Littlestock Brook natural flood management pilot: hydrological and water quality monitoring and analysis report

The Littlestock Brook Natural Flood Management (NFM) trial was a pilot project that ran from 2016 to 2022. Key objectives were to reduce flood risk to Milton-under-Wychwood and enhance the river environment. Through partnership working the Environment Agency collaborated with Wild Oxfordshire, the Evenlode Catchment Partnership, Bruern Estate and the local community to deliver NFM measures. UKCEH has undertaken a detailed monitoring campaign to assess the effectiveness of the measures on reducing flood flows and improving water quality. This report describes the monitoring network, observational methods, equipment adopted, the data processing and analysis undertaken

Evaluating land use and management Natural Flood Management potential

Soil use and management as a form of Natural Flood Management (NFM) has potential to increase infiltration and soil water storage above and below ground. As a result, it can slow the flow of water and reduce flooding caused by surface run-off, rivers and groundwater. Here, we report findings from the LANDWISE project, which examined the potential of land use and management in lowland groundwater-fed catchments in the River Thames Basin, England. We focused on five soil classes within two geology types: shallow permeable soils on carbonate geology (Limestone and Chalk) and deep clay soils on mudstone geology; across agricultural land, grassland and woodland. We compared different farming systems, including conventional, innovative and organic agriculture. We gathered empirical evidence of within and between field variation for different soil use and management strategies, through a broad survey of 164 fields and an in-depth survey of 7 sites. We show that both land use and soil type are significant in affecting bulk density. We also show correlation between organic matter and bulk density, which is important for NFM as organic matter content can be controlled by land use and management practices. We adopted a co-production research approach, to deliver usable impacts for farmers who will ultimately deliver NFM through land use change and management. This work will inform policy and design and delivery of agri-environment schemes; such as the soil survey scheme, a key part of the DEFRA soil action plan. It will help co-deliver NFM alongside other ecosystem services

Uva-ursi extract and ibuprofen as alternative treatments for uncomplicated urinary tract infection in women (ATAFUTI):a factorial randomized trial

Objectives: The aim was to investigate if offering symptomatic therapy (Uva-ursi or ibuprofen) alongside a delayed prescription would relieve symptoms and reduce the consumption of antibiotics for adult women presenting with acute uncomplicated urinary tract infection (UTI). Methods: A 2 × 2 factorial placebo controlled randomized trial in primary care. The participants were 382 women aged 18–70 years with symptoms of dysuria, urgency, or frequency of urination and suspected by a clinician to have a lower UTI. The interventions were Uva-ursi extract and/or ibuprofen advice. All women were provided with a delayed or ‘back-up’ prescription for antibiotics. Missing data were imputed using multiple imputation methods (ISRCTN registry: ISRCTN43397016). Results: An ITT analysis of mean score for frequency symptoms assessed on Days 2–4 found no evidence of a difference between Uva-ursi vs. placebo –0.06 (95% CI –0.33 to 0.21; p 0.661), nor ibuprofen vs. no ibuprofen advice –0.01 (95% CI –0.27 to 0.26; p 0.951). There was no evidence of a reduction in antibiotic consumption with Uva-ursi (39.9% vs. placebo 47.4%; logistic regression odds ratio (OR) 0.59 (95% CI 0.22–1.58; p 0.293) but there was a significant reduction for ibuprofen advice (34.9% vs. no advice 51.0%; OR 0.27 (95% CI 0.10 to 0.72; p 0.009). There were no safety concerns and no episodes of upper tract infection were recorded. Conclusions: We found no evidence of an effect of either intervention on the severity of frequency symptoms. There is evidence that advice to take ibuprofen will reduce antibiotic consumption without increasing complications. For every seven women given this advice, one less will use antibiotics.</p

Trends and outcome of neoadjuvant treatment for rectal cancer: A retrospective analysis and critical assessment of a 10-year prospective national registry on behalf of the Spanish Rectal Cancer Project

