Field Validity and Feasibility of Four Techniques for the Detection of Trichuris in Simians: A Model for Monitoring Drug Efficacy in Public Health?

Worldwide, millions of people are infected with soil-transmitted helminths, particularly in developing countries. Efforts to control these infections involve periodic mass drug treatment in endemic areas. Since these large-scale interventions are likely to intensify, monitoring of drug efficacy has become a key issue in order to detect the emergence of resistance. At present, the drop in infection intensity is under examination for monitoring the drug efficacy. However, studies comparing detection techniques based on infection intensities are scarce. Moreover, little attention has been addressed to their feasibility and their ability to estimate drug efficacies. We have compared different techniques for the detection of whipworm (Trichuris) in simian stool samples based on prevalence, infection intensities, feasibility and ability to estimate the ‘true’ drug efficacy. We have found that techniques often fail to detect low infection intensities and that not all techniques are appropriate for estimating infection intensities. The time needed to obtain a test result varied from 3.9 to 17.7 min/sample. Finally, accurate estimates of drug efficacy were only obtained in high pre-drug administration infection intensities. To conclude, along with accurate estimates of infection intensities, feasibility is a considerable criterion for the detection techniques used in drug efficacy monitoring programs

Le Service d'Archéologie et des Monuments Historiques de la Ville de Gand

Vandenhoute J. Le Service d'Archéologie et des Monuments Historiques de la Ville de Gand. In: Revue du Nord, tome 60, n°239, Octobre-décembre 1978. pp. 908-909

Le Service d'Archéologie et des Monuments Historiques de la Ville de Gand

Vandenhoute J. Le Service d'Archéologie et des Monuments Historiques de la Ville de Gand. In: Revue du Nord, tome 60, n°239, Octobre-décembre 1978. pp. 908-909

Colloque d'archéologie médiévale belge (Gand 1978)

Vandenhoute J. Colloque d'archéologie médiévale belge (Gand 1978) . In: Revue du Nord, tome 60, n°239, Octobre-décembre 1978. pp. 904-908

Colloque d'archéologie médiévale belge (Gand 1978)

Vandenhoute J. Colloque d'archéologie médiévale belge (Gand 1978) . In: Revue du Nord, tome 60, n°239, Octobre-décembre 1978. pp. 904-908

Journée "Viking" à Gand

Laleman M.C., Vandenhoute J. Journée "Viking" à Gand. In: Revue du Nord, tome 62, n°247, Octobre-décembre 1980. pp. 930-932

Does three-dimensional power Doppler ultrasound predict histopathological findings of uterine fibroids? A preliminary study.

To compare three-dimensional (3D) power Doppler sonographic characteristics of fibroids with histopathological parameters.SCOPUS: ar.jFLWINinfo:eu-repo/semantics/publishe