΡ‚Π°Ρ‚ΡŒΠΈ, Ρ€Π°Π·ΠΌΠ΅Ρ‰Π΅Π½Π½ΠΎΠΉ Π² Π±Π°Π·Π΅ РИНЦ. Π‘Ρ‚Ρ€ΡƒΠΊΡ‚ΡƒΡ€Π° Ρ€Π°Π±ΠΎΡ‚Ρ‹: Π Π°Π±ΠΎΡ‚Π° состоит ΠΈΠ· ввСдСния, 3 Π³Π»Π°Π²: «функция ΡΠΏΠ΅Ρ†ΠΈΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ события Π² Ρ„ΠΎΡ€ΠΌΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠΈ ΠΈΠΌΠΈΠ΄ΠΆΠ° страны», Β«Π•Π²Ρ€ΠΎΠ²ΠΈΠ΄Π΅Π½ΠΈΠ΅ ΠΊΠ°ΠΊ ΡΠΏΠ΅Ρ†ΠΈΠ°Π»ΡŒΠ½ΠΎΠ΅ событиС ЕвропСйского Π’Π΅Ρ‰Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠ³ΠΎ Боюза» ΠΈ Β«ΠΊΠΎΠΌΠΌΡƒΠ½ΠΈΠΊΠ°Ρ†ΠΈΠΎΠ½Π½Ρ‹ΠΉ ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π» ЕвровидСния ΠΊΠ°ΠΊ ΠΏΠ»ΠΎΡ‰Π°Π΄ΠΊΠΈ для формирования ΠΈΠΌΠΈΠ΄ΠΆΠ° страны», Π·Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΡ, списка использованной Π»ΠΈΡ‚Π΅Ρ€Π°Ρ‚ΡƒΡ€Ρ‹ ΠΈΠ· 67 ΠΏΠΎΠ·ΠΈΡ†ΠΈΠΉ ΠΈ 12 ΠΏΡ€ΠΈΠ»ΠΎΠΆΠ΅Π½ΠΈΠΉ. ΠžΠ±Ρ‰ΠΈΠΉ объСм 76 страниц.Abstract of graduating qualification thesis Mikita Arlou INTERNATIONAL MUSIC CONTEST IN HOST COUNTRY IMAGE FORMATION (ON THE EXAMPLE OF EUROVISION 2017) Supervisor associate professor Elena Bykova, doctor of philology Department of PR in business full-time study Relevance: the international music contest Eurovision as the most wide scale regular high tech TV and Media event which annually emphasizes audience attention on national cultural features of the host country, forms tourist flows which have huge influence on territorial image formation. Besides the win of a participating in the Eurovision country often shows the ideological and political European vector and in fact serves as political PR of the winning or host country. Consequently the analysis of applied communication technologies is relevant and in-demand for event PR. Research object: communication activities of international music contest (on the example of Eurovision in Kyiv in 2017). Research subject: function of status PR event in country image formation. The aim of research: to prove that international music contest Eurovision contributes host country image formation. The tasks of research: to develop research terminology based on scientific literature on image making, branding and event management; to define actual communication technologies applied in special PR events on country image formation; to describe European Broadcasting Union role in host country image formation; to appreciate effectiveness of applied communication technologies on host country image formation in Eurovision; to give recommendations for host country image formation with the help of Eurovision. Theoretical base: scientific works written by E. Bykova, D. Gavra, A. Pankrukhin, B. Jenes, E. Kaverina, U. Halcbaur, J. Goldblatt and D. PassmanΒ΄s works on music business and P. Jordan on county image building with the help of Eurovision, etc. The empirical base: PR documents from official Eurovision and European Broadcasting Union websites; more than 1.5 million articles on Ukraine in European media stored in the base of international Ukrainian image monitoring project Oko; content of the mass media and social media base Factiva; Google.Analytics data. Practical significance: the research proves that international music contest Eurovision is relevant for the host country image formation independently of the success level of applied country image formation communication technologies. Approbation: General positions of current thesis were aprobated on international scientific forum Media in modern world and were published at the collection of articles of the forum and have the status of a scientific article posted in the RINC database. Thesis structure: Research consists of introduction, 3 chapters: Special event function in country image formation, Eurovision as EBU special event and communication potential of Eurovision as a platform for image formation; conclusion, literature list from 67 positions and 12 attachments. The total volume is 76 pages

    REVIEWS: CURRENT TOPICS Statistics and bioinformatics in nutritional sciences: analysis of complex data in the era of systems biologyβ˜†

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    Abstract Over the past 2 decades, there have been revolutionary developments in life science technologies characterized by high throughput, high efficiency, and rapid computation. Nutritionists now have the advanced methodologies for the analysis of DNA, RNA, protein, low-molecular-weight metabolites, as well as access to bioinformatics databases. Statistics, which can be defined as the process of making scientific inferences from data that contain variability, has historically played an integral role in advancing nutritional sciences. Currently, in the era of systems biology, statistics has become an increasingly important tool to quantitatively analyze information about biological macromolecules. This article describes general terms used in statistical analysis of large, complex experimental data. These terms include experimental design, power analysis, sample size calculation, and experimental errors (Type I and II errors) for nutritional studies at population, tissue, cellular, and molecular levels. In addition, we highlighted various sources of experimental variations in studies involving microarray gene expression, real-time polymerase chain reaction, proteomics, and other bioinformatics technologies. Moreover, we provided guidelines for nutritionists and other biomedical scientists to plan and conduct studies and to analyze the complex data. Appropriate statistical analyses are expected to make an important contribution to solving major nutrition-associated problems in humans and animals (including obesity, diabetes, cardiovascular disease, cancer, ageing, and intrauterine growth retardation)
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