Introduction: Preoperative treatment and adequate surgery increase local control in rectal cancer. However, modalities and indications for neoadjuvant treatment may be controversial. Aim of this study was to assess the trends of preoperative treatment and outcomes in patients with rectal cancer included in the Rectal Cancer Registry of the Spanish Associations of Surgeons. Method: This is a STROBE-compliant retrospective analysis of a prospective database. All patients operated on with curative intention included in the Rectal Cancer Registry were included. Analyses were performed to compare the use of neoadjuvant/adjuvant treatment in three timeframes: I)2006–2009; II)2010–2013; III)2014–2017. Survival analyses were run for 3-year survival in timeframes I-II. Results: Out of 14, 391 patients, 8871 (61.6%) received neoadjuvant treatment. Long-course chemo/radiotherapy was the most used approach (79.9%), followed by short-course radiotherapy ± chemotherapy (7.6%). The use of neoadjuvant treatment for cancer of the upper third (15-11 cm) increased over time (31.5%vs 34.5%vs 38.6%, p = 0.0018). The complete regression rate slightly increased over time (15.6% vs 16% vs 18.5%; p = 0.0093); the proportion of patients with involved circumferential resection margins (CRM) went down from 8.2% to 7.3%and 5.5% (p = 0.0004). Neoadjuvant treatment significantly decreased positive CRM in lower third tumors (OR 0.71, 0.59–0.87, Cochrane-Mantel-Haenszel P = 0.0008). Most ypN0 patients also received adjuvant therapy. In MR-defined stage III patients, preoperative treatment was associated with significantly longer local-recurrence-free survival (p < 0.0001), and cancer-specific survival (p < 0.0001). The survival benefit was smaller in upper third cancers. Conclusion: There was an increasing trend and a potential overuse of neoadjuvant treatment in cancer of the upper rectum. Most ypN0 patients received postoperative treatment. Involvement of CRM in lower third tumors was reduced after neoadjuvant treatment. Stage III and MRcN + benefited the most

NMR investigations on the lithiation and delithiation of nanosilicon-based anodes for Li-ion batteries

Lithiation and delithiation of nanosilicon anodes of 100-200 nm diameter have been probed by ex situ solid-state high-resolution 7Li nuclear magnetic resonance (NMR) and transmission electron microscopy (TEM) methods. Samples were charged within pouch cells up to capacities of 1,500 mAh/g at 0.1 C, and subsequently discharged at the same rate. The NMR spectra reveal important quantitative information on the local lithium environments during the various stages of the charging/discharging process. The TEM experiments show that the electrochemical lithiation of nanosilicon particles results in core-shell materials, consisting of Li xSi shells surrounding a core of residual silicon. The NMR spectra yield approximate Li/Si ratios of the lithium silicides present in the shells, based on the distinct local environments of the various types of 7Li nuclei present. The combination of NMR with TEM gives important quantitative conclusions about the nature of the electrochemical lithiation process: Following the initial formation of the solid electrolyte interphase layer, which accounts for an irreversible capacity of 240 mAh/g, lithium silicide environments with intermediate Li concentrations (Li 12Si 7, Li 7Si 3, and Li 13Si 4) are formed at the 500 to 1,000 mAh/g range during the charging process. At a certain penetration depth, further lithiation does not progress any further toward the interior of the silicon particles but rather leads to the formation of increasing amounts of the lithium-richest silicide, Li 15Si 4-type environments. Delithiation does not result in the reappearance of the intermediate-stage phases but rather only changes the amount of Li 15Si 4 present, indicating no microscopic reversibility. Based on these results, a detailed quantitative model of nanophase composition versus penetration depth has been developed. The results indicate the power and potential of solid-state NMR spectroscopy for elucidating the charging/discharging mechanism of nano-Si anodes. © 2010 Springer-Verlag

The assessment of NVQs

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