The relationship between HIV seroconversion illness, HIV test interval and time to AIDS in a seroconverter cohort.

Seroconversion illness is known to be associated with more rapid HIV disease progression. However, symptoms are often subjective and prone to recall bias. We describe symptoms reported as seroconversion illness and examine the relationship between illness, HIV test interval (time between antibody-negative and anibody-positive test dates) and the effect of both on time to AIDS from seroconversion. We used a Cox model, adjusting for age, sex, exposure group and year of estimated seroconversion. Of 1820 individuals, information on seroconversion illness was available for 1244 of whom 423 (34%) reported symptomatic seroconversion. Persons with a short test interval (< or = 2 months) were significantly more likely to report an illness than people with a longer interval (OR 6.76, 95% CI 4.75-9.62). Time to AIDS was significantly faster (P = 0.01) in those with a short test interval. The HIV test interval is a useful replacement for information on seroconversion illness in studies of HIV disease progression

Good night, sleep tight (remix)

Good Night, Sleep Tight is an interactive virtual reality performance created by theatre and digital arts company ZU-UK. It was previewed at Gerry’s Kitchen in July 2017. Combining VR and binaural technologies, participants are put to bed and transported to a dreamscape composed of childhood imagery and aerial cityscapes. This artistic position remixes the audience’s experience and the artistic processes of Good Night, Sleep Tight to proffer a critical engagement with the aesthetics of VR. Theories pertaining to VR and theatre are emerging but not yet fully established. The discourse between technologists and artists is key to understanding how VR is a new artistic medium requiring a language not solely redolent of gaming or theatre. The format of this article reflects ZU-UK’s contention that VR experiences are best designed as collaborations between artists and audiences who construct an imaginary world through interactive media. The seven scenes below concentrate on different aspects of the rehearsal process and the final performance from the perspectives of the ZU-UK directors, VR technologists, and participants. Interspersed throughout the article are fragments from the Good Night, Sleep Tight script and a description of the piece from the reader’s perspective, who acts as ZU-UK’s imaginary audience member

Distinguished non-Archimedean representations

For a symmetric space (G,H), one is interested in understanding the vector space of H-invariant linear forms on a representation \pi of G. In particular an important question is whether or not the dimension of this space is bounded by one. We cover the known results for the pair (G=R_{E/F}GL(n),H=GL(n)), and then discuss the corresponding SL(n) case. In this paper, we show that (G=R_{E/F}SL(n),H=SL(n)) is a Gelfand pair when n is odd. When $n$ is even, the space of H-invariant forms on \pi can have dimension more than one even when \pi is supercuspidal. The latter work is joint with Dipendra Prasad

Pregnancy is associated with elevation of liver enzymes in HIV-positive women on antiretroviral therapy.

The objective of this study is to assess whether pregnancy is associated with an increased risk of liver enzyme elevation (LEE) and severe LEE in HIV-positive women on antiretroviral therapy (ART)

Strategies for connecting low income communities to the creative economy through play : two case studies in Northern England

This ground-breaking research defines a new approach for engaging low income and disenfranchised communities in the creative economy. The authors propose that demystifying creativity and reframing it as an adaptive productive process can lead to a flourishing of aspiration and potential among target communities. Through research in a low income community and among disabled people in Northern England, the authors found that focusing on rubrics of exploration, play and 'purposeful meandering' tackled anxieties around creative production and a lack of confidence and self-belief. This emphasis on all people as cultural producers however needs to connect with clearer pathways into the creative industries

A proposed DAQ system for a calorimeter at the International Linear Collider

This note describes R&D to be carried out on the data acquisition system for a calorimeter at the future International Linear Collider. A generic calorimeter and data acquisition system is described. Within this framework modified designs and potential bottlenecks within the current system are described. Solutions leading up to a technical design report will to be carried out within CALICE-UK groups.Comment: 13 pages, 4 figure

The recoverability of fingerprints on paper exposed to elevated temperatures - Part 1: comparison of enhancement techniques

This research investigates the recoverability of fingerprints which have been exposed to elevated temperatures in order to mimic the environment a piece of paper may be exposed to within an arson scene. Arson is an expensive crime, costing the UK economy, on average, £53.8 million each week [1]. Anything which may give rise to the identity of the fire setter should be analysed and as such, unburnt paper may be a potential source of fingerprints. While it is true that even a moderate fire will obscure and render partially useless some types of evidence, many items, including fingerprints, may still survive [2-4]. This research has shown that fingerprints are still retrievable from paper which has been subjected to the maximum testing conditions of 200˚C for 320min. In fact, some fingerprints naturally enhance themselves by the heating process. This investigation has also shown that the most effective enhancement technique was found to be 1,8-diazafluoren-9-one (DFO) for exposure temperatures upto 100˚C. Physical developer (PD) is the most effective enhancement technique for exposure temperatures from 100˚C to 200˚C. For porous surfaces, there are fingerprint development techniques which are effective at enhancing fingerprints exposed upto a temperature of 200˚C, irrespective of the firefighting extinguishing technique, as PD, in addition to developing fingerprints exposed to high temperatures, is one of the few processes which will enhance fingermarks on wetted surfaces

A comparison of six fingerprint enhancement techniques for the recovery of latent fingerprints from unfired cartridge cases

This work compared the effectiveness of six different enhancement methods on six different sizes of brass cartridges. One sebaceous fingerprint was deposited onto twenty-five of each size of cartridge to enable a statistical evaluation of the enhancement methods for each cartridge size to be undertaken. The enhancement methods compared were superglue followed by BY40, superglue followed by gun blue followed by BY40, gun blue only, superglue followed by palladium deposition, palladium deposition only, and powder suspension. The six different cartridges used in this study were .22s, .32s, 9mm, .38s, ribbed shotgun, and smooth shotgun. The study found that more potentially identifiable fingerprints were enhanced on the larger cartridge cases. This was due to the surface area on the smaller cartridges, and in particular the .22s provided little ridge detail. Two techniques provided the best results - superglue followed by gun blue followed by BY40, and superglue followed by palladium deposition. This showed that the combination of the cyanoacrylate fuming and the metal oxidation reactions is increasing the yield of potentially identifiable fingerprints compared with the use of the techniques separately. Both techniques were also found to give reproducible results. These two enhancement techniques were also compared statistically and no statistical difference in their effectiveness was found suggesting both techniques are equally as effective at enhancing fingerprints on brass cartridge cases